公开(公告)号：KR1020090071871A

公开(公告)日：2009-07-02

申请号：KR1020070139802

申请日：2007-12-28

Applicant: 성균관대학교산학협력단

Inventor： 이선미 ,  이찬호

IPC: A61K31/19 ,  A61K31/185 ,  A61P31/00

CPC classification number: A61K31/19

Abstract: A pharmaceutical composition for treating sepsis and septic shock is provided to suppress multiple organ dysfunction syndrome related to organ damage and lower mortality. A pharmaceutical composition for treating sepsis and septic shock comprises a compound of the chemical formula 1 or its pharmaceutically allowable salt as an active ingredient. In the chemical formula 1, R1, R2, and R3 are hydrogen, or residue of the chemical formula 2. In the chemical formula 1, R4 is hydrogen, alkyl group of 1-6 carbon atoms. The compound of the chemical formula 1 is chlorogenic acid, and comprises 3-caffeoylquinic acid, 4-caffeoylquinic acid, 5-caffeoylquinic acid, 3,4-caffeoylquinic acid, 3,5-caffeoylquinic acid, or 4,5-dicaffeoylquinic acid. The pharmaceutical composition suppresses organic damage by the sepsis. The organ is liver, kidney, or heart. The pharmaceutical composition further comprises carrier, excipient, or diluents.

Abstract translation: 提供用于治疗败血症和败血性休克的药物组合物，以抑制与器官损伤相关的多器官功能障碍综合征和降低死亡率。 用于治疗败血症和败血性休克的药物组合物包含化学式1的化合物或其药学上可允许的盐作为活性成分。 在化学式1中，R 1，R 2和R 3是氢或化学式2的残基。在化学式1中，R 4是氢，1-6个碳原子的烷基。 化学式1的化合物是绿原酸，并且包含3-咖啡酰奎尼酸，4-咖啡酰奎尼酸，5-咖啡酰奎尼酸，3,4-咖啡酰奎尼酸，3,5-咖啡酰奎尼酸或4,5-二脱氧奎尼酸。 药物组合物抑制败血症的有机损伤。 器官是肝脏，肾脏或心脏。 药物组合物还包含载体，赋形剂或稀释剂。

公开(公告)号：KR1020090073462A

公开(公告)日：2009-07-03

申请号：KR1020070141414

申请日：2007-12-31

Applicant: 주식회사 코씨드바이오팜 ,  코아스템(주) ,  성균관대학교산학협력단

Inventor： 신대희 ,  정혜진 ,  이선미 ,  이찬호 ,  김경숙 ,  박성민 ,  박지영

IPC: A61K36/481

CPC classification number: A61K36/481 ,  A23V2200/31 ,  A61K2236/331 ,  A61K2236/333

Abstract: An anti-stress extract which contains an Astragali radix extract normalizes the functional variation of adrenal gland and spleen. A composition for relieving stress generated in a body comprises an Astragli radix extract as an active ingredient. The content of the Astragli radix extract is 0.01-30%(w/w). The Astragli radix extract is one among extract by cold water, extract by hot water and extract by the ethanol. The content of ethanol in ethanol solution is 5-75%(v/v). The composition is food. An anti-cotisol composition comprises the Astragli radix extract as an active ingredient.

Abstract translation: 含有黄芪提取物的抗应激提取物使肾上腺和脾脏的功能异常正常化。 用于缓解在体内产生的应激的组合物包括作为活性成分的黄芪提取物。 黄芪提取物的含量为0.01-30％（w / w）。 黄芪提取物是冷水提取物之一，热水提取，乙醇萃取。 乙醇溶液中乙醇的含量为5-75％（v / v）。 组成是食物。 抗共聚二醇组合物包含作为活性成分的黄芪提取物。

公开(公告)号：KR100841408B1

公开(公告)日：2008-06-25

申请号：KR1020070057431

申请日：2007-06-12

Applicant: 성균관대학교산학협력단

Inventor： 이선미 ,  신대희 ,  이찬호

IPC: A61K36/35 ,  A61P7/08

Abstract: A pharmaceutical composition comprising an extract of Lonicera japonica Thunberg is provided to lower death rate by inhibiting multiple organ dysfunction syndrome related to organ damage caused by sepsis with less side effects, thereby being effectively used to treat the sepsis and septic shock. A pharmaceutical composition for treating sepsis and septic shock comprises an extract of Lonicera japonica Thunberg as an effective ingredient and is characterized in that it inhibits damage of an organ caused by the sepsis, The composition further comprises a pharmaceutically acceptable carrier, excipient or diluent. Further, the organ is one or more organs of liver, kidney and heart.

Abstract translation: 提供包含忍冬种提取物的药物组合物，通过抑制由败血症引起的器官损伤的多器官功能障碍综合症，副作用较小，从而有效地用于治疗败血症和败血性休克，降低死亡率。 用于治疗败血症和败血性休克的药物组合物包含忍冬种提取物作为有效成分，其特征在于其抑制由败血症引起的器官的损伤。该组合物还包含药学上可接受的载体，赋形剂或稀释剂。 此外，器官是肝，肾和心脏的一个或多个器官。