公开(公告)号：KR1020130097960A

公开(公告)日：2013-09-04

申请号：KR1020120019670

申请日：2012-02-27

Applicant: 수원대학교산학협력단

Inventor： 임교빈 ,  유종훈 ,  정인일

IPC: A61K9/16 ,  A61K9/14 ,  A61K47/30 ,  A61K31/7068

CPC classification number: A61K9/1682 ,  A61K9/1647 ,  A61K31/7068

Abstract: PURPOSE: A gemcitabine-containing polyester-based biodegradable polymeric microparticle using a supercritical fluid and a method for preparing the same are provided to obtain the microparticles with improved encapsulation efficiency, stability, and release property of hydrophilic gemcitabine. CONSTITUTION: A method for preparing gemcitabine-encapsulated polymeric microparticles comprises the steps of: dissolving gemcitabine, a polyester-based biodegradable polymer, or a mixture thereof in each solvent and mixing to prepare a mixture solution; contacting the mixture solution with a supercritical fluid by spraying to form gemcitabine-encapsulated polyester-based biodegradable polymeric microparticles; and removing remaining solvents.

Abstract translation: 目的：提供一种使用超临界流体的含有吉西他滨的聚酯类生物降解性聚合物微粒及其制备方法，以获得具有改善的亲水性吉西他滨的包封效率，稳定性和释放性的微粒。 构成：制备吉西他滨包封的聚合物微粒的方法包括以下步骤：将吉西他滨，聚酯基生物降解聚合物或其混合物溶解于各种溶剂中并混合以制备混合溶液; 通过喷雾将混合溶液与超临界流体接触以形成吉西他滨封装的聚酯基生物可降解聚合物微粒; 并除去剩余的溶剂。