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    인유두종 바이러스（ＨＰＶ）유전자를 포함하는자궁경부암의 치료 또는 예방용 ＤＮＡ 백신
    1.
    发明公开
    인유두종 바이러스（ＨＰＶ）유전자를 포함하는자궁경부암의 치료 또는 예방용 ＤＮＡ 백신 失效
    用于治疗或预防包含编码HPV蛋白的基因的癌细胞的DNA疫苗

    公开(公告)号：KR1020080019569A

    公开(公告)日：2008-03-04

    申请号：KR1020070086790

    申请日：2007-08-28

    Applicant: 성균관대학교산학협력단

    Inventor： 양주성 ,  김상우 ,  최정아

    IPC: A61K48/00 ,  A61P35/00

    CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55522 ,  A61K2039/55544 ,  A61K2039/585 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034

    Abstract: A DNA vaccine comprising a gene encoding HPV(human papillomavirus) protein is provided to treat or prevent cervical cancer by effectively inducing humoral immune response and cellular immune response, and increase immune response-inducing efficiency with a relatively small amount of antigen within a short time by injecting the vaccine into dermis by using a tattoo device. A DNA vaccine for preventing and treating cervical cancer comprises an E5 gene of SEQ ID NO:14 and L1 gene of SEQ ID NO:10 and/or L2 gene of SEQ ID NO:12 of HPV selected from HPV genotypes 16, 18, 26, 30, 31, 33, 34, 35, 39, 45, 51, 52, 53, 56, 58, 59, 61, 66, 67, 69, 70 and 73, wherein the E5, L1 and L2 gene are contained in a separate plasmid. A vaccine composition comprises the DNA vaccine and pharmaceutically acceptable carriers or immunoadjuvant selected from LTB(leukotriene B), IL-15(interleukin-15) and GM-CSF(Granulocyte macrophage-colony stimulating factor), and is administered into the dermis or muscle through a tattoo device. A cell line KCLRF-BP-00140 stably expresses the E5 gene of HPV and is used for screening a material, vaccine or drug for diagnosis or treatment of HPV infection.

    Abstract translation: 提供了包含编码HPV（人乳头瘤病毒）蛋白质的基因的DNA疫苗，通过有效诱导体液免疫应答和细胞免疫应答来治疗或预防宫颈癌，并在短时间内用相对少量的抗原增加免疫应答诱导效率 通过使用纹身装置将疫苗注射到真皮中。 用于预防和治疗宫颈癌的DNA疫苗包含选自HPV基因型16,18,26的HPV的SEQ ID NO：14的E5基因和SEQ ID NO：10的L1基因和/或HPV的SEQ ID NO：12的L2基因 ，30,31,33,34,35,39,45,51,52,53,56,58,59,61,66,67,69,70和73，其中E5，L1和L2基因包含在 单独的质粒。 疫苗组合物包含选自LTB（白三烯B），IL-15（白细胞介素-15）和GM-CSF（粒细胞巨噬细胞集落刺激因子）的DNA疫苗和药学上可接受的载体或免疫佐剂，并施用于真皮或肌肉 通过纹身装置。 细胞系KCLRF-BP-00140稳定表达HPV的E5基因，用于筛选用于诊断或治疗HPV感染的材料，疫苗或药物。

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