公开(公告)号：KR1020110135202A

公开(公告)日：2011-12-16

申请号：KR1020100054976

申请日：2010-06-10

Applicant: 아주대학교산학협력단

Inventor： 김문석 ,  강미란 ,  김이슬 ,  김경해

IPC: C12N5/079 ,  C12N5/0775 ,  C12N5/02 ,  C07K14/50

Abstract: PURPOSE: A method for differentiating muscle-derived stem cells into neural cells using bFGF of high concentration and neural system drugs is provided to obtain cell source for regenerating a central nervous system. CONSTITUTION: A method for differentiating muscle-derived stem cells into neural cells comprises a step of using a material which induces muscle-derived stem cells into neural cells. The material is nervous system drug and bFGF(basic fibroblast growth factor). The muscle-derived stem cells are treated using 10-25ng of bFGF and 0.0625 mM to 4 mM of nervous system drug. The nervous system drug is ethosuximide, carbamazepine, valproic acid, galantamine, levodopa, or donepezil.

Abstract translation: 目的：提供使用高浓度和神经系统药物的bFGF将肌肉干细胞分化成神经细胞的方法，以获得中枢神经系统再生的细胞来源。 构成：将肌肉来源的干细胞分化成神经细胞的方法包括使用诱导肌肉干细胞进入神经细胞的材料的步骤。 该物质是神经系统药物和bFGF（碱性成纤维细胞生长因子）。 使用10-25ng的bFGF和0.0625mM至4mM的神经系统药物治疗肌肉干细胞。 神经系统药物是乙酰亚胺，卡马西平，丙戊酸，加兰他敏，左旋多巴或多奈哌齐。