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1.发明公开
公开(公告)号：KR1020070010321A
公开(公告)日：2007-01-24
申请号：KR1020050064804
申请日：2005-07-18
Applicant: 성균관대학교산학협력단
IPC: C25D11/04
Abstract: A method of manufacturing porous anodic aluminum oxide of which pores are regularly shaped and aligned uniformly such that the pores are suitably used in a bio-sensor, and a bio-sensor using functionalized anodic aluminum oxide, which can detect a small quantity of beta-galactosidase within a short time by measuring optical interference variation according to concentration change of beta-galactosidase, are provided. A method of manufacturing porous anodic aluminum oxide comprises: a pretreatment step of subjecting an aluminum sample to ultrasonic cleaning using acetone and methanol respectively, and subjecting an impurity removed aluminum to heat treatment at 300 to 500 deg.C for 20 to 40 minutes; a first anodizing step of oxidizing aluminum at a voltage of 30 to 50 V in an electrolyte having a temperature of 10 to 30 deg.C for 15 to 25 minutes after installing aluminum on an anode and installing a Pb plate on a cathode; an alumina layer removal step of dipping the first oxidized aluminum into a phosphoric acid-chromic acid mixed solution comprising 4 to 8 wt.% of phosphoric acid and 1.0 to 2.5 wt.% of chromic acid and having a temperature of 60 to 70 deg.C; a second anodizing step of oxidizing aluminum again at a voltage of 30 to 50 V in an electrolyte having a temperature of 10 to 30 deg.C for 15 to 25 minutes after installing the alumina layer-removed aluminum on an anode and installing a Pb plate on a cathode; and a step of dipping a porous aluminum passing through the second anodizing step into an aqueous solution comprising 4 to 8 wt.% of phosphoric acid and having a temperature of 20 to 40 deg.C to expand pores of the porous aluminum.
Abstract translation: 一种制造多孔阳极氧化铝的方法，其中孔被规则地成形和均匀排列，使得孔适合用于生物传感器，以及使用官能化阳极氧化铝的生物传感器，其可以检测少量的β- 提供了通过根据β-半乳糖苷酶的浓度变化测量光学干涉变化在短时间内的半乳糖苷酶。 一种制造多孔阳极氧化铝的方法包括：预处理步骤，分别使用丙酮和甲醇对铝样品进行超声波清洗，并将去除的杂质的铝在300至500℃下热处理20至40分钟; 在阳极上安装铝并在其上安装Pb板之后，在具有10〜30℃的电解质的电解质中将铝氧化为15〜25分钟的第一阳极氧化工序; 将第一氧化铝浸渍到包含4至8重量％的磷酸和1.0至2.5重量％的铬酸并且具有60至70度的温度的磷酸铬酸混合溶液中的氧化铝层去除步骤。 C; 第二阳极氧化步骤，在将氧化铝层除去的铝安装在阳极上之后，在温度为10〜30℃的电解质中，在30〜50V的电压下再次氧化15〜25分钟，并安装Pb板 在阴极上 以及将通过第二阳极氧化步骤的多孔铝浸渍到包含4至8重量％的磷酸并且具有20至40℃的温度以扩大多孔铝的孔的水溶液的步骤。
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2.发明授权
公开(公告)号：KR100676089B1
公开(公告)日：2007-02-02
申请号：KR1020050064804
申请日：2005-07-18
Applicant: 성균관대학교산학협력단
IPC: C25D11/04
Abstract: 미량의 대상 물질을 짧은 시간에 검출할 수 있도록 하는 기능화된 다공성 양극산화 알루미늄을 이용한 광간섭 바이오센서가 개시되어 있다. 상기 기능화된 다공성 양극산화 알루미늄을 이용한 광간섭 바이오센서의 제조방법은, 다공성 양극산화 알루미늄을 에탄올로 세척하는 단계; 세척된 양극산화 알루미늄을 상온에서 자기조립단분자막(Self-Assembled Monolayer: SAM)방식을 이용하여 3-아미노프로필트리메토시실란(aminopropyltrimethoxysilane)를 50mM로 증류수에 녹여 아세틱산(acetic acid)를 가하여 pH 4.5로 한 후에 24시간 동안 침지하는 단계; 양극산화 알루미늄 시편을 꺼내어 세척한 후에 상온에서 1시간 동안 건조시키는 단계; 115℃에서 30분간 질소분위기하에서 다시 건조시키는 단계; 및 프로링커(Prolinker
TM )A를 CHC13에 10mM로 용해시킨 후에 용액 내에 건조된 양극산화 알루미늄을 5시간 동안 침지하는 단계;를 포함하는 것을 특징으로 한다.
다공성, 양극산화, 알루미늄, 바이오센서, 광간섭
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