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公开(公告)号：KR101373661B1
公开(公告)日：2014-03-13
申请号：KR1020120006077
申请日：2012-01-19
Applicant: 아주대학교산학협력단
IPC: C07K1/02 , C07K14/435 , A61K38/17 , A61L27/22
Abstract: 본 발명은 이온성 액체를 이용한 아밀로이드의 제조 방법에 관한 발명으로써,
단백질에 화학식 1로 표시되는 이온성 액체 화합물(1-부틸-3-메틸 이미다졸리움을 양이온으로 기반하는 화합물, 식 중 X는 음이온 화합물을 대표함)을 처리하여 인큐베이션 하는 단계를 포함하는 아밀로이드 제조방법에 관한 발명이다.
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본 발명은 아밀로이드의 생체 재료로서의 활용 및 아밀로이드-연관 퇴행성 신경질환 연구를 위해 상기 방법을 거쳐 아밀로이드 섬유를 제조하는 방법을 제공한다.-
公开(公告)号：KR1020130085140A
公开(公告)日：2013-07-29
申请号：KR1020120006077
申请日：2012-01-19
Applicant: 아주대학교산학협력단
IPC: C07K1/02 , C07K14/435 , A61K38/17 , A61L27/22
Abstract: PURPOSE: A manufacturing method of amyloid using ionic liquid is provided to show that the ionic liquid having the structure of Chemical formula 1 induces and accelerates protein to form amyloid, and to be able to shorten the amyloid manufacture to one week or less. CONSTITUTION: A manufacturing method of amyloid using ionic liquid comprises a step of incubating with treatment of protein with an ionic liquid compound (a compound with 1-butyl-3-methyl imidazolium as cation, in Chemical formula 1, X represents an anionic compound) represented by Chemical formula 1. The cationic compound is selected from the group consisting of bis (trifluoromethylsulfonyl)imide, tetrafluoro borate, hexafluoro phosphate, and methylsulfonate. The incubation is performed for 2-8 days. The protein is any one among hen egg white lysozyme (HEWL), calcium-saturated alpha-lactalbumin, trypsin, and insulin. A composition for biomaterial includes amyloid manufactured by said manufacturing method.
Abstract translation: 目的：提供使用离子液体的淀粉样蛋白的制造方法，以显示具有化学式1结构的离子液体诱导和加速蛋白质形成淀粉样蛋白，并且能够将淀粉样蛋白制造物缩短至一周或更短。 构成：使用离子液体的淀粉样蛋白的制造方法包括用离子液体化合物（与1-丁基-3-甲基咪唑鎓作为阳离子的化合物，化学式1中，X表示阴离子化合物）一起处理蛋白质的步骤， 由化学式1表示。阳离子化合物选自双（三氟甲磺酰基）酰亚胺，四氟硼酸盐，六氟磷酸盐和甲基磺酸盐。 孵育2-8天。 蛋白质是鸡蛋白溶菌酶（HEWL），钙饱和α-乳清蛋白，胰蛋白酶和胰岛素中的任一种。 用于生物材料的组合物包括通过所述制造方法制造的淀粉样蛋白。
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