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公开(公告)号：KR1020150133317A
公开(公告)日：2015-11-30
申请号：KR1020140059559
申请日：2014-05-19
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/24 , C12N5/0081 , C12N5/06 , C12N5/0668
Abstract: 본발명은상피세포가간엽세포와혼합되어있을때 혼합물에서상피세포나간엽세포를용이하게분리하는방법에관한것이다. 상피세포와간엽세포의분리는종양조직, 배아조직, 줄기세포분화물등에서유용하게사용될수 있다. 본발명은상피세포와간엽세포가기질에차별적으로부착하는특성, 미약하게부착한간엽세포를상피세포와차별적으로견고하게부착시킬수 있는방법, 미약하게부착한상피세포를차별적으로세포사멸시킬수 있는방법을이용하여상피세포와간엽세포를분리하는방법을제공한다.
Abstract translation: 本发明涉及当与上皮细胞和间充质细胞混合时从混合物中容易地分离上皮细胞或间充质细胞的方法。 间充质细胞和上皮细胞的分离可用于干细胞的肿瘤组织，胚胎组织和分化材料。 因此，本发明提供了通过使用上皮细胞和间充质细胞不同地附着在基质上的性质来分离上皮细胞和间充质细胞的方法，稳定地和不同地附着上皮细胞和间充质细胞的方法， 以及不同程度诱导上皮细胞的细胞死亡的方法。
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公开(公告)号：KR1020150133314A
公开(公告)日：2015-11-30
申请号：KR1020140059538
申请日：2014-05-19
Applicant: 서울대학교산학협력단
Abstract: 본발명은상피성종양세포의세포간결합의소실을억제하거나유도하는물질의모니터링에사용할수 있는세포배양기질에관한것으로서, 더욱자세하게는, fibronectin을도포한세포배양용기질이 fibronectin 도포용량에의존적으로세포간결합을소실하게하거나유지하는현상을이용하여, 세포간결합을소실하는조건에서는세포간결합을유지하는물질을검색하고, 세포간결합을유지하는조건에서는세포간결합소실을유도하는물질을검색하는방법에관한것이다.
Abstract translation: 本发明涉及用于监测抑制或诱导上皮肿瘤细胞之间的结合分子的分子的细胞培养基质，更具体地说，涉及一种在断裂条件下保持细胞之间的结合的分子搜索方法和 通过使用纤维连接蛋白扩散的细胞培养基质在纤维连接蛋白上的扩散剂量维持或破坏细胞之间的结合的现象，在保持结合的条件下诱导细胞之间的结合。
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Patent Agency Ranking
公开(公告)号：KR1020170035576A
公开(公告)日：2017-03-31
申请号：KR1020150134596
申请日：2015-09-23
Applicant: 서울대학교산학협력단
Abstract: 본발명은세포간결합이취약한치은접합상피의세포간결합발달을유도하여접합상피의상피방어막기능을증진시키는기술에관한것이다. 치은접합상피는세포간결합이밀착되어있지않고간격이벌어져있기때문에외부에서세균이나독성물질이침투해들어올수 있는통로가될 수있다. 따라서접합상피의상피방어막기능을증진시키기위해서는치은접합상피의세포간결합을강화할필요가있다. 치은접합상피의상피간 E-cadherin 결합은 c-Jun N-terminal kinases에의해발달이억제된다. 이에본 발명은 c-Jun N-terminal kinases 활성을억제하므로서치은접합상피내세포막에 E-cadherin 결합의발달을유도하므로서접합상피의세포간결합을증진시킬수 있다.
Abstract translation: 本发明涉及通过诱导细胞间连接弱的牙龈连接上皮的细胞间连接发育来增强连接上皮的上皮屏障功能的技术。 牙龈连接处上皮细胞没有紧密连接，并且间隙间隔开，这可以是细菌和毒素从外部穿过的通道。 因此，为了增强连接上皮的上皮屏障功能，有必要加强牙龈连接上皮的细胞内结合。 上皮E-钙粘蛋白与牙龈上皮的结合受到c-Jun N端激酶的抑制。 因此，本发明可以抑制c-Jun N-末端激酶活性，因此，通过诱导结合上皮细胞膜上E-钙粘着蛋白结合的发展，可以促进结合上皮细胞的细胞间连接。
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公开(公告)号：KR101413827B1
公开(公告)日：2014-07-01
申请号：KR1020120041958
申请日：2012-04-23
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 내부에 공간을 가진 인산칼슘 지지체의 강도를 증가시키는 방법에 관한 것이다. 내부에 공간을 가진 인산칼슘 지지체는 기계적 강도가 낮아서 힘을 받는 곳에서는 파절의 우려 때문에 사용하기 어렵다. 이에 본 발명은 이와 같은 인산칼슘 지지체의 기계적 강도를 생체친화적인 방법으로 개선하기 위해 생체친화적인 중합체 박막과 인산칼슘 박막을 여려 겹으로 얇게 코팅하는 방법을 사용한다. 생체친화적인 중합체 박막과 인산칼슘 박막을 여려 겹으로 얇게 코팅한 인산칼슘 지지체는 지지체의 고유한 형태를 유지한 상태에서 기계적 강도가 증진된다.
