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1.发明申请지치 추출물을 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 审中-公开用于预防或治疗包含RADIX LITHOSPERMI SEU ARNEBIAE EXTRACT作为活性成分的癌症的药物组合物
公开(公告)号：WO2013025004A2
公开(公告)日：2013-02-21
申请号：PCT/KR2012/006359
申请日：2012-08-10
CPC classification number: A61K36/30 , A61K31/352
Abstract: 본 발명은 지치 추출물을 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로서, 보다 상세하게 본 발명은 지치 추출물, 지치의 헥산 추출물 또는 시코닌계 화합물을 유효성분으로 함유하는 암 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 지치 추출물 및 상기 추출물로부터 분리된 시코닌계 화합물은 결장암, 흑색종, 위암, 간암, 육종암 및 유방암 등 각종 암 세포의 세포증식 억제 효과를 가지며, 세포 주기 억류 효과 및 세포 사멸 인자의 발현 촉진 효과를 가짐으로써 종래 항암제에 비해 우수한 항암 활성을 가지며, 또한 천연 유래의 성분으로서 부작용이 없고 체내 안정한 특징이 있다. 따라서 본 발명에 따른 지치 헥산 추출물 및 상기 추출물로부터 분리된 시코닌계 화합물은 각종 암의 예방 및 치료를 위한 항암제의 제조에 유용하게 사용할 수 있는 효과가 있다.
Abstract translation: 本发明涉及一种用于预防或治疗癌症的药物组合物，其包含山茱萸提取物作为活性成分。 更具体地说，本发明涉及用于预防或治疗癌症的药物组合物，其含有紫草提取物，苦参碱的己烷提取物或紫草素类化合物作为活性成分。 根据本发明的提取物分离的紫草提取物和基于紫草素的化合物具有抑制结肠癌，黑素瘤，胃癌，肝癌，唾液癌和乳腺癌等各种癌症细胞增殖的作用 具有细胞周期阻滞作用和促进凋亡因子表达的作用，因此抗癌活性优于常规抗癌药物，天然衍生成分不具有副作用， 在体内是稳定的。 因此，根据本发明的提取物中分离出的苦参提取物和基于紫草素的化合物可用于制备用于预防或治疗各种癌症的抗癌药物。
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Patent Agency Ranking
公开(公告)号：KR1020120052011A
公开(公告)日：2012-05-23
申请号：KR1020100113437
申请日：2010-11-15
Applicant: 부산대학교 산학협력단
IPC: A61K31/201 , A61P29/00
CPC classification number: G01N33/5008 , A61K31/201 , G01N2500/00
Abstract: PURPOSE: A pharmaceutical composition containing ethyl linoleate is provided to suppress expression of inflammation expression marker genes and to treat inflammation. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammation contains ethyl linoleate as an active ingredient. The composition suppresses expression of inflammation expression marker genes including COX-2(cyclooxygenase-2), IL-8beta(interleukin 1-beta), iNOS(inducible NO synthase), IL-6(interleukin-6), TNF-alpha(tumor necrosis factor-alpha), NF-kappaB(nuclear factor-kappaB), or IL-12(interleukin-12).
Abstract translation: 目的：提供含有亚油酸乙酯的药物组合物，以抑制炎症表达标记基因的表达和治疗炎症。 构成：用于预防和治疗炎症的药物组合物含有亚油酸乙酯作为活性成分。 该组合物抑制包括COX-2（环氧合酶-2），IL-8β（白介素1-β），iNOS（诱导型NO合成酶），IL-6（白细胞介素-6），TNF-α（肿瘤）的炎症表达标志物基因的表达 坏死因子-α），NF-κB（核因子-κB）或IL-12（白细胞介素-12）。
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公开(公告)号：KR101342082B1
公开(公告)日：2013-12-18
申请号：KR1020100113437
申请日：2010-11-15
Applicant: 부산대학교 산학협력단
IPC: A61K31/201 , A61P29/00
Abstract: 본발명은에틸리노레이트(ethyl linoleate)를유효성분으로포함하는염증예방및 치료용약학적조성물에관한것으로, 본발명에따른에틸리노레이트는면역세포인대식세포에서 LPS에의해유도된염증자극에의해급격히증가한염증발현표지유전자들의발현을억제하는효과를가지므로, 이를포함하는조성물은염증질환의치료에효과적인의약품으로유용하게이용될수 있다.
