公开(公告)号：KR101262526B1

公开(公告)日：2013-05-08

申请号：KR1020110067606

申请日：2011-07-08

Applicant: 서울대학교산학협력단

Inventor： 김용식 ,  이상훈 ,  안용민 ,  유철승

IPC: A61N1/36 ,  A61B5/0476 ,  A61B5/0482 ,  A61N1/08

Abstract: 본발명은뇌파의표본엔트로피를이용한경련종료시점결정방법및 경련종료시점분석장치를제공하는데있다. 본발명은전기경련치료에있어서경련의종료시점을정확하고신속하게측정할수 있는장점을가진다. 또한, 본발명에따른경련종료시점및 지속시간측정방법은전기경련치료시행의치료효과를보다신뢰성있게예측하는데 이용될수 있을뿐 만아니라간질등 다른질환의뇌파검사에서도본 방법을이용하여발작의발생및 종료여부등에대한정보를제공할수 있다.

公开(公告)号：KR1020130005915A

公开(公告)日：2013-01-16

申请号：KR1020110067606

申请日：2011-07-08

Applicant: 서울대학교산학협력단

Inventor： 김용식 ,  이상훈 ,  안용민 ,  유철승

IPC: A61N1/36 ,  A61B5/0476 ,  A61B5/0482 ,  A61N1/08

CPC classification number: A61N1/36 ,  A61B5/0476 ,  A61B5/0482 ,  A61N1/08

Abstract: PURPOSE: A spasm end-point decision method using sample entropy of brain wave is provided to rapidly measure the end-point of spasm. CONSTITUTION: A spasm end-point decision method using sample entropy of brain wave comprises the following steps: obtaining brain wave change data according to time from experimentee; using starting time point information of the section after partitioning the brainwave data according to the time of 1-20 seconds; measuring the sample entropy value about the divided each section; selecting N number of sections by selecting the section having the lowest sample entropy value in order; reversely, calculating the absolute mean value of the brain wave amplitude up to 5-20 seconds before; distinguishing the status convulsivus and ratio status convulsivus; and determining the starting point of the last section as the spasm end-point.

Abstract translation: 目的：提供使用脑波样本熵的痉挛终点决策方法，快速测量痉挛的终点。 构成：使用脑波样本熵的痉挛终点决策方法包括以下步骤：根据实验者的时间获取脑波变化数据; 根据1-20秒的时间划分脑波数据后，使用该部分的开始时间点信息; 测量关于分割的每个部分的样本熵值; 通过选择具有最低样本熵值的部分来选择N个部分; 相反，计算脑波幅度的绝对平均值高达5-20秒; 区分痉挛状态和比例状态惊厥; 并将最后一节的起点确定为痉挛终点。

公开(公告)号：KR101070122B1

公开(公告)日：2011-10-05

申请号：KR1020090107243

申请日：2009-11-06

Applicant: 서울대학교산학협력단

Inventor： 김용식 ,  이상훈 ,  안용민 ,  유철승 ,  장재승

IPC: A61B5/02 ,  A61B5/0452 ,  A61B5/046

Abstract: 본발명은정신분열병환자들의심박변이도(heart rate variability, HRV)를측정하여정신분열병을진단하는장치및 방법에관한것이다. 보다구체적으로본 발명은 HRV의여러측정지표가정신분열병환자에서특징적인변화를보이는것을제시한다. HRV의측정지표중에서도 SampEn (sample entropy)은 HRV의복잡성을나타나는지표이며, LF/HF (ration of low frequency to high frequency)는 HRV에서교감신경계와부교감신경계가서로균형을이루는정도를나타낸다. SampEn과 LF/HF 측정값을이용하여정신분열병환자를특이적으로진단할수 있으며, 정신분열병치료제의스크리닝및 효능평가에이용할수 있다.

公开(公告)号：KR1020110050315A

公开(公告)日：2011-05-13

申请号：KR1020090107243

申请日：2009-11-06

Applicant: 서울대학교산학협력단

Inventor： 김용식 ,  이상훈 ,  안용민 ,  유철승 ,  장재승

IPC: A61B5/02 ,  A61B5/0452 ,  A61B5/046

Abstract: PURPOSE: A device and method for diagnosing schizophrenia using a heart rate variability measurement factor are provided to simply verify a medicine of schizophrenia. CONSTITUTION: A device and method for diagnosing schizophrenia(100) comprises a heart rate variability measurement unit(110), a database unit(120), and a processing unit(130). The heart rate variability measurement unit measure the heart rate variability of a subject. The database unit stores a diagnostic criteria of SampEn(sample entorpy) and LF/HF(low frequency/high frequency) through a clinical trials of a schizophrenic under predetermined conditions The processing unit calculates SampEn(sample entorpy) and LF/HF(low frequency/high frequency) using the measured data from the heart rate variability measurement unit and compares it with the diagnostic criteria.

Abstract translation: 目的：提供使用心率变异性测量因子诊断精神分裂症的装置和方法，以简单地验证精神分裂症药物。 构成：用于诊断精神分裂症的装置和方法（100）包括心率变异性测量单元（110），数据库单元（120）和处理单元（130）。 心率变异性测量单元测量受试者的心率变异性。 数据库单元通过预定条件下的精神分裂症临床试验存储SampEn（样本熵）和LF / HF（低频/高频）的诊断标准。处理单元计算SampEn（样本熵）和LF / HF（低频 /高频），使用来自心率变异性测量单元的测量数据并将其与诊断标准进行比较。