公开(公告)号：KR1020110130274A

公开(公告)日：2011-12-05

申请号：KR1020100049839

申请日：2010-05-27

Applicant: 재단법인대구경북과학기술원

Inventor： 전원배 ,  박보형 ,  박낭운 ,  김인산

IPC: C07K2/00 ,  C12N5/02 ,  A61K47/42 ,  A61K47/40

CPC classification number: C07K2/00 ,  A61K47/42

Abstract: PURPOSE: A multi-block biopolymer is provided to ensure cell recognition functionality and temperature sensitivity. CONSTITUTION: A block biopolymer(100) has m blocks(m is 1-100 integer) which are serially linked. The blocks are one among: peptide I which recognizes cell surface antigen; peptide II with PGX(P is 19 L- or D-amino acids except for L-proline, G is glycine, X is L- or D-proline); peptide III with PGXX; peptide IV with PGXXX; peptide V with PGXGXX; and peptide VI. The peptide I is Arginine-Glycine-Aspartate(RDG) or Arginine-Glycine-Aspartate-Serine(RGDS). The peptide VI which enhances interconnection of the multi-block biopolymers contains PAAAAKAAKZG or PAAAAKAAAKAG.

Abstract translation: 目的：提供多嵌段生物聚合物，以确保细胞识别功能和温度敏感性。 构成：嵌段生物聚合物（100）具有串联连接的m个嵌段（m为1-100个整数）。 块是以下之一：识别细胞表面抗原的肽I; 肽II与PGX（P为19个L-或D-氨基酸，除L-脯氨酸，G为甘氨酸，X为L-或D-脯氨酸）; 具有PGXX的肽III; 具有PGXXX的肽IV; 肽V与PGXGXX; 和肽VI。 肽I是精氨酸 - 甘氨酸 - 天冬氨酸（RDG）或精氨酸 - 甘氨酸 - 天冬氨酸 - 丝氨酸（RGDS）。 增强多嵌段生物聚合物互连的肽VI含有PAAAAKAAKZG或PAAAAKAAAKAG。