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公开(公告)号：KR1020130119078A
公开(公告)日：2013-10-31
申请号：KR1020120041958
申请日：2012-04-23
Applicant: 서울대학교산학협력단
CPC classification number: C01B25/32 , A61L27/12 , C01P2006/90
Abstract: PURPOSE: A mechanical strength enhancing method of a calcium phosphate supporter by coating a calcium phosphate thin film and a polymeric membrane is provided to improve the mechanical strength of the calcium phosphate supporter which has the low mechanical strength and an internal space. CONSTITUTION: A manufacturing method of a calcium phosphate supporter in which the intensity is improved by having multiple coating of a calcium phosphate thin film and a polymeric membrane comprises the following steps: a step of coating the polymeric membrane which is remained after volatilizing the solvent after contacting the surface of the calcium phosphate supporter with the polymeric solution; a step of coating to the calcium phosphate thin film which is precipitated by making the coating surface of the polymeric membrane react with the supersaturated calcium phosphate ionic solution; a step of repeating the coating of polymeric membrane and the coating of the calcium phosphate thin film. [Reference numerals] (AA) PCL concentration (%); (BB) Ion solution processing time (min); (CC) Repeat (times); (DD) Post heat-processing temperature (°C); (EE) Pressurizing intensity (MPa); (FF) Average; (GG) Standard deviation; (HH) Control group; (II) Test group; (JJ,KK,LL) Room temperture
Abstract translation: 目的：提供通过涂覆磷酸钙薄膜和聚合物膜的磷酸钙载体的机械强度提高方法，以提高机械强度和内部空间低的磷酸钙载体的机械强度。 构成：通过磷酸钙薄膜和聚合物膜的多次涂覆来提高强度的磷酸钙载体的制造方法包括以下步骤：涂覆溶剂挥发后留下的聚合物膜的步骤 使磷酸钙载体的表面与聚合物溶液接触; 通过使聚合物膜的涂布表面与过饱和磷酸钙离子溶液反应而沉淀的磷酸钙薄膜的步骤; 重复聚合物膜的涂覆和磷酸钙薄膜的涂覆的步骤。 （AA）PCL浓度（％） （BB）离子溶液处理时间（min）; （CC）重复（次）; （DD）后加热温度（℃）; （EE）加压强度（MPa）; （FF）平均; （GG）标准偏差; （HH）对照组; （二）试验组; （JJ，KK，LL）室温
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公开(公告)号：KR1020100138023A
公开(公告)日：2010-12-31
申请号：KR1020090056359
申请日：2009-06-24
Applicant: 서울대학교산학협력단
Inventor： 김현만
Abstract: PURPOSE: A method for enhancing osteoblast proliferation on a nanotube surface is provided to eliminate phenomenon of low osteoblast proliferation and to enhance the proliferation of cells using a Rho-associated kinase. CONSTITUTION: A titanium oxide surface has a titanium oxide film formed on the surface of titanium metal or titanium alloy. An inhibitor of Rho-associated kinase enhances mesenchymal stem cell proliferation on the titanium oxide surface. The inhibitor of Rho-associated kinase is (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride or 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride.
Abstract translation: 目的：提供一种增强纳米管表面成骨细胞增殖的方法，以消除低成骨细胞增殖的现象，并使用Rho相关激酶增强细胞的增殖。 构成：氧化钛表面在钛金属或钛合金的表面上形成有氧化钛膜。 Rho相关激酶的抑制剂增强氧化钛表面的间充质干细胞增殖。 Rho相关激酶抑制剂是（+） - （R） - 反式-4-（1-氨基乙基）-N-（4-吡啶基）环己烷甲酰胺二盐酸盐或1-（1-羟基-5-异喹啉磺酰基）高哌嗪一盐酸盐。
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公开(公告)号：KR1020100132364A
公开(公告)日：2010-12-17
申请号：KR1020090051151
申请日：2009-06-09
Applicant: 서울대학교산학협력단
Inventor： 김현만
Abstract: PURPOSE: A method for enhancing cell viability, attachment, proliferation, and mobility is provided to enhance cell activation by treating Rho-associated kinase(ROCK) inhibitor. CONSTITUTION: A Rho-associated kinase inhibitor is used for enhancing cell activation. The cell activation includes cell attachment, cell proliferation, cell viability, and cell mobility. The Rho-associated kinase inhibitor is (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride or 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride.
Abstract translation: 目的：提供增强细胞活力，附着，增殖和迁移率的方法，以通过治疗Rho相关激酶（ROCK）抑制剂来增强细胞活化。 构成：Rho相关激酶抑制剂用于增强细胞活化。 细胞活化包括细胞附着，细胞增殖，细胞活力和细胞迁移。 Rho相关激酶抑制剂是（+） - （R） - 反式-4-（1-氨基乙基）-N-（4-吡啶基）环己烷甲酰胺二盐酸盐或1-（1-羟基-5-异喹啉磺酰基）高哌嗪一盐酸盐。
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