公开(公告)号：KR1020150062543A

公开(公告)日：2015-06-08

申请号：KR1020130147313

申请日：2013-11-29

Applicant: 부경대학교 산학협력단 ,  대한민국(관리부서:국립수산과학원)

Inventor： 김형락 ,  신태선 ,  이민섭 ,  김성희 ,  최준형

IPC: A61K36/03 ,  A61P25/28 ,  A61P25/00

Abstract: 본발명은외톨개모자반추출물및 외톨개모자반에서분리된사가크로메놀 (sargachromenol)을유효성분으로포함하는퇴행성신경질환의예방또는치료용조성물에관한것이다. 본발명의외톨개모자반을이용하여얻은추출물과이로부터분리한사가크로메놀은일산화질소(NO), 프로스타글란딘 E(prostaglandin E, PGE) 및염증성사이토카인의생성을억제할뿐만아니라 iNOS 및 COX-2이발현을효과적으로억제하는효과가있는바, 신경염증성질환의예방및 치료에유용하게이용될수 있다. 특히본 발명의외톨개모자반은천연물로서세포독성없이안정성을가지므로이를유효성분으로포함하는본 발명의조성물은인체에부작용이없이장기적사용에도안전한이점을가진다.

Abstract translation: 本发明涉及用于预防或治疗退行性神经疾病的组合物，其含有从Myagropsis myagroides分离的Myagropsis myagroides提取物和sargachromeneol作为活性成分。 通过使用从本发明相同的Myagropsis myagroides和sargachromene获得的提取物显示出有效抑制一氧化氮（NO），前列腺素E_2（PGE_2）和炎性细胞因子的产生以及iNOS和COX-2的表达的效果， 因此可用于预防和治疗退行性神经疾病。 特别地，本发明的Myagropsis myagroides是天然物质，并且具有无细胞毒性的稳定性。 因此，作为本发明的活性成分的包括Myagropsis myagroides提取物和sargachromeneol的组合物对人体没有副作用，即使长时间使用也是安全的。

公开(公告)号：KR1020130031971A

公开(公告)日：2013-04-01

申请号：KR1020110095573

申请日：2011-09-22

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  이민섭 ,  신태선 ,  박시향 ,  우희철

IPC: A61K8/97 ,  A61K8/34 ,  A61Q19/02 ,  A61Q19/00

CPC classification number: A61K8/9706 ,  A61K2800/805 ,  A61Q19/02

Abstract: PURPOSE: A pharmaceutical composition containing an alcohol extract of Sargassum fulvellum, and an n-hexane soluble extract or a dichloromethane soluble extract is provided to suppress melanogenesis induced by alpha-MSH, and to ensure a skin whitening effect. CONSTITUTION: A cosmetic composition for skin whitening contains one or more extracts selected from an alcohol extract of Sargassum fulvellum, an n-hexane soluble extract, and a dichloromethane soluble extract. A pharmaceutical composition for treating pigmentary skin disorders contains one or more extracts selected from the alcohol extract of Sargassum fulvellum, the n-hexane soluble extract, and the dichloromethane soluble extract. Functional food for skin whitening contains one or more extracts selected from the alcohol extract of Sargassum fulvellum, the n-hexane soluble extract, and the dichloromethane soluble extract. [Reference numerals] (AA) Sargassum fulvellum; (BB) Drying in the shade; (CC) Powder; (DD) Reflux condensing extraction(Repeating 3 times); (EE) Using ethanol; (FF) Extraction; (GG) Vacuum filtration; (HH) Vacuum rotary concentration; (II) 40°C(Removing an organic solvent); (JJ) Crude extract(Ethanol extract); (KK) Organic solvent soluble fraction(Repeating 3-4 times); (LL) N-hexane soluble extract; (MM,OO) Water soluble fraction; (NN) Dichloromethane soluble extract;

