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    셀레노펜-접합 방향족 화합물, 및 이의 제조 방법
    7.
    发明公开
    셀레노펜-접합 방향족 화합물, 및 이의 제조 방법 有权
    SELENOPHENE-FUSED AROMATIC COMPOUNDS，及其制备方法

    公开(公告)号：KR1020130034638A

    公开(公告)日：2013-04-05

    申请号：KR1020120109215

    申请日：2012-09-28

    Applicant: 세종대학교산학협력단 ,  사회복지법인 삼성생명공익재단

    Inventor： 임동렬 ,  남도현 ,  두베이라스미 ,  이한근

    IPC: C07C391/00 ,  A61K31/095 ,  A61P35/00

    Abstract: PURPOSE: A manufacturing method of a selenophene-fused aromatic compound is provided to obtain various selenophene-fused aromatic compounds at a high yield by varying the kinds of aromatic stating materials. CONSTITUTION: A manufacturing method of a selenophene-fused aromatic compound represented by chemical formula 2 comprises: a step of preparing a diselenide compound represented by chemical formula R^1-CH2-Se-Se-CH2-R^1, a solvent, and a reducing agent; and a step of conducting a reaction by adding an aromatic starting material represented by chemical formula 1 and a base into the reaction mixture. The solvent is selected among dimethylsulfoxide, tetrahydrofuran, CH2Cl2, CH3CN, CH3NO2, CHCl3, ClCH2, CH2Cl, alcohol, an aromatic solvent, and a combination thereof.

    Abstract translation: 目的：提供硒代酚稠合芳香族化合物的制造方法，通过改变芳族化合物的种类，以高收率得到各种硒酚稠合芳香族化合物。 构成：由化学式2表示的硒吩酚稠合芳族化合物的制造方法包括：制备由化学式R 1〜2-Se-Se-CH 2 -R 1表示的二硒化合物的溶剂，溶剂和 还原剂; 以及通过将由化学式1表示的芳族起始原料和碱添加到反应混合物中进行反应的步骤。 溶剂选自二甲基亚砜，四氢呋喃，CH 2 Cl 2，CH 3 CN，CH 3 NO 2，CHCl 3，ClCH 2，CH 2 Cl，醇，芳族溶剂及其组合。

    히스티딘을 포함하는 펩타이드 유사체 및 항바이러스제 또는 항암제로서의 이의 용도
    9.
    发明公开
    히스티딘을 포함하는 펩타이드 유사체 및 항바이러스제 또는 항암제로서의 이의 용도 有权
    肽衍生物，包括抗病毒药物和抗肿瘤剂

    公开(公告)号：KR1020100106791A

    公开(公告)日：2010-10-04

    申请号：KR1020090024979

    申请日：2009-03-24

    Applicant: 주식회사 알로페론 ,  세종대학교산학협력단

    Inventor： 김수인 ,  이왕재 ,  임동렬

    IPC: C07K7/06 ,  A61K38/08 ,  A61P31/12 ,  A61P35/00

    Abstract: PURPOSE: An antiviral or anticancer drug containing peptide analogue with histidine is provided to control NF-kappaB activity and to prevent or treat NF-kappaB-associated diseases. CONSTITUTION: A peptide analogue with histidine is denoted by formula I(X1-His-X2-X3-His-Gly-X4). In formula I, X does not exist or is at least one amino acid or amino acid having alkyl or an aryl group; X2 is an amino acid having beta-amino acid, gamma-amino acid, D-form amino acid, or N-methyl amino acid; X3 does not exist or is an amino acid with gamma-amino acid, D-form amino acid or N-methyl amino acid; X3 does not exist or is an amino acid having L-form amino acid, D-form amino acid, or N-methyl amino acid; and X4 is an amino acid having L-form amino acid, D-form amino acid or N-methyl amino acid. The peptide analogue is Gly-His-β-Ala-Gln-His-Gly-Val. A composition for treating a NF-kappaB-associated disease contains NF-kappaB activity-regulating material having the peptide analogue and hydrate or salt thereof as an active ingredient.

    Abstract translation: 目的：提供含有组氨酸的肽类似物的抗病毒或抗癌药物以控制NF-κB活性并预防或治疗NF-κB相关疾病。 构成：具有组氨酸的肽类似物由式I（X1-His-X2-X3-His-Gly-X4）表示。 在式I中，X不存在或至少一个具有烷基或芳基的氨基酸或氨基酸; X2是具有β-氨基酸，γ-氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸; X3不存在或是具有γ-氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸; X3不存在或是具有L-型氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸; X4是具有L-型氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸。 肽类似物是Gly-His-β-Ala-Gln-His-Gly-Val。 用于治疗NF-κB相关疾病的组合物含有具有肽类似物和水合物或其盐作为活性成分的NF-κB活性调节材料。

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