公开(公告)号：KR1020030002213A

公开(公告)日：2003-01-08

申请号：KR1020010038966

申请日：2001-06-30

Applicant: 알앤엘생명과학주식회사

Inventor： 김성훈 ,  강경선 ,  박용호 ,  라정찬 ,  강인철 ,  송호철

IPC: A61K36/284 ,  A61K36/076 ,  A61K36/258 ,  A61P35/04

Abstract: PURPOSE: A composition containing medicinal plants such as Atractylodis Rhizoma Alba, Hoelen, Ginseng Radix, Glycyrrhizae Radix or the like is provided which has an excellent cancer and cancer metastasis suppressing effect while having angiogenesis inhibiting activity. CONSTITUTION: The composition comprises 4 to 14% by weight of Atractylodis Rhizoma Alba, 4 to 14% by weight of Hoelen, 4 to 14% by weight of Ginseng Radix, 2 to 12% by weight of Glycyrrhizae Radix, 2 to 12% by weight of Dioscoreae Rhizoma, 2 to 12% by weight of Dolichoris Semen, 2 to 12% by weight of Nelumbinis Semem, 2 to 12% by weight of Coicis Semen, 2 to 12% by weight of Amomi Semen, 2 to 12% by weight of Platycodi Radix, 2 to 12% by weight of Oldenlandiae diffusae Herba, 4 to 14% by weight of Herba houttuyniae and 4 to 14% by weight of Agrimoniae Herba.

Abstract translation: 目的：提供含有药用植物如Atractylodis Rhizoma Alba，Hoelen，人参，甘草等的组合物，其具有优异的癌症和癌症转移抑制作用，同时具有血管生成抑制活性。 组成：组合物包含4至14重量％的白术，4至14重量％的Hoelen，4至14重量％的人参，2至12重量％的甘草，2至12重量％的甘草 Dioscoreae Rhizoma的重量，Diichreis Semen的2至12重量％，Nelumbinis Semem的2至12重量％，Coicis Semen的2至12重量％，Amomi Semen的2至12重量％，Amomi Semen的2至12重量％ 桔梗的重量，2至12重量％的野草兰草，4至14重量％的草药和4至14重量％的草地草。

公开(公告)号：KR1020020084875A

公开(公告)日：2002-11-13

申请号：KR1020010024275

申请日：2001-05-04

Applicant: 알앤엘생명과학주식회사 ,  강경선

Inventor： 강경선 ,  이영순 ,  김성훈

IPC: A61K36/44 ,  A61P5/30

Abstract: PURPOSE: A composition for hormone replacement therapy containing a natural extract such as persimmon leaves extract which produces an estrogen-like material is provided which can be used as a health food product or a therapeutic agent for hormone replacement therapy of a menopausal woman. CONSTITUTION: Persimmon leaves are extracted 1 to 20 times with water, extracted at 60 to 100deg.C for 1 to 6hr, filtered or centrifuged and then concentrated under reduced pressure, or they are extracted 5 to 20 times with lower alcohol, preferably 60 to 80% ethanol at 60 to 100deg.C while flowing backward for 1 to 6hr, filtered and then concentrated. For example, 100g persimmon leaves are added to 2L ethanol, flowed backward while heating at 90deg.C for 3hr, filtered and then concentrated under reduced pressure. Thereafter, the extract is applied to Saccharomyces cerevisiae to identify estrogenicity.

Abstract translation: 目的：提供一种用于激素替代疗法的组合物，其含有天然提取物如柿子叶提取物，其产生雌激素样物质，其可用作绝经妇女的保健食品或激素替代疗法的治疗剂。 构成：将柿叶用水提取1〜20次，在60〜100℃下提取1〜6小时，过滤或离心，减压浓缩，或用低级醇提取5〜20次，优选60〜 80％乙醇，60至100℃，同时向后流动1至6小时，过滤并浓缩。 例如，将100g柿子叶加入到2L乙醇中，在90℃加热3小时后向后流动，过滤，然后减压浓缩。 此后，将提取物施用于酿酒酵母以鉴定雌激素。