Abstract translation: 目的：提供含有马鞭草醇提取物和正己烷可溶性提取物或二氯甲烷可溶性提取物的药物组合物，以抑制由α-MSH诱导的黑素生成，并确保皮肤美白效果。 构成：用于皮肤美白的化妆品组合物含有一种或多种提取物，其选自马鞭草醇提取物，正己烷可溶提取物和二氯甲烷可溶提取物。 用于治疗色素性皮肤病的药物组合物含有一种或多种选自马鞭草酒精提取物，正己烷可溶提取物和二氯甲烷可溶提取物的提取物。 用于皮肤美白的功能性食品包含一种或多种选自马鞭草醇提取物，正己烷可溶提取物和二氯甲烷可溶提取物的提取物。 （附图标记）（AA）马鞭草 （BB）在树荫下干燥; （CC）粉; （DD）回流冷凝萃取（重复3次）; （EE）使用乙醇; （FF）提取; （GG）真空过滤; （HH）真空旋转浓度; （II）40℃（去除有机溶剂）; （JJ）粗提取物（乙醇提取物）; （KK）有机溶剂可溶成分（重复3-4次）; （LL）N-己烷可溶提取物; （MM，OO）水溶性成分; （NN）二氯甲烷可溶提取物;

公开(公告)号：KR1020120054577A

公开(公告)日：2012-05-30

申请号：KR1020120038386

申请日：2012-04-13

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  김아름 ,  권미성 ,  최재수 ,  신태선 ,  변대석 ,  우희철

IPC: C07D493/04 ,  A61K36/03 ,  A61K31/357 ,  A61P29/00

Abstract: PURPOSE: A composition containing phlorotannins derived from Ecklonia stolonifera and Ecklonia cava extract is provided to suppress iNOS and COX-2 expression and to prevent and treat inflammatory diseases. CONSTITUTION: A phlorofucofuroeckol A compound of chemical formula I is isolated from Ecklonia stolonifera and Ecklonia cava extract. A method for isolating and purifying the compound of chemical formula I comprises: a step of extracting ethanol extract of Ecklonia stolonifera and Ecklonia cava with n-hexane to prepare hexane water soluble extract; a step of extracting the hexane water soluble extract with ethyl acetate. The Ecklonia stolonifera and Ecklonia cava extract includes crude extract or non-polar solvent soluble extract. The crud extract is prepared using water, ethanol, methanol, butanol, or mixture thereof.

Abstract translation: 目的：提供一种含有源自Ecklonia stolonifera和Ecklonia cava提取物的光合色素的组合物，以抑制iNOS和COX-2的表达，并预防和治疗炎症性疾病。 化学式I化学式I化合物是从Ecklonia stolonifera和Ecklonia cava提取物中分离出来的。 用于分离和纯化化学式I化合物的方法包括：用正己烷萃取Ecklonia stolonifera和Ecklonia cava的乙醇提取物以制备己烷水溶性提取物的步骤; 用乙酸乙酯萃取己烷水溶性提取物的步骤。 Ecklonia stolonifera和Ecklonia cava提取物包括粗提物或非极性溶剂可溶性提取物。 粗提取物用水，乙醇，甲醇，丁醇或其混合物制备。

公开(公告)号：KR1020120111813A

公开(公告)日：2012-10-11

申请号：KR1020110030402

申请日：2011-04-01

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  이민섭 ,  신태선 ,  변대석 ,  최재수

IPC: A61K8/97 ,  A61K36/03 ,  A61Q19/02 ,  A61P17/00

CPC classification number: A61K8/9706 ,  A61K9/0014 ,  A61K36/03 ,  A61Q19/02

Abstract: PURPOSE: A composition containing Ecklonia stolonifera or Ecklonia cava spirit extract is provided to suppress tyrosinase expression and melanogenesis. CONSTITUTION: A composition with a whitening effect contains Ecklonia stolonifera spirit extract as an active ingredient. The Ecklonia stolonifera spirit extract is used as a material for a cosmetic product for skin whitening, a pharmaceutical product for treating hyperpigmentary dermatitis, and a functional food for whitening. The composition also contains Ecklonia cava spirit extract as an active ingredient. The composition additionally contains dieckol or phlorofucofuroeckol A as an active ingredient. [Reference numerals] (AA) Ecklonia stolonifera/Ecklonia cava; (BB) Drying in the shade; (CC) Powder; (DD) - reflux condensing extraction(repeat three times) - using spirit; (EE) Extraction; (FF) Filtering by reduced pressure; (GG) - vacuum rotary concentration - 40°C(removing organic solvent); (HH) Ecklonia stolonifera/Ecklonia cava crude extract; (II) Organic solvent soluble fraction(repeat 3-4 times); (JJ) N-hexane soluble extract; (KK) Water soluble fraction; (LL) Dichloromethane soluble extract; (MM) Water soluble fraction; (NN) Ethyl acetate soluble extract; (OO) Water soluble fraction

