公开(公告)号：KR1020100002742A

公开(公告)日：2010-01-07

申请号：KR1020080062756

申请日：2008-06-30

Applicant: 서강대학교산학협력단 ,  연세대학교 산학협력단

Inventor： 정현식 ,  윤두희 ,  정광환 ,  김정호 ,  박도영

IPC: G01N33/48 ,  G01N21/25 ,  G01N21/47

Abstract: PURPOSE: A method and an apparatus for imaging raman signal of cell or biological tissue is provided to diagnose deformation and use for early diagnosis of cancer and biochemical variation. CONSTITUTION: A method for imaging raman signal of cell or biological tissue comprises: a step of emitting light of visible light wave length range; a step of make incidence of light to a point of the cell or biological tissue; a step of filtering the light of light source wave; a step of sending the light to a first charge-coupled device(CCD) and detecting raman signal; a step of converting position of point to detect raman signal; and a step of collecting raman signal obtained from each point and converting in an image of cell or biological tissue. An apparatus for imaging the raman signal of biological tissue or cell comprises: a first light source generating laser; a spatial filter enhancing laser bean diameter; a beam splitter which is optically connected to the spatial filter; a motion controller controlling position of the sample; a filter which filters light of light source wave length; and a monochromator which separats spectrum of light through the filter.

Abstract translation: 目的：提供一种用于成像细胞或生物组织的拉曼信号成像的方法和装置，用于诊断变形和用于癌症早期诊断和生化变化。 构成：用于对细胞或生物组织的拉曼信号成像的方法包括：发射可见光波长范围的光的步骤; 将光发射到细胞或生物组织的一个点的步骤; 过滤光源波的一个步骤; 将光发送到第一电荷耦合器件（CCD）并检测拉曼信号的步骤; 转换点位置以检测拉曼信号的步骤; 以及从每个点收集拉曼信号并转换成细胞或生物组织的图像的步骤。 一种用于对生物组织或细胞的拉曼信号进行成像的装置包括：第一光源产生激光; 增强激光豆直径的空间滤波器; 光学分离器，光学连接到空间滤光器; 控制样品位置的运动控制器; 滤光器，其过滤光源波长的光; 以及通过滤光器分离光谱的单色仪。