中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

9 records (took 0.021 seconds)

    신규한 비펩타이드성 화합물, 이의 제조방법 및 이를포함하는 약학 조성물
    6.
    发明公开
    신규한 비펩타이드성 화합물, 이의 제조방법 및 이를포함하는 약학 조성물 有权
    新的非肽化合物，其制备方法和包含其的药物组合物

    公开(公告)号：KR1020070115768A

    公开(公告)日：2007-12-06

    申请号：KR1020070053659

    申请日：2007-06-01

    Applicant: 이화여자대학교 산학협력단

    Inventor： 박혜영 ,  나흥식 ,  감유림 ,  이희경 ,  백승근

    IPC: C07D295/104 ,  C07D243/08

    CPC classification number: C07D295/185

    Abstract: Non-peptide compounds are provided to inhibit activity of bradykinin, chronic neuropathic pain and inflammatory pain, so that they are useful for prevention and treatment of disease caused by bradykinin such as pain. The non-peptide compounds represented by the formula(1) or pharmaceutically acceptable salts thereof are provided, wherein R1 and R2 are each independently hydrogen; C1-C4 alkyl; C1-C4 alkoxy; C3-C10 cycloalkyl; C6-C20 aryl and C5-C20 heteroaryl which are optionally substituted by at least one substituent selected from group consisting of C1-C4 alkyl, C1-C4 alkoxy or halogen; C1-C4 alkyl substituted by C6-C20 aryl which is optionally substituted by at least one substituent selected from group consisting of C1-C4 alkyl, C1-C4 alkoxy or halogen; and C1-C4 alkyl substituted by C5-C20 hetero aryl which is optionally substituted by at least one substituent selected from group consisting of C1-C4 alkyl, C1-C4 alkoxy or halogen; X is C1-C4 alkylenyl optionally substituted by C1-C4 alkyl, C1-C4 alkoxy or halogen; C2-C6 alkenylenyl optionally substituted by C1-C4 alkyl, C1-C4 alkoxy or halogen, -CH2YCH2- or -CH2CH2Y-; Y is O, S or NR3; R3 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, halogen or -COO-C1-C4 alkyl; Z and Z' are each independently hydrogen, hydroxy or halogen; and n is an integer from 1 to 3.

    Abstract translation: 提供非肽化合物以抑制缓激肽，慢性神经性疼痛和炎性疼痛的活性，从而可用于预防和治疗由缓激肽引起的疾病如疼痛。 提供由式（1）表示的非肽化合物或其药学上可接受的盐，其中R 1和R 2各自独立地为氢; C 1 -C 4烷基; C1-C4烷氧基; C3-C10环烷基; 任选被至少一个选自C 1 -C 4烷基，C 1 -C 4烷氧基或卤素的取代基取代的C 6 -C 20芳基和C 5 -C 20杂芳基; 被任选被至少一个选自C 1 -C 4烷基，C 1 -C 4烷氧基或卤素的取代基取代的C 6 -C 20芳基取代的C 1 -C 4烷基; 和被任选被至少一个选自C 1 -C 4烷基，C 1 -C 4烷氧基或卤素的取代基取代的C 5 -C 20杂芳基取代的C 1 -C 4烷基; X是任选被C 1 -C 4烷基，C 1 -C 4烷氧基或卤素取代的C 1 -C 4亚烷基; 任选被C 1 -C 4烷基，C 1 -C 4烷氧基或卤素取代的C 2 -C 6烯基，-CH 2 YCH 2 - 或-CH 2 CH 2 Y-; Y为O，S或NR 3; R3是氢，C1-C4烷基，C1-C4烷氧基，卤素或-COO-C1-C4烷基; Z和Z'各自独立地为氢，羟基或卤素; n为1〜3的整数。

    신규한 화합물, 이의 제조방법 및 이를 포함하는 통증억제용 조성물
    7.
    发明公开
    신규한 화합물, 이의 제조방법 및 이를 포함하는 통증억제용 조성물 失效
    新化合物，其制备方法以及包含其抑制性疼痛的组合物

