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公开(公告)号：WO2014200178A1
公开(公告)日：2014-12-18
申请号：PCT/KR2014/003770
申请日：2014-04-29
Applicant: 서울대학교산학협력단
CPC classification number: G01N33/92 , C07C57/03 , C07C59/42 , C07C59/76 , C07C409/24 , G01N33/6893 , G01N2030/8813 , G01N2800/52 , G01N2800/54 , G01N2800/7038
Abstract: 본원은 아라키돈산 및 그 유도체 검출용 물질을 포함하는 저산소증 검출 또는 저산소증 관련 질환 진단용 조성물, 키트 및 방법을 제공한다. 본원에 따른 조성물, 키트 및 방법은 생물학적 시료에서 생체 표지자의 검출을 통해 간편하고 신속하게 저산소증의 유무 검출 및 이를 이용하여, 저산소증에 의해 유발되는 질환의 예방 또는 조기 진단, 질환의 중증도, 치료 효과 판정 또는 경과추적 등에 유용하게 사용될 수 있다.
Abstract translation: 本发明提供了用于检测缺氧或诊断缺氧相关疾病的组合物，试剂盒和方法，所述组合物含有用于检测花生四烯酸的材料及其衍生物。 根据本发明的组合物，试剂盒和方法可以通过检测生物样品中的生物标志物来方便地及时地检测缺氧，因此可用于预防或早期诊断由缺氧引起的疾病， 疾病的严重程度和治疗效果，疾病的追踪等。
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Patent Agency Ranking
公开(公告)号：KR1020170055735A
公开(公告)日：2017-05-22
申请号：KR1020150158863
申请日：2015-11-12
Applicant: 서울대학교산학협력단
IPC: C12Q1/68
Abstract: 본발명은, 약물에의한간 손상진단을위한바이오마커에관한것으로서, miR-122의서열에상보적인프라이머를포함함으로써아목시실린또는클라불란산에의한간 손상을진단또는예측할수 있는키트및 간손상발생에대한정보제공방법에관한것이다.
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公开(公告)号：KR1020150007701A
公开(公告)日：2015-01-21
申请号：KR1020130082024
申请日：2013-07-12
Applicant: 서울대학교산학협력단
IPC: C12Q1/68 , G01N33/53 , G01N33/48 , G01N33/563
Abstract: The present invention provides: a composition, which includes a substance for detecting arachidonic acid and derivatives thereof, for detecting hypoxia or diagnosing diseases related to hypoxia; a kit; and a method for the same. According to the present invention, hypoxia is easily and rapidly detected by detecting a biomarker in a biological sample. Therefore, the composition, the kit, and the method can be advantageously used for preventing or early diagnosing diseases caused by hypoxia, determining severity of the disease and a treatment effect, or tracing a treatment course.The derivative of arachidonic acid is generated in a pathway of lipoxygenase of the arachidonic acid.
