Abstract:
Disclosed are a watermarking device and a method to protect software copyright. The disclosed watermarking device includes: a bit line generating part generating a bit line used as a watermark; a dependent graph generating part generating two or more dependent graphs by reallocating the execution command orders based on a dependent relationship established between the partial commands of the commands in regard to a basic block forming an execution code of the software including the commands; and a basic block transforming part transforming the basic block by selecting a dependent graph of a turn corresponding to the generating bit line among the dependent graphs, and reallocating the execution order of the commands in the basic block. The turn of the selected dependent graph is used as the watermark.
Abstract:
본 발명은 신규의 융합 단백질 및 그의 용도에 관한 것으로, 더욱 구체적으로 케라티노사이트 성장인자 2(KGF2)와 피브로넥틴의 제10 유형 III 도메인(FN10)이 결합된 신규의 KGF2-FN10 융합(fusion) 단백질 및 그것의 케라티노사이트 증식 및 분화 촉진 용도 및 궁극적으로 이를 이용한 피부재생 촉진 용도에 관한 것이다. 본 발명에 따르면, KGF2-FN10 융합 단백질은 원래 KGF2와 비교하였을 때 현저히 상승된 인간 케라티노사이트의 미토게닉(mitogenic) 활성과 케라티노사이트 분화(differentiation) 활성을 나타냈다. 따라서, 본 발명의 KGF2-FN10 융합 단백질은 피부재생 촉진용 화장료 또는 약제로서 효과적으로 사용될 수 있을 것이다.
Abstract:
PURPOSE: A novel KGF2-FN10 fusion protein is provided to ensure kerationocyte differentiation and mitogenic activation and to use for cosmetic product and drug. CONSTITUTION: A KGF2-FN10 fusion protein has keratinocyte growth factor 2(KGF2) and fibronectin type 10 III domain(FN10). The KGF 2 has an amino acid sequence of sequence number 1. The FN10 has an amino acid sequence of sequence number 2. The fusion protein has an amino acid sequence of sequence number 4. A polynucleotide encoding the fusion protein has a base sequence of sequence number 3. A composition for proliferating keratinocytes and promoting differentiation of keratinocytes contains KGF2-FN10 fusion protein as an active ingredient. A composition for promoting skin regeneration contains KGF2-FN10 fusion protein as an active ingredient.