公开(公告)号：KR1020040000615A

公开(公告)日：2004-01-07

申请号：KR1020020035115

申请日：2002-06-22

Applicant: 박래길

Inventor： 박래길 ,  문병순 ,  문성록 ,  박기원

IPC: A61K36/537 ,  A61K36/234 ,  A61P39/06 ,  A61P25/00

Abstract: PURPOSE: Provided is a mixed extract of Radix Salviae miltiorrhizae and Rhizoma Cnidii which has inhibition effect on apoptotic neural cell death. Therefore, the extract is clinically useful. CONSTITUTION: A mixed extract of Radix Salviae miltiorrhizae and Rhizoma Cnidii characteristically inhibits apoptotic neural cell death by increasing the cell viability, reducing the condensation and fraction of chromosome, and decreasing the activity of Caspase-3 and the quantity of glutathione in the cell.

Abstract translation: 目的：提供丹参和枸杞的混合提取物，对凋亡性神经细胞死亡具有抑制作用。 因此，提取物在临床上是有用的。 构成：丹参和枸杞子的混合提取物通过增加细胞活力，降低染色体的缩合和分数，降低细胞中胱天蛋白酶-3的活性和谷胱甘肽的含量，特征性地抑制凋亡性神经细胞死亡。

公开(公告)号：KR1020040000651A

公开(公告)日：2004-01-07

申请号：KR1020020035166

申请日：2002-06-22

Applicant: 박래길

Inventor： 박래길 ,  문병순 ,  문성록 ,  박기원

IPC: A61K36/537 ,  A61K36/234 ,  A61P39/06 ,  A61P9/10

Abstract: PURPOSE: Provided is a mixed extract of Radix Salviae miltiorrhizae and Rhizoma Cnidii which has inhibition effect on apoptotic cardiac cell death. Therefore, the extract is clinically useful. CONSTITUTION: A mixed extract of Radix Salviae miltiorrhizae and Rhizoma Cnidii characteristically inhibits apoptotic cardiac cell death by increasing the cell viability, reducing the fraction of DNA and PARP, decreasing the activity of Caspase-3 protease and caspase-9 protease and inhibiting the damage to mitochondrial membrane potential, as well as mitochondrial cytochrome c. The extract synergistically inhibits apoptotic cardiac cell death by combined administration with the antioxidant, N-acetylcysteine(NAC).

Abstract translation: 目的：提供丹参和苦参碱的混合提取物，对凋亡性心脏细胞死亡具有抑制作用。 因此，提取物在临床上是有用的。 构成：丹参和枸杞子的混合提取物通过增加细胞活力，降低DNA和PARP的分数，降低Caspase-3蛋白酶和半胱天冬酶-9蛋白酶的活性，抑制细胞凋亡，抑制凋亡的心脏细胞死亡 线粒体膜电位，以及线粒体细胞色素c。 提取物通过与抗氧化剂N-乙酰半胱氨酸（NAC）的联合给药协同抑制凋亡性心脏细胞死亡。