公开(公告)号：KR100665976B1

公开(公告)日：2007-01-09

申请号：KR1020060004791

申请日：2006-01-17

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강진모 ,  신동명 ,  김상준 ,  강흔수 ,  하종원

IPC: A01N1/00

CPC classification number: A01N1/0226

Abstract: Compositions for preserving internal organs are provided to interfere RhoA/ROCK cell signal transfer by inhibiting activity of TGase 2(transglutaminase 2), thereby preventing cell damage in the internal organs. The composition for preserving internal organs comprises cystamine, wherein the concentration of cystamine is 50-500 muM; the composition further comprises at least one component selected from osmotic pressure-controlling agent, ATP source, antioxidant and electrolyte ion; the osmotic pressure-controlling agent is hydroxyethyl starch, lactobionate or raffinose; the ATP source is adenosine or alpha-ketoglutarate; the antioxidant is glutathione or allopurinol; the electrolyte ion is sodium, potassium, magnesium or calcium ion; and the osmotic pressure of the composition is 300-350 mOsm/l.

Abstract translation: 提供保存内脏的组合物，通过抑制TGase 2（转谷氨酰胺酶2）的活性来干扰RhoA / ROCK细胞的信号传递，从而防止内脏器官的细胞损伤。 用于保存内脏的组合物包括胱胺，其中胱胺的浓度为50-500μM; 所述组合物还包含选自渗透压控制剂，ATP源，抗氧化剂和电解质离子中的至少一种成分; 渗透压控制剂是羟乙基淀粉，乳糖酸或棉子糖; ATP源是腺苷或α-酮戊二酸; 抗氧化剂是谷胱甘肽或别嘌呤醇; 电解质离子为钠，钾，镁或钙离子; 组合物的渗透压为300-350mOsm / l。