    公开(公告)号：KR1020090028239A

    公开(公告)日：2009-03-18

    申请号：KR1020070093694

    申请日：2007-09-14

    Applicant: 이화여자대학교 산학협력단

    Inventor： 박혜영 ,  나흥식 ,  박명호 ,  감유림 ,  백승근

    IPC: C07D295/104 ,  A61K31/495 ,  A61P29/00

    CPC classification number: C07D295/104 ,  C07D295/10

    Abstract: A compound is provided to suppress effectively chronic neuropathic pain and inflammatory pain by suppressing T-type calcium channel activity. A compound is indicated as a chemical formula 1. In the chemical formula 1: R1 is hydrogen; cycloalkyl of CH2-C3~C10; benzyl substituted or non-substituted to one or more radicals selected from a group consisting of linear or branched alkyl of C1~C10, alkoxy of C1~C4, halogen, nitro and N(CH3)2. In the chemical formula 1: R2 is NR5R6; R3 and R4 are aryl of C6~C20 or aryl of C6~C20 substituted to halogen; R5 and R6 are hydrogen, p- tolyloxy or C6~C20 of aryl; n is integer of 1 to 5.

    Abstract translation: 提供化合物以通过抑制T型钙通道活性来有效抑制慢性神经性疼痛和炎性疼痛。 化合物表示为化学式1.在化学式1中：R 1是氢; CH2-C3〜C10的环烷基; 苄基取代或未取代至一个或多个选自C1〜C10的直链或支链烷基，C1〜C4烷氧基，卤素，硝基和N（CH3）2）的基团。 化学式1：R2为NR5R6; R3和R4是C6〜C20的芳基或C6〜C20被卤素取代的芳基; R5和R6是芳基的氢，对甲苯氧基或C6〜C20; n为1〜5的整数。

    통증 억제용 조성물
    9.
    发明公开
    통증 억제용 조성물 有权
    减轻疼痛的成分

    公开(公告)号：KR1020080094010A

    公开(公告)日：2008-10-22

    申请号：KR1020087018507

    申请日：2006-03-17

    Applicant: 이화여자대학교 산학협력단

    Inventor： 박혜영 ,  나흥식 ,  백승근 ,  임은정 ,  감유림

    IPC: A61K31/496 ,  A61P29/00

    CPC classification number: A61K31/496

    Abstract: A composition for relieving pain is provided to relieve pain, particularly neuropathic pain and inflammatory pain and be useful for preventing or treating pain not controlled by previous analgesics. A composition for relieving pain such as neuropathic pain comprises a compound represented by a formula(1) or a pharmaceutically acceptable salt thereof as an effective ingredient, wherein R^1 is isopropyl, benzyl, 4-methylbenzyl, 4-methoxybenzyl, l-methyl-3-phenyl propyl, 3,4,5-trimethoxybenzyl, 2-(4-(4-chlorophenyl)thiazole), 3-(5-t-butylisoxazole), 2-(4-(4-bromophenyl)thiazole), cyclohexyl, 5-(3-methylisoxazole) or 3,4-dibenzyloxypenethyl; R^2 is H or R^3CO; and R^3 is methyl, phenyl, benzyl, naphthyl(C10H7) or C10H7CH2. A method for relieving pain comprises a step of administering the compound of the formula(I) or the pharmaceutically acceptable salt thereof to a subject.

    Abstract translation: 提供减轻疼痛的组合物以减轻疼痛，特别是神经性疼痛和炎症性疼痛，并且可用于预防或治疗以前的镇痛药不能控制的疼痛。 用于缓解疼痛的组合物，例如神经性疼痛包括由式（1）表示的化合物或其药学上可接受的盐作为有效成分，其中R 1是异丙基，苄基，4-甲基苄基，4-甲氧基苄基，1-甲基 （4-（4-氯苯基）噻唑），3-（5-叔丁基异恶唑），2-（4-（4-溴苯基）噻唑）， 环己基，5-（3-甲基异恶唑）或3,4-二苄氧基乙基乙基; R 2是H或R 3，3CO; R 3是甲基，苯基，苄基，萘基（C 10 H 7）或C 10 H 7 CH 2。 减轻疼痛的方法包括向受试者施用式（I）化合物或其药学上可接受的盐的步骤。

Patent Agency Ranking