公开(公告)号：KR1020110091278A

公开(公告)日：2011-08-11

申请号：KR1020100011036

申请日：2010-02-05

Applicant: 서울대학교산학협력단

Inventor： 박종상 ,  진근우

IPC: A61K31/365 ,  A61K38/13 ,  A61K9/20 ,  A61P37/00

Abstract: PURPOSE: An immunosuppression containing mycophenolate or derivative thereof and cyclosporine is provided to sample administration effect with a case of administering mycophenolate tablets and cyclosporine tablets. CONSTITUTION: A composite tablet contains cyclosporine and mycophenolate. The cyclosporine is cyclosporine A. The mycophenolate is mycophenolate or derivative thereof. An immunosuppressant contains 3-9 weight ratio of cyclosporine A, 29-87 weight ratio of mycophenolate mofetil, 10-30 weight ratio of hydroxypropyl methyl cellulose, 5-25 weight ratio of avicel PH101, and 1 weight ratio of stearate magnesium salt. The mycophenolate mofetil is denoted by (E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate. The hydroxypropyl methyl ceullose is a water swellable polymer.

Abstract translation: 目的：提供含有霉酚酸酯或其衍生物和环孢菌素的免疫抑制剂，用于施用霉酚酸片剂和环孢菌素片剂的样品施用效果。 构成：复合片含有环孢菌素和霉酚酸酯。 环孢菌素是环孢霉素A.霉酚酸酯是霉酚酸酯或其衍生物。 免疫抑制剂含有3-9重量比的环孢菌素A，29-87重量比的霉酚酸酯，10-30重量比的羟丙基甲基纤维素，5-25重量比的avicel PH101，和1重量比的硬脂酸镁盐。 霉酚酸酯由（E）-6-（1,3-二氢-4-羟基-6-甲氧基-7-甲基-3-氧代-5-异苯并呋喃基）-4-甲基-4-己烯酸酯表示。 羟丙基甲基纤维素是水溶胀性聚合物。