Abstract translation: 本发明提供：一种组合物，其包含用于检测花生四烯酸的物质及其衍生物，用于检测缺氧或诊断与缺氧有关的疾病; 一套工具 及其方法。 根据本发明，通过检测生物样品中的生物标志物容易且快速地检测缺氧。 因此，组合物，试剂盒和方法可以有利地用于预防或早期诊断由缺氧引起的疾病，确定疾病的严重程度和治疗效果，或追踪治疗过程。花生四烯酸的衍生物在 花生四烯酸的脂氧合酶途径。
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5.发明公开ＮＲ1Ｉ2 유전자의 단일염기다형을 포함하는 약물대사 예측용 폴리뉴클레오티드, 키트 및 이를 이용한 약물대사 예측 방법 无效包含NR1I2 SNPS的多核苷酸和包装盒用于预测药物代谢和预测方法
公开(公告)号：KR1020120029953A
公开(公告)日：2012-03-27
申请号：KR1020100092100
申请日：2010-09-17
Applicant: 서울대학교산학협력단
IPC: C12Q1/68 , C12N15/11 , G01N33/15 , A61K31/135
CPC classification number: C12Q1/6888 , A61K31/135 , C12Q2600/106 , C12Q2600/156 , G01N33/15
Abstract: PURPOSE: A polynucleotide for drug metabolism prediction including single nucleotide polymorphism of a nr1i2 gene, a kit and a drug metabolism prediction method using thereof are provided to increase prediction probability and predict metabolic activation of bupropion according to process of rifampin by simple confirmation of genotype. CONSTITUTION: A marker for predicting drug metabolism includes polynucleotide or complement thereof consisting of 8-200 continuous DNA sequences which respectively include 705th,34403rd, and 34823rd DNAs of polynucleotide which is represented by sequence number 1[SEQ ID NO:1]. The drug is bupropion. The drug metabolism is metabolism of the bupropion according to administration of rifampin. In the metabolism of bupropion, the bupropion is converted into hydroxybupropion. A kit for drug metabolism prediction includes a marker for the drug metabolism prediction. The drug metabolism prediction method comprises the following steps: obtaining nucleic acid sample material which includes NR1I2 gene; amplifying the polynucleotide which respectively includes 705th, 34403rd, and 34823rd DNAs of polynucleotide which is represented by sequence number 1; and determining genotype of 705th, 34403rd, and 34823rd DNAs of the polynucleotide which is represented by sequence number among the amplified polynucleotides.
Abstract translation: 目的：提供包括nr1i2基因的单核苷酸多态性，使用该试剂盒和药物代谢预测方法的药物代谢预测多核苷酸，以通过简单确认基因型来增加预防概率，并根据利福平的过程预测安非他酮的代谢活化。 构成：用于预测药物代谢的标记物包括由序列号1 [SEQ ID NO：1]表示的分别包含第705,34403rd和34823rd多核苷酸的DNA的8-200个连续DNA序列组成的多核苷酸或其补体。 药物是安非他酮 根据利福平的施用，药物代谢是安非他酮的代谢。 在安非他酮的代谢中，安非他酮被转化为羟基安非他力。 用于药物代谢预测的试剂盒包括用于药物代谢预测的标记物。 药物代谢预测方法包括以下步骤：获得包含NR1I2基因的核酸样品; 扩增分别包含序列号1表示的多核苷酸的第705,34403和34823个DNA的多核苷酸; 并确定由扩增的多核苷酸中的序列号表示的多核苷酸的第705,34403和34823rd个DNA的基因型。
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公开(公告)号：KR101770748B1
公开(公告)日：2017-08-23
申请号：KR1020150158863
申请日：2015-11-12
Applicant: 서울대학교산학협력단
IPC: C12Q1/68
Abstract: 본발명은, 약물에의한간 손상진단을위한바이오마커에관한것으로서, miR-122의서열에상보적인프라이머를포함함으로써아목시실린또는클라불란산에의한간 손상을진단또는예측할수 있는키트및 간손상발생에대한정보제공방법에관한것이다.
Abstract translation: 本发明涉及一种由药物引起的损害诊断肝的生物标志物，的miR-122 uiseo柱互补由包括底漆阿莫西林或克拉维酸可以诊断或预测在试剂盒中的肝损害和肝障 本发明涉及提供关于用户的信息的方法。
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公开(公告)号：KR101446873B1
公开(公告)日：2014-10-06
申请号：KR1020130068324
申请日：2013-06-14
Applicant: 서울대학교산학협력단
Abstract: The present invention provides a composition, a kit and a method for diagnosing sleep apnea, including material for detecting arachidonic acid and derivatives thereof. The composition, the kit and the method according to the present invention can trace progress or simply and quickly determine a symptom of sleep apnea, seriousness of illness and treatment effect through detecting biomarkers in a biological sample.
Abstract translation: 本发明提供一种用于诊断睡眠呼吸暂停的组合物，试剂盒和方法，包括用于检测花生四烯酸的物质及其衍生物。 根据本发明的组合物，试剂盒和方法可以通过检测生物样品中的生物标志物来跟踪进展或简单快速地确定睡眠呼吸暂停症状，疾病严重性和治疗效果。
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