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公开(公告)号：KR102211261B1
公开(公告)日：2021-02-04
申请号：KR1020157019688
申请日：2013-12-18
Applicant: 로레알
IPC: A61K8/49 , C07D309/10 , A61Q5/08 , A61Q19/02
Abstract: C-자일로사이드화합물, 조성물및 피부의탈색소를위한그의용도. 본발명은하기화학식 (I) 의화합물을포함하는피부탈색소조성물에관한것이다: TIFF112015070104619-pct00076.tif2554 여기에서: - 화학식 (I) 의화합물은자일로스유도체임.
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公开(公告)号：KR101132578B1
公开(公告)日：2012-04-06
申请号：KR1020090022255
申请日：2009-03-16
Applicant: 로레알
CPC classification number: C12N5/0698 , C12N2501/11 , C12N2501/117 , C12N2501/39 , C12N2502/091 , C12N2502/094 , C12N2502/1323 , C12N2533/50 , C12N2533/52 , C12N2533/54 , G01N33/5088
Abstract: In vitro skin equivalent comprises: epidermis equivalent comprising keratinocyte forming at least one basal layer, at least one superficial layer and at least one dermis equivalent; and melanocytes producing constitutive melanin and living fibroblasts, where the entire melanocytes are in the basal layer of the epidermis equivalent. Independent claims are included for: (1) a process for preparing the skin equivalent, comprising (a) contacting fibroblasts and collagen solution and then incubated for a sufficient time to obtain a collagen matrix which are contacted in which the fibroblasts are distributed, constituting a dermis equivalent, (b) seeding the dermis equivalent by a mixture of keratinocytes and melanocytes on dermis equivalent obtained in (a) and culturing by immersing in a liquid medium, and (c) emerging keratinocytes and melanocytes from the culture on the dermis equivalent obtained in (b) and culturing at the air-liquid interface to obtain a multilayered epidermis equivalent containing melanocytes, on dermis equivalent containing fibroblasts in a collagen matrix constituting skin equivalent; and (2) a process for evaluating the ability of an agent to modulate the pigmentation, comprising (a1) applying the agent to the in vitro skin equivalent, and (b1) comparing the pigmentation (i) of the in vitro skin equivalent to which the evaluating agent is applied, with pigmentation (ii) of a control skin equivalent not subjected to the agent.
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公开(公告)号：KR1020150099818A
公开(公告)日：2015-09-01
申请号：KR1020157019688
申请日：2013-12-18
Applicant: 로레알
IPC: A61K8/60 , A61K31/70 , C07D309/10 , A61Q19/02
CPC classification number: C07D309/10
Abstract: C-자일로사이드 화합물, 조성물 및 피부의 탈색소를 위한 그의 용도. 본 발명은 하기 화학식 (I) 의 화합물을 포함하는 피부 탈색소 조성물에 관한 것이다:
여기에서:
- 화학식 (I) 의 화합물은 자일로스 유도체임.-
公开(公告)号：KR1020090099491A
公开(公告)日：2009-09-22
申请号：KR1020090022255
申请日：2009-03-16
Applicant: 로레알
CPC classification number: C12N5/0698 , C12N2501/11 , C12N2501/117 , C12N2501/39 , C12N2502/091 , C12N2502/094 , C12N2502/1323 , C12N2533/50 , C12N2533/52 , C12N2533/54 , G01N33/5088
Abstract: A method for manufacturing pigmentation skin substitute is provided, which enables to reproduce interaction of the human skin. A method for manufacturing pigmentation skin substitute comprises: a step for performing incubation for enough period to obtain the contracted collagen matrix comprising the bioartificial skin after bringing fibroblast into contact with collagen solution; a step of cultivating in the liquid medium after sowing the mixture of melanoblast and keratinocyte the obtained bioartificial skin; and a step of continuing the cultivation in the air-liquid interface until the multiple layering skin substitute including melanoblast is obtained on the bioartificial skin.
Abstract translation: 提供了一种制造色素沉着皮肤替代物的方法，其能够再现人类皮肤的相互作用。 用于制造色素沉着皮肤替代物的方法包括：使成纤维细胞与胶原溶液接触后，进行足够的时间孵育以获得包含生物人造皮肤的收缩胶原基质的步骤; 在获得的生物人造皮中播种黑素细胞和角化细胞混合物后，在液体培养基中培养的步骤; 以及在空气 - 液体界面中继续培养直到在生物人造皮肤上获得包括黑素细胞的多层皮肤替代物的步骤。
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