公开(公告)号：KR1020130142625A

公开(公告)日：2013-12-30

申请号：KR1020120065990

申请日：2012-06-20

Applicant: 연세대학교 산학협력단

Inventor： 정진현 ,  최용성 ,  김윤정 ,  임지순 ,  이인수

IPC: C12P41/00 ,  C12N11/14 ,  C12N9/20 ,  C12M1/40

CPC classification number: C12P41/00 ,  C12N9/20 ,  C12N11/10 ,  C12P5/02 ,  C12P7/62 ,  C12P17/04

Abstract: The present invention relates to a dividing method of a racemic compound which comprises the following steps: producing enzyme immobilized alginate beads using a microflow reactor; and making the alginate beads react with a racemic compound inside a continuous flow reactor. By immobilizing enzymes to microbeads, the usage amount of the enzymes is reduced, the reaction efficiency is increased, and the usage amount of solvents is reduced by removing a post-processing step of separating the enzymes after the reaction. A continuous reaction process of the enzymes using the microflow reactor shows high conversion rate of carbon dioxide compared to a batch-based reaction.

Abstract translation: 本发明涉及外消旋化合物的分解方法，其包括以下步骤：使用微流反应器生产酶固定的藻酸盐珠; 并使藻酸盐珠粒与连续流动反应器内的外消旋化合物反应。 通过将酶固定在微珠上，酶的使用量降低，反应效率提高，通过除去反应后的酶分离后处理步骤，可以降低溶剂的使用量。 使用微流反应器的酶的连续反应过程与基于批次的反应相比显示出高的二氧化碳转化率。