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    참군소에서 분리한 ＡｐＣ/ＥＢＰ 및 ＡｐＣ/ＥＢＰ5'-플랭킹 부위
    1.
    发明公开
    참군소에서 분리한 ＡｐＣ/ＥＢＰ 및 ＡｐＣ/ＥＢＰ5'-플랭킹 부위 失效
    APLYSIA CCAAT增强蛋白（APC / EBP）分离自APLYSIA KURODAI和5-FLANKING REGION

    公开(公告)号：KR1020040019614A

    公开(公告)日：2004-03-06

    申请号：KR1020020051212

    申请日：2002-08-28

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 강봉균 ,  김형규

    IPC: C12N15/12

    CPC classification number: C07K14/43504

    Abstract: PURPOSE: An Aplysia CCAAT enhancer-binding protein(ApC/EBP) isolated from Aplysia kurodai and a 5'-flanking region are provided, thereby increasing expression of ApC/EBP related to long-term memory and consequently improving the long-term memory. CONSTITUTION: A polynucleotide encoding Aplysia CCAAT enhancer-binding protein(ApC/EBP) comprises the nucleotide sequence encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO: 8, wherein the polynucleotide has the nucleotide sequence set forth in SEQ ID NO: 7. A C/EBP(CCAAT-enhancer binding protein long form) polynucleotide comprises the amino acid sequence set forth in SEQ ID NO: 29. A C/EBP(CCAAT-enhancer binding protein short form) polynucleotide comprises the amino acid sequence set forth in SEQ ID NO: 30. A C/EBP 5-flanking region polynucleotide comprises the amino acid sequence set forth in SEQ ID NO: 28. A polynucleotide encoding Aplysia ribosome protein 4(ApS4) comprises the nucleotide sequence encoding a polypeptide having the amino acid sequence set forth in SEQ ID NO: 10, wherein the polynucleotide has the nucleotide sequence set forth in SEQ ID NO: 9. A vector containing the C/EBP 5-flanking region and a foreign gene is provided, wherein the vector expresses the foreign gene when 5-HT is present; the C/EBP 5-flanking region is selected from the nucleotide sequences set forth in SEQ ID NO: 24, SEQ ID NO: 25 and SEQ ID NO: 28; and the foreign gene is selected from GFP gene, luciferase gene and LacZ gene.

    Abstract translation: 目的：提供从阿维链霉菌和5'-侧翼区分离的Aplysia CCAAT增强子结合蛋白（ApC / EBP），从而增加与长期记忆相关的ApC / EBP的表达，从而改善长期记忆。 构成：编码Aplysia CCAAT增强子结合蛋白（ApC / EBP）的多核苷酸包含编码具有SEQ ID NO：8所示氨基酸序列的多肽的核苷酸序列，其中所述多核苷酸具有SEQ ID NO ：AC / EBP（CCAAT-增强子结合蛋白长形式）多核苷酸包含SEQ ID NO：29所示的氨基酸序列.AC / EBP（CCAAT-增强子结合蛋白短型）多核苷酸包含阐述的氨基酸序列 AC / EBP 5-侧翼区多核苷酸包含SEQ ID NO：28所示的氨基酸序列。编码Aplysia核糖体蛋白4（ApS4）的多核苷酸包含编码具有氨基酸的多肽的核苷酸序列 提供了SEQ ID NO：10所示的序列，其中所述多核苷酸具有SEQ ID NO：9所示的核苷酸序列。提供含有C / EBP 5-侧翼区和外源基因的载体，其中载体e 当5-HT存在时，表达外源基因; C / EBP 5-侧翼区选自SEQ ID NO：24，SEQ ID NO：25和SEQ ID NO：28所示的核苷酸序列; 外源基因选自GFP基因，荧光素酶基因和LacZ基因。

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