公开(公告)号：KR1020020084874A

公开(公告)日：2002-11-13

申请号：KR1020010024274

申请日：2001-05-04

Applicant: 알앤엘생명과학주식회사 ,  강경선

Inventor： 강경선 ,  이영순 ,  김성훈

IPC: A61K36/49 ,  A61P5/30

Abstract: PURPOSE: A composition containing an extract of Castanea crenata Sieb. et Zucc. producing a human estrogen receptor-binding material as an effective component is provided. Because the composition has androgenicity, it can be used as a prophylactic and therapeutic agent for androgen deficiency and prostate cancer as well as a health food composition. CONSTITUTION: The pharmaceutical composition contains 0.1 to 50% by weight of a Castanea crenata extract, in which the extract is administered at daily doses of 0.001 to 100mg/kg through an oral, transdermal, subcutaneous, intravenous or muscular pathway. For example, 100g Castanea crenata Sieb. et Zucc. is added to 2L ethanol, flowed backward while heating at 90deg.C for 3hr, filtered and then concentrated under reduced pressure.

Abstract translation: 目的：一种含有Castanea crenata Sieb提取物的组合物。 等Zucc。 提供了作为有效成分的人雌激素受体结合材料。 因为该组合物具有雄激素性，所以可以用作雄激素缺乏和前列腺癌的预防和治疗剂以及保健食品组合物。 构成：药物组合物含有0.1至50重量％的卡氏炭疽提取物，其中通过口服，透皮，皮下，静脉内或肌肉途径以0.001至100mg / kg的日剂量施用提取物。 例如，100g Castanea crenata Sieb。 等Zucc。 加入到2L乙醇中，在90℃加热3小时，向后流动，过滤，然后减压浓缩。

公开(公告)号：KR1020030002214A

公开(公告)日：2003-01-08

申请号：KR1020010038967

申请日：2001-06-30

Applicant: 알앤엘생명과학주식회사

Inventor： 김성훈 ,  강경선 ,  박용호 ,  라정찬 ,  강인철 ,  노석선

IPC: A61K36/232 ,  A61K36/21 ,  A61K36/804 ,  A61P25/28

Abstract: PURPOSE: A composition containing an extract of medicinal plants which has excellent effects on reduction of an ischemic area of the brain, or edema is provided which can be used in the prophylaxis and treatment of a brain disease such as cerebral apoplexy, dementia or the like. CONSTITUTION: A mixture of 3.57 to 16% by weight of Angelicae Gigantis Radix, 3.57 to 16% by weight of Achyranthis bidentatae Radix, 3.57 to 16% by weight of Rehmanniae Radix, 3.57 to 10.7% by weight of Persicae Semen, 3.57 to 9% by weight of Aurantii Fructus, 3.57 to 9% by weight of Paeoniae Radix rubra, 1.78 to 5.35% by weight of Bupleuri Radix, 1.78 to 5.35% by weight of Glycyrrhizae Radix, 2.68 to 7.14% by weight of Platycodi Radix, 2.68 to 7.14% by weight of Cnidii Rhizoma, 3.57 to 9% by weight of Lumbricus and 3.57 to 9% by weight of Panax wangianus Sun is extracted in a solvent selected from the group consisting of water, hexane, butanol, ether and ethylacetate.

Abstract translation: 目的：提供含有对脑缺血区域的减少具有优异效果的药用植物提取物或水肿的组合物，其可用于预防和治疗脑疾病如脑中风，痴呆等 。 构成：将3.57至16重量％的当归，3.57至16重量％的Achyranthis bidentatae大黄，3.57至16重量％的地黄，3.57至10.7重量％的Persicae精液，3.57至9 枸杞子的重量百分比为3.57〜9重量％，白胡椒为1.78〜5.35重量％，甘草为1.78〜5.35重量％，扁桃菊为2.68〜7.14重量％，2.68〜 在选自水，己烷，丁醇，乙醚和乙酸乙酯的溶剂中提取7.14重量％的Cnidii Rhizoma，3.57至9重量％的Lumbricus和3.57至9重量％的Panax wangianus Sun。

