公开(公告)号：KR1020000052670A

公开(公告)日：2000-08-25

申请号：KR1019997003452

申请日：1997-10-31

Applicant: 솔루티아인코포레이티드

Inventor： 왈러,앤드류,스튜아트

IPC: C12P13/20

CPC classification number: C12P13/20

Abstract: PURPOSE: Provide is a highly efficient process for the production of L-aspartic acid using inexpensive starting substrates. CONSTITUTION: A process for production of L-aspartic acid comprises (1) contacting (A) an enzyme-containing material having maleate isomerase activity and aspartase activity, or (B) an enzyme-containing material having maleate isomerase activity and an enzyme-containing material having aspartase activity, with an aqueous substrate solution containing maleic acid and ammonia, and/or mono or di-ammonium maleate, to form L-ammonium aspartate, in a reaction solution, (2) adding the reaction solution to an aqueous solution of maleic acid or maleic anhydride at a controlled rate to crystallize L-aspartic acid in a mother liquor, and (3) recovering the L-aspartic acid from the mother liquor, and (4) optionally recycling the mother liquor as a substrate solution for further reaction with said enzyme containing material of Step 1 and (5) optionally adding alkali such as ammonia to the mother liquor before, during, or after recycle.

Abstract translation: 目的：提供使用廉价起始底物生产L-天冬氨酸的高效方法。 构成：生产L-天冬氨酸的方法包括（1）使（A）具有马来酸异构酶活性和天冬氨酰酶活性的含酶材料接触，或（B）具有马来酸异构酶活性的含酶材料和含酶 具有天冬氨酸活性的材料，含有马来酸和氨的水性底物溶液和/或马来酸单或二铵，以在反应溶液中形成L-天冬氨酸铵，（2）将反应溶液加入到 马来酸或马来酸酐以控制速率在母液中结晶L-天冬氨酸，和（3）从母液中回收L-天冬氨酸，和（4）任选地将母液作为底物溶液再循环进一步 与步骤1和（5）的含酶材料反应，任选地在回收之前，期间或之后向母液中加入碱如氨。