公开(公告)号：KR1020120124191A

公开(公告)日：2012-11-13

申请号：KR1020110041930

申请日：2011-05-03

Applicant: 서울대학교산학협력단

Inventor： 최윤재 ,  조종수 ,  강상기 ,  모아매드아리풀이슬람

IPC: A61K9/50 ,  A61K9/54 ,  A61K9/48 ,  A61K47/36

CPC classification number: A61K9/5073 ,  A61K9/0053 ,  A61K9/5031 ,  A61K9/5036 ,  A61K9/5089 ,  A61K47/34 ,  A61K47/36

Abstract: PURPOSE: A microcapsule for oral administration and a method for manufacturing the same are provided to improve mucosal adhesion and durability. CONSTITUTION: A microcapsule for oral administration contains 40-85 wt% of alginate, 5-20 wt% of poly-L-lysine, 5-20 wt% of alginate with a thiol group, and 5-20 wt% of physiologically active substance. The alginate is denoted by chemical formula 1. A method for preparing the alginate with the thiol group comprises: a step of adding L-cysteine salt to a reaction mixture; a step of adjusting pH of reacted mixture; and a step of performing dialysis of the reaction mixture. The average particle diameter of the microcapsule is 5-5000 um. A method for preparing the microcapsule comprises: a step of suspending the physiologically active substance in saline solution and adding alginate to the suspension; a step of reacting the reaction mixture in a calcium salt solution; a step of reacting the reaction mixture in a poly-L-lysine solution; and a step of coating the reaction mixture with the alginate solution containing thiol groups.

Abstract translation: 目的：提供用于口服的微胶囊及其制造方法，以改善粘膜粘附性和耐久性。 构成：用于口服给药的微胶囊包含40-85重量％的藻酸盐，5-20重量％的聚-L-赖氨酸，5-20重量％的具有硫醇基团的藻酸盐和5-20重量％的生理活性物质 。 藻酸盐由化学式1表示。用硫醇基制备藻酸盐的方法包括：向反应混合物中加入L-半胱氨酸盐的步骤; 调节反应混合物的pH的步骤; 以及进行反应混合物的透析的步骤。 微胶囊的平均粒径为5-5000μm。 制备微胶囊的方法包括：将生理活性物质悬浮在盐水溶液中并向悬浮液中加入藻酸盐的步骤; 使反应混合物在钙盐溶液中反应的步骤; 将反应混合物在聚-L-赖氨酸溶液中反应的步骤; 以及用含有硫醇基团的藻酸盐溶液涂覆反应混合物的步骤。