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公开(公告)号：KR1020110023190A
公开(公告)日：2011-03-08
申请号：KR1020090080865
申请日：2009-08-31
Applicant: 일동홀딩스(주)
IPC: C07D487/12 , C07D487/14 , C07D233/70
Abstract: PURPOSE: A novel peptide deformylase inhibitor compound is provided to be used as a therapeutic agent for respiratory diseases and a therapeutic agent for respiratory diseases. CONSTITUTION: A novel peptide deformylase inhibitor compound is denoted by chemical formula I. The compound of chemical formula I and pharmaceutically acceptable salt thereof are prepared by reacting a compound of chemical formula III with a compound of chemical formula IVa or IVb or salt thereof. The reaction is performed under the presence of tetrahydrofuran, dichloromethane, N,N-dimethyl formaldehyde. An antibacterial composition contains therapeutically effective amount of novel peptide deformylase inhibitor compound or salt thereof and pharmaceutically acceptable carrier.
Abstract translation: 目的：提供一种新的肽去甲酰化酶抑制剂化合物，用作呼吸系统疾病的治疗剂和呼吸系统疾病的治疗剂。 构成：化学式I表示新的肽失活酶抑制剂化合物。化学式I化合物及其药学上可接受的盐通过化学式III化合物与化学式IVa或IVb化合物或其盐反应制备。 反应在四氢呋喃，二氯甲烷，N，N-二甲基甲醛存在下进行。 抗菌组合物含有治疗有效量的新型肽失活酶抑制剂化合物或其盐和药学上可接受的载体。
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Patent Agency Ranking
公开(公告)号：KR1020140052306A
公开(公告)日：2014-05-07
申请号：KR1020120118279
申请日：2012-10-24
Applicant: 일동홀딩스(주)
IPC: C07D207/18 , C07D207/14 , A61K31/40 , A61P31/04
Abstract: The present invention relates to a novel peptide deformylase (PDF) inhibitor having an excellent antibacterial activity or a pharmaceutically acceptable salt thereof, a method for manufacturing the same, and a pharmaceutical composition comprising the same as an active ingredient.
Abstract translation: 本发明涉及具有优异的抗菌活性的新型肽脱甲酰基酶（PDF）抑制剂或其药学上可接受的盐，其制备方法和包含该肽的活性成分的药物组合物。
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公开(公告)号：KR101462851B1
公开(公告)日：2014-11-18
申请号：KR1020120118279
申请日：2012-10-24
Applicant: 일동홀딩스(주)
IPC: C07D207/18 , C07D207/14 , A61K31/40 , A61P31/04
Abstract: 본 발명은 우수한 항균활성을 가지는 신규 펩티드 데포르밀라제(PDF, peptide deformylase) 저해제 또는 약제학적으로 허용 가능한 염, 이의 제조 방법 및 이를 유효 성분으로 포함하는 약제학적 조성물에 관한 것이다.
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公开(公告)号：KR101447641B1
公开(公告)日：2014-10-13
申请号：KR1020120095999
申请日：2012-08-31
Applicant: 일동홀딩스(주)
IPC: C07D401/04 , C07D413/04 , A61K31/4439 , A61P31/04
Abstract: 본 발명은 우수한 항균활성을 가지는 신규 펩티드 데포르밀라제(PDF, peptide deformylase) 저해제 또는 약제학적으로 허용 가능한 염, 이의 제조 방법 및 이를 유효 성분으로 포함하는 약제학적 조성물에 관한 것이다.
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公开(公告)号：KR1020140028820A
公开(公告)日：2014-03-10
申请号：KR1020120095999
申请日：2012-08-31
Applicant: 일동홀딩스(주)
IPC: C07D401/04 , C07D413/04 , A61K31/4439 , A61P31/04
Abstract: The present invention relates to a novel peptide deformylase (PDF) inhibitor having an outstanding antifungal activity, a pharmaceutically acceptable salt thereof, a manufacturing method of the same, or a pharmaceutical composition comprising the same as an active ingredient.
Abstract translation: 本发明涉及一种具有优异抗真菌活性的新型肽脱甲酰基酶（PDF）抑制剂，其药学上可接受的盐，其制备方法或包含其的活性成分的药物组合物。
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公开(公告)号：KR101184115B1
公开(公告)日：2012-09-18
申请号：KR1020090080865
申请日：2009-08-31
Applicant: 일동홀딩스(주)
IPC: C07D487/12 , C07D487/14 , C07D233/70
Abstract: 본 발명은 우수한 항균활성을 가지는 신규 펩티드 데포르밀라제 (PDF, peptide deformylase) 저해제 또는 약제학적으로 허용 가능한 염, 이의 제조 방법 및 이를 유효 성분으로 포함하는 약제학적 조성물에 관한 것이다.
펩티드 데포르밀라제 (PDF, peptide deformylase), 항균활성, N-포르밀 히드록실아민
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