公开(公告)号：KR100838809B1

公开(公告)日：2008-06-17

申请号：KR1020070043190

申请日：2007-05-03

Applicant: 성균관대학교산학협력단

Inventor： 이두성 ,  카사라다야난다 ,  김봉섭

IPC: C08L23/08 ,  C08L75/04

CPC classification number: A61K9/0024 ,  A61K47/34 ,  C08G18/3293 ,  C08G18/4277 ,  C08G18/428 ,  C08G18/73 ,  C08G2210/00 ,  C08G2230/00

Abstract: A temperature and pH sensitive block copolymer, its preparation method, and a polymer hydrogel type drug delivery vehicle containing the copolymer are provided to improve gel strength in case of injection, thereby inhibiting the initial over release of drug. A temperature and pH sensitive block copolymer comprises a copolymer of a polyethylene-based compound and a biodegradable polymer; and a polyurethane-based oligomer. Preferably the polyethylene-based compound is represented by RO-(CH2-CH2-O)n-H and has a number average molecular weight of 1,000-5,000 g/mol, wherein R is H or a C1-C5 alkyl group; and n is an integer of 11-45. Preferably the biodegradable polymer is a biodegradable aliphatic polyester; and the polyurethane-based oligomer is coupled to the copolymer.

Abstract translation: 提供温度和pH敏感的嵌段共聚物，其制备方法和含有共聚物的聚合物水凝胶型药物递送载体，以改善注射时的凝胶强度，从而抑制药物的初始过度释放。 温度和pH敏感性嵌段共聚物包含聚乙烯基化合物和可生物降解聚合物的共聚物; 和聚氨酯系低聚物。 优选地，聚乙烯类化合物由RO-（CH 2 -CH 2 -O）n -H表示，数均分子量为1,000-5,000g / mol，其中R为H或C 1 -C 5烷基; n为11〜45的整数。 优选地，可生物降解聚合物是可生物降解的脂族聚酯; 并将聚氨酯类低聚物与共聚物偶合。