Abstract translation: 目的：提供含有Ecklonia stolonifera或Ecklonia cava spirit提取物的组合物，以抑制酪氨酸酶的表达和黑素生成。 构成：具有美白作用的组合物含有Ecklonia stolonifera精神提取物作为活性成分。 Ecklonia stolonifera精油提取物用作皮肤美白化妆品的材料，用于治疗色素性皮炎的药物和美白功能性食品。 该组合物还含有Ecklonia cava精华提取物作为活性成分。 该组合物另外含有甲羟戊酸或间苯三酚甲醇作为活性成分。 （AA）Ecklonia stolonifera / Ecklonia cava; （BB）在树荫下干燥; （CC）粉; （DD） - 回流冷凝提取（重复三次） - 使用精神; （EE）提取; （FF）减压过滤; （GG） - 真空旋转浓度-40℃（去除有机溶剂）; （HH）Ecklonia stolonifera / Ecklonia cava粗提物; （二）有机溶剂可溶成分（重复3-4次）; （JJ）N-己烷可溶提取物; （KK）水溶性成分; （LL）二氯甲烷可溶提取物; （MM）水溶性成分; （NN）乙酸乙酯可溶提取物; （OO）水溶性成分

公开(公告)号：KR1020110035127A

公开(公告)日：2011-04-06

申请号：KR1020090092697

申请日：2009-09-29

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  김아름 ,  권미성 ,  최재수 ,  신태선 ,  변대석 ,  우희철

IPC: A61K36/03 ,  A61P29/00 ,  A23L1/30 ,  A61K31/357

CPC classification number: A61K36/03 ,  A23L29/035 ,  A61K31/357 ,  A61K2236/30 ,  Y10S514/886

Abstract: PURPOSE: A composition containing Ecklonia stolonifera OKAMURA and ecklonia cava extract is provided to suppress iNOS and COX-2 expression. CONSTITUTION: A composition for suppressing inflammation contains Ecklonia stolonifera OKAMURA and ecklonia cava extract. The composition contains hexane extract of Ecklonia stolonifera OKAMURA and ecklonia cava using water, low alcohol or mixture solvent. A pharmaceutical composition or functional food composition for suppressing inflammation contains phlorotannin isolated and purified from crude extract or non-polar solvent soluble extract of Ecklonia stolonifera OKAMURA and ecklonia cava. A pharmaceutical composition contains phlorofucofuroeckol A compound as an active ingredient.

Abstract translation: 目的：提供含有Ecklonia stolonifera OKAMURA和ecklonia cava提取物以抑制iNOS和COX-2表达的组合物。 构成：用于抑制炎症的组合物含有Ecklonia stolonifera OKAMURA和ecklonia cava提取物。 该组合物含有水，低醇或混合溶剂的Ecklonia stolonifera OKAMURA和ecklonia cava的己烷提取物。 用于抑制炎症的药物组合物或功能性食品组合物包含从粗提物或Ecllonia stolonifera OKAMURA和ecklonia cava的非极性溶剂可溶性提取物中分离和纯化的氯氰青霉素。 药物组合物含有作为活性成分的间苯二酚甲醇A化合物。

公开(公告)号：KR101301190B1

公开(公告)日：2013-08-29

申请号：KR1020110039212

申请日：2011-04-26

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  이민섭 ,  신태선 ,  변대석 ,  최재수

IPC: A61K36/03 ,  A61P25/32 ,  A61P1/16

Abstract: 본 발명은 곰피 또는 감태 주정 추출물로부터 분리된 플로로탄닌류를 함유하는 알콜성 간손상에 대한 간보호용 조성물에 관한 것으로, 보다 구체적으로는 곰피 또는 감태 주정 추출물에 함유된 플로로탄닌류가 알콜에 의한 HepG2 간세포 손상에 대하여 간세포 사멸 억제효과를 갖는 간 보호용 조성물에 관한 것이다.

