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公开(公告)号：KR1020030070859A
公开(公告)日：2003-09-02
申请号：KR1020030012112
申请日：2003-02-26
Applicant: 재단법인서울대학교산학협력재단
IPC: C01B25/32
CPC classification number: B01J20/048 , C01B25/32
Abstract: PURPOSE: A preparation method of calcium phosphate ion solutions, calcium phosphate colloid ion solutions formed by maintaining the calcium phosphate ion solutions at low temperature, dots or thin films of calcium phosphate formed on a solid substrate using the calcium phosphate colloid ion solutions, and calcium phosphate granules prepared in the calcium phosphate colloid ion solutions are provided. CONSTITUTION: The preparation method of calcium phosphate ion solutions comprises a step (i) of preparing an ion solution having pH of 6.0 to 10.0 including phosphoric acid ions; a step (ii) of preparing an ion solution having pH of 6.0 to 10.0 including calcium ions; and a step (iii) of preparing calcium phosphate solution having pH of 6.0 to 10.0 by mixing the ion solutions. The preparation method of calcium phosphate ion solutions comprises a step (i) of preparing an ion solution having pH of 6.0 or less including phosphoric acid ions and calcium ions; and a step (ii) of preparing calcium phosphate solution having pH of 6.0 to 10.0 by mixing a basic solution with the ion solution. The material including dots is characterized in that it is formed by a method of comprising a step (i) of preparing calcium phosphate ion solution prepared by a preparation method comprising a process (a) of preparing calcium ion and phosphoric acid ion solutions by dissolving calcium salt and phosphoric acid salt into an acidic solution, a process (b) of mixing the prepared calcium ion and phosphoric acid ion solutions with an alkali solution at low temperature, and a process (c) of removing amorphous calcium phosphate granules or crystals from the prepared solution; a step (ii) of preparing calcium phosphate colloid ion solution in the calcium phosphate ion solution by leaving alone the prepared calcium phosphate ion solution at a temperature of 0 to 60 deg.C; and a step (iii) of pouring the prepared calcium phosphate colloid ion solution onto a solid substrate.
Abstract translation: 目的：磷酸钙离子溶液的制备方法，通过使用磷酸钙胶体离子溶液在固体底物上形成的磷酸钙离子溶液在低温下保持形成的磷酸钙胶体离子溶液，磷酸钙的点或薄膜，钙 提供了在磷酸钙胶体离子溶液中制备的磷酸盐颗粒。 构成：磷酸钙离子溶液的制备方法包括：（i）制备pH为6.0〜10.0的离子溶液，包括磷酸离子; 制备pH6.0〜10.0的包含钙离子的离子溶液的工序（ii） 以及通过混合离子溶液制备pH为6.0至10.0的磷酸钙溶液的步骤（iii）。 磷酸钙离子溶液的制备方法包括：（i）制备pH6.0或更低的离子溶液，其包括磷酸离子和钙离子; 以及通过将碱性溶液与离子溶液混合来制备pH为6.0至10.0的磷酸钙溶液的步骤（ii）。 包括点的材料的特征在于其形成方法包括：制备磷酸钙离子溶液的步骤（i）的方法，所述方法包括制备方法，所述制备方法包括通过溶解钙来制备钙离子和磷酸离子溶液的方法（a） 盐和磷酸盐转化成酸性溶液，将制备的钙离子和磷酸离子溶液与低温碱溶液混合的方法（b）和（c）从无机磷酸钙颗粒或晶体中除去 制备溶液; 在磷酸钙离子溶液中通过在0〜60℃的温度下离心制备磷酸钙离子溶液来制备磷酸钙胶体离子溶液的步骤（ii）; 和将所制备的磷酸钙胶体离子溶液倒入固体基质上的步骤（iii）。
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公开(公告)号：KR100511338B1
公开(公告)日：2005-08-31
申请号：KR1020030012112
申请日：2003-02-26
Applicant: 재단법인서울대학교산학협력재단
IPC: C01B25/32
CPC classification number: B01J20/048 , C01B25/32
