公开(公告)号：KR1020040020225A

公开(公告)日：2004-03-09

申请号：KR1020020051753

申请日：2002-08-30

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강봉균 ,  김수동

IPC: A61K31/327

Abstract: PURPOSE: A membrane potential changer of an aplysia neuron containing hydrogen peroxide and a cell death-inducing composition of the aplysia neuron containing the membrane potential changer are provided. Use of the composition induces a change in membrane potential and cell death of the aplysia neuron and thus can provide a model useful for the study of memory and learning. CONSTITUTION: The membrane potential changer of an aplysia neuron contains hydrogen peroxide in the range concentration of 0.01 to 10mM. The cell death-inducing composition of the aplysia neuron contains the membrane potential changer of the aplysia neuron. A change in membrane potential is hyperpolarized in the early time after hydrogen peroxide treatment and then depolarized after then. The aplysia is an Aplysia kurodai captured in a costal area of The East Sea of Korea.

Abstract translation: 目的：提供含有过氧化氢的蛋白质神经元的膜电位变化器和含有膜电位变化器的含有神经元的细胞死亡诱导组合物。 组合物的使用会导致膜电位的变化，并且可以提供一种可用于研究记忆和学习的模型。 构成：aplysia神经元的膜电位变化器含有浓度为0.01〜10mM的过氧化氢。 aplysia神经元的细胞死亡诱导组合物含有aplysia神经元的膜电位变化。 膜电位的变化在过氧化氢处理后的早期被超极化，然后在此之后去极化。 大赦国际是在韩国东海沿海地区捕获的阿派利亚kurodai。