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    DARPin을 포함하는 이중 특이 키메라 단백질
    6.
    发明公开
    DARPin을 포함하는 이중 특이 키메라 단백질 审中-实审
    具有DARPins的双特异性嵌合蛋白

    公开(公告)号：KR1020150013084A

    公开(公告)日：2015-02-04

    申请号：KR1020140095090

    申请日：2014-07-25

    Applicant: 삼성전자주식회사

    Inventor： 정광호 ,  이승현 ,  고영준 ,  김민경 ,  황재웅 ,  조미영 ,  이정욱 ,  린포웨이

    IPC: C07K16/46 ,  C07K19/00 ,  A61K39/395

    CPC classification number: C07K16/2863 ,  C07K14/705 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/33

    Abstract: The present invention relates to a use of manufacturing of a bispecific chimeric protein including DARPin (bispecific antibody zygocyte). The bispecific chimeric protein manufactured by using DARPin has reduced side effects (agonism) and/or has the increased effects. Provided in an embodiment of the present invention is a bispecific chimeric protein which includes (a) DARPin and (b) an antibody (for example, an antibody of an lgG form), an antibody fragment (an antigen-binding fragment, for example an antibody of scFv-Fc form), or a combination of the same. Provided in another embodiment is a method for manufacturing a bispecific chimeric protein which comprises the step of connecting (a) DARPin to (b) an antibody (for example, an antibody of an lgG form), an antibody fragment (for example, an antibody of scFv-Fc form), or a combination of the same.

    Abstract translation: 本发明涉及制备包含DARPin（双特异性抗体合子）的双特异性嵌合蛋白的用途。 通过使用DARPin制造的双特异性嵌合蛋白具有减少的副作用（激动）和/或具有增加的效果。 在本发明的一个实施方案中提供了双特异性嵌合蛋白，其包括（a）DARPin和（b）抗体（例如，IgG型抗体），抗体片段（抗原结合片段，例如 scFv-Fc形式的抗体）或其组合。 在另一个实施方案中提供了一种制备双特异性嵌合蛋白的方法，其包括将（a）DARPin连接到（b）抗体（例如，IgG型抗体），抗体片段（例如抗体 的scFv-Fc形式），或其组合。

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