公开(公告)号：KR100784763B1

公开(公告)日：2007-12-14

申请号：KR1020060120300

申请日：2006-12-01

Applicant: 재단법인서울대학교산학협력재단

Inventor： 조명행 ,  안강호 ,  이진규 ,  권정택 ,  강기태

IPC: G01N33/00 ,  G01N33/497 ,  G01N37/00 ,  G01N35/00

Abstract: A double exposure chamber tool and an apparatus for evaluating the nano-particle inhalation toxicity are provided to evaluate the inhalation toxicity more accurately by preventing an inhaled gas of a tested animal from being flown in, allow mouse to breath smoothly by inhibiting the flow velocity of a tested material through inhalation of the mouse and prevent a tester from being directly exposed to the tested material during the inhalation toxicity test. A double exposure chamber tool(200) comprises an outer chamber member(210) in which a front side portion is opened, a rear side portion is formed to be a closely sealed hollow cylindrical shape, a plurality of outer chamber material outlets is formed at the rear side portion by penetrating therethrough, a plurality of mouse holder binding holes is formed at both sides of a side by penetrating therethrough to be faced to one another and three measuring holes(213) is formed at the upper portion of the side by penetrating therethrough; an outer chamber stopper member(220), one end of which is coupled to the front side portion of the outer chamber member and in which a material inlet is formed at the other end by penetrating therethrough; an inner chamber member which is bound to the inside of the outer chamber member and of which a front side portion is opened, a rear side portion is formed to be closely sealed hollow cylindrical shape, a plurality of inner chamber material outlets is formed at the rear side portion by penetrating therethrough and a plurality of mouse holder binding holes is formed at both sides of a side by penetrating therethrough to be faced to one another; a perforated plate member which is bound to the front side portion of the inner chamber member and is a thin plate shape where a plurality of through holes is formed; and a plurality of mouse holder members(250) which is bound to the mouse holder binding hole of the outer chamber member and in which an animal to be tested for evaluating nano-particle inhalation toxicity is input. An apparatus for evaluating the nano-particles inhalation toxicity of an animal to be tested comprises a multi-layered chamber in which a material inlet and a material outlet are formed at both ends of a parallel space member; and a plurality of double exposure chamber tool.

Abstract translation: 提供双曝光室工具和用于评估纳米颗粒吸入​​毒性的装置，以通过防止被测动物的吸入气体流入而更准确地评估吸入毒性，允许小鼠通过抑制被测动物的流速 通过吸入鼠标测试材料，并防止在吸入毒性试验期间测试仪直接暴露于被测物质。 双曝光室工具（200）包括外侧部件（210），其中前侧部分打开，后侧部分形成为密封的中空圆筒形状，多个外部室材料出口形成在 通过穿过其后侧部分，通过穿过其而彼此相对地在一侧的两侧形成多个鼠标架装订孔，并且在侧面的上部通过穿透形成三个测量孔（213） 其中; 外室止动件（220），其一端连接到外室件的前侧部分，其另一端穿过其中形成材料入口; 内室构件，其结合到外室构件的内部并且其前侧部分打开，后侧部形成为密封的中空圆柱形，多个内室材料出口形成在 通过穿过其后侧部分并且通过穿过其而彼此面对地在一侧的两侧形成多个鼠标架装订孔; 多孔板构件，其与内室构件的前侧部分结合，并且是形成有多个通孔的薄板形状; 和多个与外室构件的鼠标架结合孔结合的鼠标保持构件（250），其中输入用于评价纳米粒子吸入毒性的待测动物。 用于评估被测试动物的纳米颗粒吸入​​毒性的装置包括：多层室，其中在平行空间构件的两端形成材料入口和材料出口; 和多个双曝光室工具。