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4.发明公开맥문동 추출물, 이의 분획물, 또는 이로부터 분리한 화합물을 유효성분으로 포함하는 항염증 활성을 가지는 조성물 无效包含LIRIOPE PLYYPYLLA提取物的组合物，其分离的化合物或具有抗炎活性的化合物
公开(公告)号：KR1020120068522A
公开(公告)日：2012-06-27
申请号：KR1020100130183
申请日：2010-12-17
Applicant: 부산대학교 산학협력단
IPC: A61K36/896 , A61K36/8968 , A61P29/00
Abstract: PURPOSE: A composition containing Liriope platyphylla extract, fraction thereof, or compounds isolated from the same is provided to effectively prevent or treat inflammatory diseases. CONSTITUTION: A composition with anti-inflammatory function contains Liriope platyphylla extract, fraction thereof, or compounds isolated from the same as an active ingredient. The extract is prepared using water, low carbon number alcohol, and mixture solvent thereof. The low carbon number alcohol is hexane or ethyl acetate. The compound is hydroxypropyl cellulose. A pharmaceutical composition for preventing and treating inflammation contains the extract, fraction, or compound as an active ingredient.
Abstract translation: 目的：提供含有Liriope platyphylla提取物，其级分或从其分离的化合物的组合物以有效预防或治疗炎症性疾病。 构成：具有抗炎功能的组合物含有Liriope platyphylla提取物，其级分或与其相同的活性成分分离的化合物。 提取物是使用水，低碳数醇及其混合溶剂制备的。 低碳数醇是己烷或乙酸乙酯。 该化合物是羟丙基纤维素。 用于预防和治疗炎症的药物组合物含有作为活性成分的提取物，级分或化合物。
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公开(公告)号：KR1020140098057A
公开(公告)日：2014-08-07
申请号：KR1020147009396
申请日：2012-08-10
Applicant: 부산대학교 산학협력단
CPC classification number: A61K36/30 , A61K31/352
Abstract: The present invention relates to a pharmaceutical composition including a Lithospermum erythrorhizon extract as an active ingredient for preventing or treating cancer. More specifically, the present invention relates to a pharmaceutical composition containing a Lithospermum erythrorhizon extract, a hexane extract of Lithospermum erythrorhizon, or a shikonin-based compound as an active ingredient for preventing or treating cancer. The Lithospermum erythrorhizon extract and the shikonin-based compound isolated from the extract according to the present invention have effects in controlling the proliferation of cancer cells including colon carcinoma, melanoma, gastric cancer, liver cancer, sarcomatosis, and breast cancer, controlling cell cycles, and promoting the expression of cell death factors so as to have excellent anti-cancer activities compared to existing anti-cancer agents. Naturally derived components therein do not have side effects and are in vivo stable. Accordingly, the Lithospermum erythrorhizon hexane extract and the shikonin-based compound isolated from the extract can be practically used in producing an anti-cancer agent for preventing and treating several kinds of cancer.
Abstract translation: 本发明涉及一种药物组合物，其包含紫草素红景天提取物作为预防或治疗癌症的有效成分。 更具体地说，本发明涉及含有紫草红精提取物，赤霉素的己烷提取物或紫草素类化合物作为预防或治疗癌症的活性成分的药物组合物。 从本发明提取物中分离出的紫草素提取物和紫草素类化合物具有控制癌细胞增殖的作用，包括结肠癌，黑素瘤，胃癌，肝癌，肉瘤瘤和乳腺癌，控制细胞周期， 促进细胞死亡因子的表达，与现有的抗癌药相比具有优异的抗癌活性。 其中天然衍生的成分不具有副作用并且在体内稳定。 因此，从提取物中分离出的紫草红己烷提取物和紫草素类化合物可以实际应用于制备预防和治疗多种癌症的抗癌剂。
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公开(公告)号：KR1020110007370A
公开(公告)日：2011-01-24
申请号：KR1020090064865
申请日：2009-07-16
Applicant: 부산대학교 산학협력단
IPC: A61K31/357 , A61P35/00 , A61K36/79 , A61P1/16
Abstract: PURPOSE: An anticancer composition containing gomisin N is provided to treat liver cancer by inducing apoptosis of hepatoma cells. CONSTITUTION: An anticancer composition contains gomisin N as an active ingredient, which is isolated from Schisandra chinensis. A pharmaceutical composition is produced in the form of powders, granules, tablet, capsules, suspensions, emulsions, syrups, aerosol oral formulations, suppositories, or transdermal formulations. The composition is administered at 10~100ug/kg/day.
Abstract translation: 目的：提供含有乳球蛋白N的抗癌组合物，通过诱导肝癌细胞的凋亡来治疗肝癌。 构成：抗癌组合物含有作为活性成分的戈希西素N，其从五味子中分离出来。 以粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆剂，气溶胶口服制剂，栓剂或透皮制剂的形式制备药物组合物。 组合物以10〜100ug / kg /天施用。
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