Abstract: 본 발명은 저온에서 안정화된 인산칼슘 이온 용액을 제조하는방법 및 상기 인산칼슘 이온 용액을 이용하여 제조된 인산칼슘 콜로이드에 관한 것이다. 상기 인산칼슘 콜로이드는 고체기재 상에 부착하여 성장시킴으로써
인산칼슘 반점, 섬 또는 박막 형태를 제조할 수 있고, 용액 내에서 성장시킴으로서 인산칼슘 과립을 제조할 수 있다.-
公开(公告)号：KR1020070067578A
公开(公告)日：2007-06-28
申请号：KR1020050129167
申请日：2005-12-24
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61L27/32 , A61F2250/0025 , A61F2310/00796 , A61L27/02 , A61L27/04 , A61L27/10 , A61L27/3604 , A61L27/3637
Abstract: A biomaterial made of a thin film of calcium phosphate crystals for inhibiting osteoclast differentiation and a manufacturing method thereof are provided to increase biocompatibility by preventing a lower substrate coated with the calcium phosphate thin film of high roughness from being exposed. The method for manufacturing the biomaterial coated with a calcium phosphate thin film of high surface roughness comprises the steps of: pouring calcium phosphate supersaturated solution on the surface of a solid; firstly reacting the calcium phosphate supersaturated solution on the surface of the solid at 20~45°C for 20~40 minutes; pouring the calcium phosphate supersaturated solution on the surface of the calcium phosphate thin film; and secondly reacting the calcium phosphate supersaturated solution on the surface of the calcium phosphate thin film at 20~45°C for 60~120 minutes.
Abstract translation: 提供了由用于抑制破骨细胞分化的磷酸钙晶体薄膜制成的生物材料及其制造方法，通过防止涂覆有高粗糙度的磷酸钙薄膜的下基材露出来提高生物相容性。 用高表面粗糙度的磷酸钙薄膜涂覆生物材料的方法包括以下步骤：将磷酸钙过饱和溶液倒入固体表面; 首先在20〜45℃下将磷酸钙过饱和溶液在固体表面反应20〜40分钟; 将磷酸钙过饱和溶液倒入磷酸钙薄膜表面; 再次将磷酸钙过饱和溶液在20〜45℃磷酸钙薄膜表面反应60〜120分钟。
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公开(公告)号：KR1020030070713A
公开(公告)日：2003-09-02
申请号：KR1020020010227
申请日：2002-02-26
Applicant: 재단법인서울대학교산학협력재단
IPC: A61L27/30
Abstract: PURPOSE: Provided is a method for forming the calcium phosphate crystal thin film on the solid surface wherein the calcium phosphate crystal thin film is formed in a short time, on the hydrophobic surface which is difficult in forming the crystal thin film. CONSTITUTION: The method for forming the calcium phosphate crystal thin film on the solid surface includes coating with the coatings composed of the organic material which is adhered to the solid material and promotes to form a thin film; contacting it with the supersaturated calcium phosphate solution; and cultivating it to form the calcium phosphate crystal thin film. The coatings composed of the organic material has a crystal structure with the hydrophilic and hydrophobic domains together, acts as a linker that is adhered to the solid surface and links the hydrophobic surface with calcium phosphate, promotes to form a thin film, and does not generate an immune reaction in a human body.
Abstract translation: 目的：提供在形成晶体薄膜的疏水性表面上，在短时间内形成磷酸钙晶体薄膜的固体表面上形成磷酸钙晶体薄膜的方法。 构成：在固体表面上形成磷酸钙晶体薄膜的方法包括用附着在固体材料上的有机材料组成的涂层进行涂覆并促进形成薄膜; 使其与过饱和磷酸钙溶液接触; 并培养其形成磷酸钙晶体薄膜。 由有机材料构成的涂层具有一起具有亲水和疏水畴的晶体结构，作为连接器固定在固体表面上并将疏水表面与磷酸钙连接，促进形成薄膜，不产生 人体免疫反应。
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