公开(公告)号：KR1020020084873A

公开(公告)日：2002-11-13

申请号：KR1020010024273

申请日：2001-05-04

Applicant: 알앤엘생명과학주식회사 ,  강경선

Inventor： 강경선 ,  이영순 ,  김성훈

IPC: A61K36/185 ,  A61P5/30

Abstract: PURPOSE: A composition containing an Eugenia caryophyllata Thunb. extract is provided which exhibits steroid human estrogen receptor-binding activity such as estrogen or androgen as an effective component. Because the composition has the same effect as administration of estrogen, it can be used as a prophylactic and therapeutic agent for osteoporosis or prostate cancer. CONSTITUTION: The pharmaceutical composition containing 0.1 to 50% by weight of an Eugenia caryophyllata Thunb. extract is administered through an oral, transdermal, subcutaneous, intravenous or muscular pathway and the effective amount of the extract for treatment of hormone replacement therapy is in the range of 0.001 to 100mg/kg per a day. Eugenia caryophyllata Thunb. is extracted 1 to 20 times with water or 5 to 20 times with low alcohol, filtered or centrifuged and then concentrated.

Abstract translation: 目的：含有Eugenia caryophyllata Thunb的组合物。 提供了显示类固醇人雌激素受体结合活性的提取物，例如雌激素或雄激素作为有效成分。 由于该组合物与施用雌激素具有相同的效果，因此可以用作骨质疏松症或前列腺癌的预防和治疗剂。 构成：含有0.1〜50重量％的金丝桃（Eugenia caryophyllata Thunb）的药物组合物。 提取物通过口服，透皮，皮下，静脉内或肌肉途径施用，并且用于治疗激素替代疗法的提取物的有效量在每天0.001至100mg / kg的范围内。 金丝桃（Eugenia caryophyllata Thunb） 用水提取1〜20次，用低醇提取5〜20次，过滤或离心，然后浓缩。

公开(公告)号：KR1020020084871A

公开(公告)日：2002-11-13

申请号：KR1020010024271

申请日：2001-05-04

Applicant: 알앤엘생명과학주식회사 ,  강경선

Inventor： 강경선 ,  이영순 ,  김성훈

IPC: A61K36/482 ,  A61P5/30

Abstract: PURPOSE: A composition containing a Cassia tora L. extract which is estrogen-like material and effective in hormone activity is provided. Therefore, the composition can be used as a therapeutic agent or health food for hormone replacement therapy of a menopausal woman and orally or parenterally administered for a clinical application use. CONSTITUTION: Cassia tora L. is extracted 1 to 20 times with water or 5 to 20 times with low alcohol selected from the group consisting of methanol or a methanol aqueous solution, ethanol or an ethanol aqueous solution, normal propanol, iso-propanol, normal butanol and a mixture thereof at 60 to 100deg.C for 1 to 6hr, filtered or centrifuged and then concentrated under reduced pressure. An effective amount of the extract for treatment of hormone replacement therapy is in the range of 0.001 to 100mg/kg per a day and a food product and beverage contains 0.1 to 50% by weight of the extract.

Abstract translation: 目的：提供含有雌激素样物质，有效激素活性的桂皮提取物的组合物。 因此，该组合物可以用作绝经妇女的激素替代疗法的治疗剂或保健食品，并且用于临床应用的口服或肠胃外给药。 构成：将决明子用水或甲醇或甲醇水溶液，乙醇或乙醇水溶液，正丙醇，异丙醇，正丙醇，正丙醇，异丙醇， 丁醇及其混合物在60至100℃下反应1至6小时，过滤或离心，然后减压浓缩。 用于治疗激素替代疗法的提取物的有效量在每天0.001至100mg / kg的范围内，食品和饮料含有0.1至50重量％的提取物。

公开(公告)号：KR1020020084877A

公开(公告)日：2002-11-13

申请号：KR1020010024278

申请日：2001-05-04

Applicant: 알앤엘생명과학주식회사 ,  강경선

Inventor： 강경선 ,  이영순 ,  김성훈

IPC: A61K36/481 ,  A61P5/30

Abstract: PURPOSE: A composition containing an Astragalus membranaceus B. extract as an effective component which is estrogen-like material and effective in hormone activity is provided. Therefore, the composition is useful as a prophylactic and therapeutic agent for treatment of osteoporosis or prostate cancer as well as a health food. CONSTITUTION: The pharmaceutical composition contains 0.1 to 50% by weight of an Astragalus membranaceus Bunge extract extracted with water or low alcohol. The extract is administered at a daily dose of 0.001 to 100mg/kg through an oral, transdermal, subcutaneous, intravenous or muscular pathway. The composition contains a generally used diluent or excipient such as a filler, bulking agent, binding agent, wetting agent, disintegrating agent and surfactant, together with the extract.