公开(公告)号：KR1020120131508A

公开(公告)日：2012-12-05

申请号：KR1020110049714

申请日：2011-05-25

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  이민섭 ,  신태선 ,  우희철

IPC: A61K8/97 ,  A61K36/02 ,  A61Q19/02 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A23V2250/202 ,  A61K36/03 ,  A61K2236/33 ,  A61Q19/02 ,  Y10S514/844

Abstract: PURPOSE: A Laminaria japonica-derived composition for whitening is provided to suppress melanogenesis in melanoma cells and to be used in a functional cosmetic product, functional food, or pharmaceutical composition for whitening. CONSTITUTION: A cosmetic composition for skin whitening contains Laminaria japonica spirit extract, n-hexane soluble extract, or dichloromethane soluble extract as an active ingredient. A pharmaceutical composition for treating pigmentary disorders contains the Laminaria japonica spirit extract, n-hexane soluble extract, or dichloromethane soluble extract as an active ingredient.

Abstract translation: 目的：提供一种美白的粳稻组合物，用于抑制黑素瘤细胞中的黑素生成，并用于功能性化妆品，功能性食品或美白用药物组合物中。 构成：用于皮肤美白的化妆品组合物含有aria粳精神提取物，正己烷可溶提取物或二氯甲烷可溶性提取物作为活性成分。 用于治疗色素障碍的药物组合物含有作为活性成分的j粳精神提取物，正己烷可溶性提取物或二氯甲烷可溶性提取物。

公开(公告)号：KR1020120121308A

公开(公告)日：2012-11-05

申请号：KR1020110039212

申请日：2011-04-26

Applicant: 부경대학교 산학협력단

Inventor： 김형락 ,  이민섭 ,  신태선 ,  변대석 ,  최재수

IPC: A61K36/03 ,  A61P25/32 ,  A61P1/16

Abstract: PURPOSE: A hepatoprotection composition containing phlorotannins isolated from Ecklonia stolonifera or Ecklonia cava extract is provided to be used as a pharmaceutical composition for preventing and treating liver diseases. CONSTITUTION: A hepatoprotection composition which suppresses hepatocyte injury due to alcohol contains spirit extract of Ecklonia stolonifera or Ecklonia cava as an active ingredient. A health food composition for hepatoprotection contains the spirit extract of Ecklonia stolonifera or Ecklonia cava as an active ingredient. A pharmaceutical composition for hepatoprotection contains phlorotannin compounds as an active ingredient, isolated and purified from an ethyl acetate fraction of Ecklonia stolonifera or Ecklonia cava. The phlorotannin compounds are eckol, dieckol, dioxynodehydroeckol, phlorofucofuroeckol A, and phlorofucofuroeckol B. [Reference numerals] (AA) Ecklonia stolonifera and Ecklonia cava; (BB) Shade drying; (CC) Powder; (DD) Reflux extraction(repeat three times), using spirit; (EE) Extraction; (FF) Filtering at reduced pressure; (GG) Vacuum concentration, 40°C(removing organic solvent); (HH) Crude extract of Ecklonia stolonifera and Ecklonia cava; (II) Organic solvent soluble fraction(repeat 3-4 times); (JJ) N-hexane soluble extract; (KK) Water soluble fraction; (LL) Dichloromethane soluble extract; (MM) Water soluble fraction; (NN) Ethyl acetate soluble extract; (OO) Water soluble fraction

Abstract translation: 目的：提供一种含有从Ecklonia stolonifera或Ecklonia cava提取物中分离的嗜氯光亮素的肝保护组合物，用作预防和治疗肝脏疾病的药物组合物。 构成：抑制酒精肝细胞损伤的肝保护组合物含有Ecklonia stolonifera或Ecklonia cava的精神提取物作为活性成分。 用于肝保护的保健食品组合物含有Ecklonia stolonifera或Ecklonia cava的精神提取物作为活性成分。 用于肝保护的药物组合物含有作为活性成分的顺铂单宁化合物，从Ecklonia stolonifera或Ecklonia cava的乙酸乙酯部分分离和纯化。 顺铂单宁化合物是eckol，甲羟戊酸，二羟基脱氢羟克洛芬，间苯二酚，甲氧基甲醇和苯氧氟喹诺酮B.参考标号（AA）Ecklonia stolonifera和Ecklonia cava; （BB）树荫干燥; （CC）粉; （DD）回流提取（重复三次），使用精神; （EE）提取; （FF）减压过滤; （GG）真空浓度40℃（去除有机溶剂）; （HH）Ecklonia stolonifera和Ecklonia cava的粗提物; （二）有机溶剂可溶成分（重复3-4次）; （JJ）N-己烷可溶提取物; （KK）水溶性成分; （LL）二氯甲烷可溶提取物; （MM）水溶性成分; （NN）乙酸乙酯可溶提取物; （OO）水溶性成分