公开(公告)号：KR101374409B1

公开(公告)日：2014-03-18

申请号：KR1020110105985

申请日：2011-10-17

Applicant: 성균관대학교산학협력단

Inventor： 권대혁 ,  임희종 ,  서지희 ,  김범태 ,  김성구 ,  김준섭

IPC: A61K31/497 ,  A61K31/495 ,  A61P31/00

CPC classification number: A61K31/495 ,  A61K31/345 ,  A61K31/496 ,  Y02A50/475 ,  Y02A50/483

Abstract: 본 발명은 비유전성 항생제 내성을 가지는 미생물에게 항생제에 대한 감수성을 부여할 수 있는 화합물을 항생제와 함께 처리하여 비유전성 항생제 내성을 가지는 미생물을 사멸시키는 방법, 상기 화합물을 포함하는 항생제 내성 억제용 조성물 및 항생제와 상기 화합물을 유효성분으로 포함하는 미생물감염성 질환의 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명의 화합물은 다양한 항생제에 투여시 나타나는 비유전적 항생제 내성을 억제하여 이에 의한 2차 감염을 방지할 수 있으므로, 항생제를 이용하여 미생물감염증을 효과적으로 예방 또는 치료하는데 널리 활용될 수 있을 것이다.

公开(公告)号：KR1020130139820A

公开(公告)日：2013-12-23

申请号：KR1020130148792

申请日：2013-12-02

Applicant: 성균관대학교산학협력단

Inventor： 권대혁 ,  임희종 ,  서지희 ,  김범태 ,  김성구 ,  김준섭

IPC: A61K31/497 ,  A61K31/496 ,  A61K31/495 ,  A61K31/34 ,  A61P31/00

CPC classification number: Y02A50/475 ,  Y02A50/483 ,  A61K31/496 ,  A61K31/341 ,  A61K31/495

Abstract: The present invention relates to a method for killing microorganisms having non-inherited antibiotic resistance by processing an antibiotic with a compound which can add sensitivity for the antibiotic to the microorganism having the non-inherited antibiotic resistance; to a compound for suppressing antibiotic resistance which includes the compound; and to a pharmaceutical composition for preventing or treating microorganism infectious diseases which includes the compound as an active ingredient. The compound of the present invention suppresses the non-inherited antibiotic resistance which is shown when administered to various antibiotics in order to prevent secondary infections caused thereby and to effectively prevent or treat the microorganism infectious diseases using the antibiotic.

Abstract translation: 本发明涉及通过用具有抗生素对具有非遗传抗生素抗性的微生物增加敏感性的化合物处理抗生素来杀死具有非遗传抗生素抗性的微生物的方法; 涉及包含该化合物的抗生素抗性抑制化合物; 涉及包含该化合物作为有效成分的微生物感染性疾病的预防或治疗用药物组合物。 本发明的化合物抑制了当施用于各种抗生素时显示的非遗传性抗生素抗性，以防止由此引起的继发性感染并有效地预防或治疗使用抗生素的微生物感染性疾病。

公开(公告)号：KR1020130041613A

公开(公告)日：2013-04-25

申请号：KR1020110105985

申请日：2011-10-17

Applicant: 성균관대학교산학협력단

Inventor： 권대혁 ,  임희종 ,  서지희 ,  김범태 ,  김성구 ,  김준섭

IPC: A61K31/497 ,  A61K31/495 ,  A61P31/00

CPC classification number: A61K31/495 ,  A61K31/345 ,  A61K31/496 ,  Y02A50/475 ,  Y02A50/483

Abstract: PURPOSE: A non-inherited antibiotic resistance inhibitor and a use thereof are provided to induce apoptosis of a microbe with non-inherited antibiotic resistance. CONSTITUTION: A method for inducing apoptosis of a microbe with non-inherited antibiotic resistance comprises a step of treating the microbe with non-inherited antibiotic resistance using antibiotics and a compound with antibiotic sensitivity, which is selected from the group consisting of 4-(4-(3-chlorophenyl)piperazin-1-yl)piperidin-3-yl 2-naphthoate, 3-(4-(4-methoxyphenyl)piperazin-1-yl)piperidin-4-yl biphenyl-4-carboxylate, (E)-2-nitro-5-styrylfuran, 1-(3-(bis(4-fluorophenyl)methoxy)phenyl)piperazine, a derivative thereof, and a combination thereof. The antibiotic is selected from the group consisting of beta-lactam antibiotics, tetracycline antibiotics, quinolone antibiotics, amino glycoside antibiotics, glycopeptides antibiotics, sulfonamide antibiotics, and a combination thereof.

Abstract translation: 目的：提供非遗传性抗生素抗性抑制剂及其用途，以诱导具有非遗传抗生素抗性的微生物细胞凋亡。 构成：用非导电抗生素抗性诱导微生物细胞凋亡的方法包括使用抗生素和具有抗生素敏感性的化合物治疗具有非遗传抗生素抗性的微生物的步骤，其选自4-（4 - （3-氯苯基）哌嗪-1-基）哌啶-3-基2-萘甲酸酯，3-（4-（4-甲氧基苯基）哌嗪-1-基）哌啶-4-基联苯-4-羧酸乙酯（E ）-2-硝基-5-苯乙烯基呋喃，1-（3-（双（4-氟苯基）甲氧基）苯基）哌嗪及其衍生物及其组合。 抗生素选自β-内酰胺抗生素，四环素抗生素，喹诺酮抗生素，氨基糖苷抗生素，糖肽抗生素，磺胺类抗生素及其组合。