公开(公告)号：KR100552401B1

公开(公告)日：2006-02-20

申请号：KR1020030019711

申请日：2003-03-28

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강봉균 ,  김형

IPC: C07K14/47

Abstract: 본 발명은 핵 또는 핵소체(nucleolus)로의 타겟팅에 관여하는 핵 국소화 신호 서열을 포함하는 단백질에 관한 것으로 상기 단백질은 서열번호: 1의 염기서열로 엔코딩되고 상기 국소화 신호 서열은 제85 내지 142번째 및 제355 내지 445번째 염기서열로부터 엔코딩되는 영역에 존재한다.
LAPS18, 핵, 핵소체, 국소화 신호 서열, 핵 국소화 신호 서열

公开(公告)号：KR100782140B1

公开(公告)日：2007-12-06

申请号：KR1020060053476

申请日：2006-06-14

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강봉균 ,  김형

IPC: C12N15/10 ,  C12N15/09 ,  C12N15/63

Abstract: An ApLLP transcription factor derived from Aplysia kurodai is provided to be used as a pharmaceutical composition for improving memory and a screening system for screening an active material useful for the long term memory formation. A primer pair for amplifying a gene of Aplysia kurodai includes sequences described as SEQ ID : NOs. 3 and 4. A method for selecting or searching candidate materials promoting the long term memory formation comprises the steps of: (a) injecting a group of candidate materials effective for the long term memory formation into neurons of Aplysia kurodai and culturing it; and (b) measuring the expression amount of a transcriptional factor described as SEQ ID : NO. 1.

Abstract translation: 提供源自黑腹果蝇的ApLLP转录因子用作改善记忆的药物组合物和筛选用于长期记忆形成的活性物质的筛选系统。 用于扩增黑腹果蝇基因的引物对包括SEQ ID NO：所示的序列。 用于选择或搜索促进长期记忆形成的候选材料的方法包括以下步骤：（a）将有效长期记忆形成的一组候选材料注入到黑腹苷神经元中并进行培养; 和（b）测量如SEQ ID NO：1所述的转录因子的表达量。 1。

公开(公告)号：KR1020040084558A

公开(公告)日：2004-10-06

申请号：KR1020030019711

申请日：2003-03-28

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강봉균 ,  김형

IPC: C07K14/47

CPC classification number: C07K14/43504

Abstract: PURPOSE: A protein having a nucleus localization signal sequence is provided. The protein relates to nucleus or nucleolus targeting. CONSTITUTION: The protein has a nucleus localization signal sequence relating to nucleus or nucleolus targeting of Aplysia kurodai, wherein nucleus or nucleolus is encoded by the nucleotide sequence set forth in SEQ ID NO:1, and is present in the site encoded by the 85th to 142th and 355th to 445th nucleotides. The protein has a nucleus localization signal sequence which relates to nucleus or nucleolus targeting of human, wherein nucleus or nucleolus is encoded by the amino acid sequence set forth in SEQ ID NO:5, and is present in the site encoded by the 103th to 119th amino acids. The protein has a nucleus localization signal sequence relating to nucleus or nucleolus of mouse, wherein nucleus or nucleolus is encoded by the nucleotide sequence set forth in SEQ ID NO:6, and is present in the site encoded by the 47th to 107th and 364th to 413th nucleotides. Primers for producing the nucleus localization signal sequence has the nucleotide sequences of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:12 or SEQ ID NO:14.

Abstract translation: 目的：提供具有核定位信号序列的蛋白质。 该蛋白质涉及核或核仁靶向。 构成：该蛋白质具有涉及黑腹果蝇的核或核仁靶的核定位信号序列，其中核或核仁由SEQ ID NO：1所示的核苷酸序列编码，并且存在于由第85位至 第142和第355至445个核苷酸。 该蛋白质具有涉及人的核或核仁靶向的核定位信号序列，其中核或核仁由SEQ ID NO：5所示的氨基酸序列编码，并存在于第103至第119位编码的位点 氨基酸。 该蛋白质具有与小鼠核或核仁相关的核定位信号序列，其中核或核仁由SEQ ID NO：6所示的核苷酸序列编码，并存在于第47至107和364位编码的位点 第413位核苷酸。 用于产生核定位信号序列的引物具有SEQ ID NO：9，SEQ ID NO：10，SEQ ID NO：12或SEQ ID NO：14的核苷酸序列。