公开(公告)号：KR101075337B1

公开(公告)日：2011-10-19

申请号：KR1020090029953

申请日：2009-04-07

Applicant: 성균관대학교산학협력단

Inventor： 서광원 ,  김덕준

IPC: C08G69/48 ,  C08G69/36 ,  C08G69/00 ,  B82B3/00

Abstract: 본발명은폴리숙신이미드(PSI)에옥타데실아민, 화학식 1의 1-(3-아미노프로필)이미다졸및 화학식 2의-(2-아미노에틸)--메틸폴리에틸렌글리콜을첨가하여화학식 6의 pH 민감성폴리아스파트아미드그라프트공중합체를제조하는방법및 이에따라제조된공중합체에관한것이다. 이는, 엔도솜내부또는종양세포주변과같은 pH 6.8 이하의약 산성조건에서상전이되거나입자크기가변화하여종래의 pH 민감성이미다졸함유고분자들보다매우미세한 pH 변화에도반응할수 있을뿐만아니라, 제조방법이용이하고, 경제적이어서의료용과약물전달분야에서다양한용도로활용이가능하다.

公开(公告)号：KR1020100111496A

公开(公告)日：2010-10-15

申请号：KR1020090029953

申请日：2009-04-07

Applicant: 성균관대학교산학협력단

Inventor： 서광원 ,  김덕준

IPC: C08G69/48 ,  C08G69/36 ,  C08G69/00 ,  B82B3/00

Abstract: PURPOSE: A potential for hydrogen(pH)-sensitive poly aspartamide graft copolymer, and a manufacturing method thereof are provided to simply manufacture the copolymer with the graft reaction, and to secure the harmlessness to the human body. CONSTITUTION: A pH-sensitive poly aspartamide graft copolymer is formed with a recurring unit marked with chemical formula 6, and has the molecular weight of 34,000~53,000. A manufacturing method the pH-sensitive poly aspartamide graft copolymer comprises a step of adding octadecylamine, 1-(3-aminopropyl)imidazole, and O-(2-aminoethyl)-O'-methylpolyethylene glycol to polysuccinimide.

Abstract translation: 目的：提供氢（pH）敏感性聚天冬氨酰胺接枝共聚物的潜力及其制造方法，以简单地制造具有接枝反应的共聚物，并且确保对人体的无害性。 构成：pH值敏感的聚天冬氨酰胺接枝共聚物由具有化学式6的重复单元形成，分子量为34,000〜53,000。 pH敏感聚天冬酰胺接枝共聚物的制造方法包括向聚琥珀酰亚胺中加入十八烷基胺，1-（3-氨基丙基）咪唑和O-（2-氨基乙基）-O'-甲基聚乙二醇的步骤。