公开(公告)号：KR100748038B1

公开(公告)日：2007-08-09

申请号：KR1020060097907

申请日：2006-10-09

Applicant: 아주대학교산학협력단

Inventor： 박기동 ,  배진우 ,  최원섭

IPC: A61F2/06 ,  A61L27/14 ,  A61L27/22

Abstract: An artificial vessel for immobilizing bioactive materials is provided to effectively induce a growth of vein endothelial cell by forming a polymer support layer and a biodegradable coating layer. An artificial vessel includes a polymer support layer consisting of biocompatible polymer modified surface by heparin, vein endothelial cell adhesive peptides, and hydrophilic polymer and a biodegradable coating layer formed on the upper surface of the polymer support layer containing biodegradable polymer, heparin, and vein endothelial cell adhesive peptides. The heparin is any one selected from a group consisting of heparin, recombinant heparin, heparin derivative, and heparin analogue.

Abstract translation: 提供用于固定生物活性物质的人造血管以通过形成聚合物支持层和生物可降解涂层来有效诱导静脉内皮细胞的生长。 人造血管包括聚合物支持层，其由肝素生物相容性聚合物改性表面，静脉内皮细胞粘附肽和亲水性聚合物组成，并且在聚合物支持层的上表面上形成的可生物降解涂层包含生物可降解聚合物，肝素和静脉内皮 细胞粘附肽。 肝素是选自肝素，重组肝素，肝素衍生物和肝素类似物中的任一种。