Abstract translation: 目的：提供含有黄芪B.提取物作为雌激素样物质并有效激素活性的有效成分的组合物。 因此，该组合物可用作治疗骨质疏松症或前列腺癌的预防和治疗剂以及保健食品。 构成：药物组合物含有0.1〜50重量％的用水或低醇萃取的黄芪提取物。 提取物通过口服，透皮，皮下，静脉内或肌肉途径以0.001至100mg / kg的日剂量施用。 组合物与提取物一起含有通常使用的稀释剂或赋形剂，例如填料，填充剂，粘合剂，润湿剂，崩解剂和表面活性剂。

公开(公告)号：KR1020020084876A

公开(公告)日：2002-11-13

申请号：KR1020010024276

申请日：2001-05-04

Applicant: 알앤엘생명과학주식회사 ,  강경선

Inventor： 강경선 ,  이영순 ,  김성훈

IPC: A61K36/185 ,  A61P5/30

Abstract: PURPOSE: A composition containing an extract which exhibits human estrogen receptor-binding activity and is extracted from Malva verticillata L. as a main component is provided. Because the extract is an estrogen-like material and effective in hormone activity, it can be used as a pharmaceutical or health food composition for hormone replacement therapy of a menopausal woman as well as androgen deficiency and prostate cancer. CONSTITUTION: A Malva verticillata L. extract is administered in an amount of 0.001 to 100mg/kg per a day for hormone replacement therapy of a menopausal woman and a health food composition also contains 0.1 to 50% by weight of the extract. The composition can be used for oral or parenteral administration for a clinical application use and formulated into general pharmaceutical forms. The Malva verticillata L. extract is prepared by extracting 1 to 20 times with water or 5 to 20 times with lower alcohol, filtered or centrifuged and then concentrated under reduced pressure.

Abstract translation: 目的：提供一种含有表现出人雌激素受体结合活性并以马鞭草为主要成分提取的提取物的组合物。 因为提取物是一种雌激素样物质，对激素活性有效，因此可用作绝经妇女激素替代疗法以及雄激素缺乏症和前列腺癌的药物或保健食品组合物。 构成：对绝经妇女进行激素替代疗法，马尔维（Vert。）提取物每天以0.001至100mg / kg的量施用，并且保健食品组合物还含有0.1至50重量％的提取物。 该组合物可用于临床应用用途的口服或肠胃外给药并配制成一般药物形式。 通过用水提取1〜20次或用低级醇提取5〜20倍制备马鞭草提取物，过滤或离心，然后减压浓缩。

公开(公告)号：KR1020020084872A

公开(公告)日：2002-11-13

申请号：KR1020010024272

申请日：2001-05-04

Applicant: 알앤엘생명과학주식회사 ,  강경선

Inventor： 강경선 ,  이영순 ,  김성훈

IPC: A61K36/9062 ,  A61P5/30

Abstract: PURPOSE: A composition containing an Alpinia katsumadai Hayata extract as an effective component is provided. The composition can be used as a pharmaceutical composition for hormone replacement therapy of a menopausal woman because it exhibits human estrogen receptor-binding activity. CONSTITUTION: The pharmaceutical composition for treatment of hormone replacement therapy contains 0.1 to 50% by weight of an Alpinia katsumadai Hayata extract and the extract is orally administered at a daily dose of 0.001 to 100mg/kg. The Alpinia katsumadai Hayata extract is prepared by extracting with water or lower alcohol selected from methanol, ethanol, normal propanol, iso-propanol, normal butanol and a mixture thereof at 60 to 100deg.C, filtering or centrifuging and then concentrating under reduced pressure.

Abstract translation: 目的：提供一种含有山楂提取物作为有效成分的组合物。 该组合物可用作绝经妇女的激素替代疗法的药物组合物，因为它表现出人雌激素受体结合活性。 构成：用于治疗激素替代疗法的药物组合物含有0.1〜50重量％的山楂提取物，并以0.001〜100mg / kg的日剂量口服给药提取物。 通过在60至100℃下，将选自甲醇，乙醇，正丙醇，异丙醇，正丁醇及其混合物的水或低级醇萃取，过滤或离心，然后减压浓缩，制备高山ata杷提取物。