公开(公告)号：KR1020130124270A

公开(公告)日：2013-11-13

申请号：KR1020130128011

申请日：2013-10-25

Applicant: 성균관대학교산학협력단

Inventor： 최규실 ,  서영주 ,  임현철 ,  김영선

IPC: A61K49/04 ,  A61K47/48 ,  A61K9/16

CPC classification number: A61K49/1824 ,  A61K49/14

Abstract: The present invention relates to an image material and a method for manufacturing the same and, more particularly, to an atherosclerotic plaque-specific MR image contrast agent and a method for manufacturing the same. The contrast agent of the present invention is an active contrast agent which is able to diagnose early atherosclerotic plaque and effectively realizes the atherosclerotic plaque-specific MR image by controlling the size of the phospholipid nanoparticles and extending the residence time of the phospholipid nanoparticles in the blood vessels. Also, the contrast agent is able to acquire an MR image using an amount less than the existing passive contrast agent and is able to easily diagnose diseases accompanying the atherosclerosis.

Abstract translation: 图像材料及其制造方法技术领域本发明涉及图像材料及其制造方法，更具体地，涉及动脉粥样硬化斑块特异性MR图像造影剂及其制造方法。 本发明的造影剂是能够诊断早期动脉粥样硬化斑块并有效实现动脉粥样硬化斑块特异性MR图像的活性造影剂，其通过控制磷脂纳米颗粒的尺寸并延长磷脂纳米颗粒在血液中的停留时间 船只。 此外，造影剂能够使用小于现有被动造影剂的量获得MR图像，并且能够容易地诊断伴随动脉粥样硬化的疾病。

公开(公告)号：KR1020120084466A

公开(公告)日：2012-07-30

申请号：KR1020110005843

申请日：2011-01-20

Applicant: 성균관대학교산학협력단

Inventor： 최규실 ,  서영주 ,  임현철 ,  김영선

IPC: A61K49/18 ,  A61K49/08 ,  A61K49/04 ,  A61P9/10

CPC classification number: A61K49/1809 ,  A61K47/544 ,  A61K49/0004 ,  Y10S514/824

Abstract: PURPOSE: A method for manufacturing an atherosclerotic plaque-specific MR contrast media is provided to enable early diagnosis of atherosclerotic plaque and to control the size of phospholipid nanoparticles. CONSTITUTION: An image material contains atherosclerotic plaque-specific target and MR contrast media conjugated to phospholipid nanoparticles(PLN). The average size of the nanoparticles is fai=5-100 nm. The contrast medium is gadolinium complex or iron oxide nanoparticles. The specific target contains pIL-4 peptide(LQRLFRAFRCLK)and cRGD(RGDfK).

Abstract translation: 目的：提供一种用于制造动脉粥样硬化斑块特异性MR造影剂的方法，以便早期诊断动脉粥样硬化斑块并控制磷脂纳米颗粒的大小。 构成：图像材料含有与磷脂纳米粒子（PLN）缀合的动脉粥样硬化斑块特异性靶标和MR造影剂。 纳米颗粒的平均尺寸为fai = 5-100nm。 造影剂是钆络合物或氧化铁纳米颗粒。 具体目标包含pIL-4肽（LQRLFRAFRCLK）和cRGD（RGDfK）。