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公开(公告)号：KR1020130037608A
公开(公告)日：2013-04-16
申请号：KR1020110102107
申请日：2011-10-06
Applicant: 성균관대학교산학협력단
Abstract: PURPOSE: A recombinant microorganism for producing caproic acid and a method for producing caproic acid using the same are provided to produce high efficiency caproic acid and to manufacture bioplastic using the caproic acid. CONSTITUTION: A recombinant microorganism for producing caproic acid has enhanced beta-keto-thiolase activity by transducing foreign phbA gene, foreign bktB gene, or a combination thereof. The recombinant microorganism is E.coli, K. lactis, S. cerevisiae, or K. marxianus. A method for producing a large amount of caproic acid comprises: a step of culturing the recombinant microorganism; and a step of collecting caproic acid from the cultured cells or a culture medium.
Abstract translation: 目的：提供用于制备己酸的重组微生物和使用其的生产己酸的方法，以生产高效己酸并使用己酸制造生物塑料。 构成：通过转导外源phbA基因，外源bktB基因或其组合，用于产生己酸的重组微生物具有增强的β-酮 - 硫醇酶活性。 重组微生物是大肠杆菌，乳酸克鲁维酵母，酿酒酵母或马克斯克霉。 一种生产大量己酸的方法包括：培养重组微生物的步骤; 以及从培养的细胞或培养基中收集己酸的步骤。
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Patent Agency Ranking
公开(公告)号：KR1020140026207A
公开(公告)日：2014-03-05
申请号：KR1020120093322
申请日：2012-08-24
Applicant: 성균관대학교산학협력단
Abstract: The present invention relates to microorganisms for producing hexanol which activation of cytochrome P450 monooxygenase is enhanced and a microorganism producing method. Also, the present invention relates to a hexanol production method comprising a step of culturing the microorganisms; and a step of collecting hexanol from the cultures or microorganisms and hexanol produced therefrom. According to the present invention, an existing 1-hexanol production method has low production in spite of long-time fermentation thereby blocking an biosynthesis industry of 1-hexanol, however, as genes presented in the present invention are introduced, microorganisms which have been significantly advanced in fermentation time and production volume are provided. Accordingly, when using microorganisms, it is believed to significantly contribute to 1-hexanol bio synthesis and the growth of a bio-plastic industry and is helpful for a simple and low-cost bio-plastic production method.
Abstract translation: 本发明涉及细胞色素P450单加氧酶的活化增强的微生物和微生物的制造方法。 此外，本发明涉及包含培养微生物的步骤的己醇生产方法; 以及从培养物或微生物和由其制备的己醇收集己醇的步骤。 根据本发明，尽管长时间发酵，现有的1-己醇生产方法生产量低，从而阻断了1-己醇的生物合成工业，但是，如本发明所述的基因被引入，已经显着地显示了微生物 提供发酵时间和生产量先进。 因此，当使用微生物时，据信对生物塑料工业的1-己醇生物合成和生长有显着贡献，有助于简单且低成本的生物塑料生产方法。
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公开(公告)号：KR101884022B1
公开(公告)日：2018-08-02
申请号：KR1020110102107
申请日：2011-10-06
Applicant: 성균관대학교산학협력단
Abstract: 본발명은카프로산생산용재조합미생물및 이를이용하여카프로산을대량생산하는방법에관한것으로, 구체적으로본 발명은야생형미생물에베타-케토티오라아제(β-keto-thiolases) 활성이도입되어카프로산생산능이향상된재조합미생물, 및상기재조합미생물을배양하는단계; 및배양액으로부터카프로산을회수하는단계를포함하는카프로산의대량생산방법에관한것이다. 본발명의재조합미생물은야생형미생물에베타-케토티오라아제(β-keto-thiolases) 활성을도입하여카프로산생산능을발현하므로, 고수율및 고효율로카프로산을대량생산할수 있으며, 이와같이생성된카프로산은바이오플라스틱생산등에유용하게사용할수 있다.
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公开(公告)号：KR1020140026208A
公开(公告)日：2014-03-05
申请号：KR1020120093324
申请日：2012-08-24
Applicant: 성균관대학교산학협력단
Abstract: The present invention relates to recombinant micro-organisms for producing organic acid in which activities of acetyl-CoA acetyltransferase, β-Ketothiolase II, crotonaseand, 3-hydroxybutyryl-CoA dehydrogenase, and trans-enoyl-CoA reductase are enhanced, and to a method for producing organic acid using the same. In addition, the present invention relates to a method for producing the organic acid which includes the steps of: culturing the microorganisms; and collecting the organic acid from the microorganisms or the culture, and to the organic acid manufactured through the same. The conventional method for producing hexanoic acid has low productivity even after long term fermentation and biosynthesis of the hexanoic acid becomes difficult so that the present invention provides the microorganisms which are drastically developed in fermentation time and production amount by introducing genes provided in the present invention. By using the microorganisms, the present invention can contribute to biosynthesis of the hexanoic acid and growth of bioplastic industries caused by the same and be helpful for a novel method for producing the bioplastic which is simple and requires low costs. The present invention can drastically contribute to growth of the bioplastic industry.
Abstract translation: 本发明涉及用于生产有机酸的重组微生物，其中乙酰辅酶A乙酰转移酶，β-酮硫解酶II，巴豆酸酶，3-羟基丁酰-CoA脱氢酶和反式 - 酰基-CoA还原酶的活性增强， 用于生产使用其的有机酸。 此外，本发明涉及一种生产有机酸的方法，包括以下步骤：培养微生物; 并从微生物或培养物中收集有机酸，以及通过其生产的有机酸。 生产己酸的常规方法即使在长期发酵后也具有低生产率，并且己酸的生物合成变得困难，因此本发明通过引入本发明提供的基因提供在发酵时间和生产量上显着发展的微生物。 通过使用微生物，本发明可以有助于己酸的生物合成和由其引起的生物塑料行业的生长，并且有助于生产生物塑料的新颖方法，其简单且需要低成本。 本发明可大大有助于生物塑料工业的发展。
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