公开(公告)号：KR100703607B1

公开(公告)日：2007-04-06

申请号：KR1020050118817

申请日：2005-12-07

Applicant: 재단법인대구경북과학기술원 ,  영남대학교 산학협력단

Inventor： 이성준 ,  류원석 ,  강진규 ,  도석주

IPC: D01F6/14 ,  D01D5/00 ,  D04H1/4309 ,  B82Y40/00

公开(公告)号：KR100835898B1

公开(公告)日：2008-06-09

申请号：KR1020060134580

申请日：2006-12-27

Applicant: 재단법인대구경북과학기술원

Inventor： 이세근 ,  이성준 ,  도석주 ,  김참 ,  김호영 ,  류원석

IPC: C08F18/08 ,  C08J3/02

CPC classification number: C08F16/06 ,  C08F4/08 ,  C08F8/12 ,  C08J3/02

Abstract: Polyvinylalcohol hydrogel particles are provided to be amorphous irrespective of the degree of hydrolysis, to ensure relatively low specific gravity and increased surface unevenness, and to exhibit improved dispersibility in a contrast medium when the particles are used as an embolizing agent. Polyvinylalcohol hydrogel particles are prepared by dispersing poly(vinyl acetate) microspheres in an aqueous acid solution. The aqueous acid solution comprises 0.1-3 M of hydrochloric acid, 0.1-500 ml of alcohol, and 0.1-300 g of an inorganic salt, based on the aqueous acid solution 1L. The polyvinylalcohol hydrogel particle has an uneven surface. The alcohol is methanol or ethanol. The inorganic salt is sodium sulfate or sodium sulfite.

Abstract translation: 提供聚乙烯醇水凝胶颗粒为无定形程度的水解，以确保相对低的比重和增加的表面不均匀性，并且当该颗粒用作栓塞剂时，在造影剂中表现出改进的分散性。 通过将聚（乙酸乙烯酯）微球分散在酸性水溶液中制备聚乙烯醇水凝胶颗粒。 酸水溶液包含0.1-3M盐酸，0.1-500ml醇和0.1-300g无水盐，基于1L酸水溶液。 聚乙烯醇水凝胶颗粒具有不均匀的表面。 醇是甲醇或乙醇。 无机盐是硫酸钠或亚硫酸钠。

公开(公告)号：KR1020080060463A

公开(公告)日：2008-07-02

申请号：KR1020060134578

申请日：2006-12-27

Applicant: 재단법인대구경북과학기술원

Inventor： 이세근 ,  이성준 ,  도석주 ,  김참 ,  김호영 ,  류원석

IPC: A61K31/74 ,  A61K31/78 ,  A61P9/00

CPC classification number: A61K31/765

Abstract: A preparation method of X-ray opaque embolic material is provided to prevent problems caused by in vivo resorption of liquid contrast medium, measure the quantitative blood flow and analyze the occlusion degree of blood vessel. A X-ray opaque embolic material is prepared by dipping a polymer particle in iodine or potassium iodide solution to form an iodine complex having X-ray opaque properties, wherein the polymer is a spherical PVAc(polyvinyl acetate) microparticle of which surface is modified by PVA(polyvinyl alcohol) and has the particle size of 100 nm-3000 mum, wherein the iodine complex is formed on both of a core and a surface of the polymer microparticles.

Abstract translation: 提供X射线不透明栓塞材料的制备方法，以防止液体造影剂体内吸收引起的问题，测量血液的定量血液并分析血管闭塞程度。 通过将聚合物颗粒浸渍在碘或碘化钾溶液中以形成具有X射线不透明性质的碘络合物来制备X射线不透明栓塞材料，其中聚合物是球形PVAc（聚乙酸乙烯酯）微粒，其表面被 PVA（聚乙烯醇），其粒径为100nm〜3000μm，其中碘络合物形成在聚合物微粒的芯和表面上。

公开(公告)号：KR100762255B1

公开(公告)日：2007-10-04

申请号：KR1020060134579

申请日：2006-12-27

Applicant: 재단법인대구경북과학기술원 ,  영남대학교 산학협력단

Inventor： 이성준 ,  이세근 ,  김호영 ,  도석주 ,  김참 ,  류원석

IPC: D01D5/00 ,  B82Y40/00

CPC classification number: D01D5/003 ,  B82Y40/00 ,  D01F6/62

Abstract: A method for manufacturing nanofiber is provided to produce a nonwoven fabric formed of continued nanofiber without beads, by mixing and spinning polymers having the same molecular structure and different molecular weights. A spinning solution is formed by mixing and dissolving a plurality of polymers in a solvent, wherein the polymers have the same molecular structure and different molecular weights(S110). The spinning solution is electro-spun and enriched to prepare nanofiber(S120). Each of the polymers has a weight percents of at least 10%, based on the total weight of the polymers. The plurality of polymers are polycaprolactone substances having different molecular weights.

Abstract translation: 提供一种制造纳米纤维的方法，通过混合并纺丝具有相同分子结构和不同分子量的聚合物，制造由连续纳米纤维形成的无珠的无纺织物。 通过将多种聚合物混合并溶解在溶剂中形成纺丝溶液，其中聚合物具有相同的分子结构和不同的分子量（S110）。 将纺丝溶液电纺并富集以制备纳米纤维（S120）。 基于聚合物的总重量，每种聚合物的重量百分数至少为10％。 多种聚合物是具有不同分子量的聚己内酯物质。

公开(公告)号：KR100791039B1

公开(公告)日：2008-01-03

申请号：KR1020060071624

申请日：2006-07-28

Applicant: 재단법인대구경북과학기술원 ,  영남대학교 산학협력단

Inventor： 이성준 ,  이세근 ,  김호영 ,  김재룡 ,  차영 ,  류원석

IPC: A61L15/12 ,  A61F13/00

CPC classification number: A61L15/12 ,  A61F2013/00089 ,  A61L2300/214 ,  A61L2400/18

Abstract: A nano non-woven fabric containing an antioxidant for wound dressing is provided to improve close adhesion to the skin and air permeability, to prevent contamination by bacterial invasion, and to suppress the production of active oxygen. A nano non-woven fabric for wound dressing contains an antioxidant using a bio-compatible polymer impregnated with N-acetyl-L-cysteine(NAC) as a support. The NAC containing polymer solution having a concentration of 3-20g/dl is then applied to a nano non-woven fabric by electrospinning. Both synthetic polymers or natural polymers can be used as the bio-compatible polymer. Examples of such polymers include polyvinyl alcohol, polyethylene oxide, polyethylene glycol, PLA, PGA, collagen, gelatin, alginate, alginic acid, chitosan, etc.

Abstract translation: 提供含有用于伤口敷料的抗氧化剂的纳米无纺布，以提高对皮肤的密合性和透气性，防止细菌侵入的污染，抑制活性氧的产生。 用于伤口敷料的纳米无纺布包含使用以N-乙酰基-L-半胱氨酸（NAC）作为载体浸渍的生物相容性聚合物的抗氧化剂。 然后通过静电纺丝将具有3-20g / dl浓度的含有NAC的聚合物溶液施加到纳米无纺布上。 合成聚合物或天然聚合物均可用作生物相容性聚合物。 这些聚合物的实例包括聚乙烯醇，聚环氧乙烷，聚乙二醇，PLA，PGA，胶原，明胶，藻酸盐，藻酸，壳聚糖等。