公开(公告)号：KR1020130117165A

公开(公告)日：2013-10-25

申请号：KR1020120040020

申请日：2012-04-17

Applicant: 성균관대학교산학협력단

Inventor： 이석찬 ,  노강산 ,  이경훈 ,  염창환

IPC: A01K67/027

CPC classification number: A01K67/033 ,  A01K2207/30

Abstract: PURPOSE: An acquired lymphedema animal model and a method for producing the same are provided to form bigger edema than the lymphedema animal and look like a real model. CONSTITUTION: An acquired lymphedema animal model uses an animal without subcutaneous and lymphatic vessel by an iron and lymphatic vessel in the right leg and the right inguinal region. The animal is mammal and especially a mouth. A manufacturing method of the same comprises the following steps. The superficial inguinal node, deep inguinal node and popliteal node are cut. The right leg lymphatic vessel is blocked. To use the iron subcutaneous and lymphatic vessel are removed.

Abstract translation: 目的：提供获得性淋巴水肿动物模型及其生产方法，以形成比淋巴水肿动物更大的水肿，并且看起来像一个真实的模型。 构成：获得性淋巴水肿动物模型通过右腿和右腹股沟区域的铁和淋巴管，使用没有皮下和淋巴管的动物。 动物是哺乳动物，特别是嘴。 其制造方法包括以下步骤。 切开腹浅腹股沟，深腹股沟和al节。 右腿淋巴管堵塞。 使用铁皮下和淋巴管取出。

公开(公告)号：KR101477858B1

公开(公告)日：2014-12-30

申请号：KR1020120040020

申请日：2012-04-17

Applicant: 성균관대학교산학협력단

Inventor： 이석찬 ,  노강산 ,  이경훈 ,  염창환

IPC: A01K67/027

Abstract: 본발명은후천성림프부종동물모델및 이의제조방법에관한것으로, 보다구체적으로는암치료를통해발생할수 있는림프계의손상을마우스에적용하여허벅지와발등에림프부종을유도하여제작한후천성림프부종동물모델및 이의제조방법에관한것이다. 본발명은기존의림프부종동물모델보다큰 부종이형성가능하고, 이로인해더 많은샘플을얻을수 있으며, 림프부종 3 phase 일때 발생하는섬유증(fibrosis)이형성되어기존의모델보다실제와가까운재현성을보이는효과가있다. 따라서실제환자의증상의완벽한재현으로전임상실험의생체시료로이용가능하며림프부종메커니즘연구에크게기여할것으로기대된다.