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公开(公告)号：KR1020090034239A
公开(公告)日：2009-04-07
申请号：KR1020070099510
申请日：2007-10-02
Applicant: 재단법인서울대학교산학협력재단
IPC: C07K19/00
CPC classification number: C07K14/51 , C07K2319/10
Abstract: Cell permeable fusion protein for ossification is provided to prevent and treat diseases like periodontal disease osteoporosis or osteogenesis imperfecta, and osteonosus by transporting protein within cell restricting adipocyte. Cell permeable fusion protein for ossification is formed by performing a covalent bond of amino terminal of a bone tissue and cell-penetrating peptide. The cell-penetrating peptide is oligopeptide containing over 70% of a mixture, low molecular weight protamine, trans activator of transcription, penetratin, polyarginine, polylysine, protamine, protamine, histidine, and arginine.
Abstract translation: 提供用于骨化的细胞可渗透融合蛋白以预防和治疗诸如牙周病骨质疏松症或成骨不全的疾病，以及通过在限制脂肪细胞的细胞内转运蛋白质来治疗骨质疏松症。 用于骨化的细胞可渗透融合蛋白是通过进行骨组织和细胞穿透肽的氨基末端的共价键而形成的。 细胞穿透肽是含有超过70％的混合物，低分子量鱼精蛋白，转录反式激活因子，穿透素，聚精氨酸，聚赖氨酸，鱼精蛋白，鱼精蛋白，组氨酸和精氨酸的寡肽。
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公开(公告)号：KR100951719B1
公开(公告)日：2010-04-07
申请号：KR1020070099511
申请日：2007-10-02
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K49/1866 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/085 , A61K49/14 , B82Y5/00
Abstract: 본 발명은 세포투과성 펩타이드와 형광표지 자성 나노입자의 복합체 및 그 용도에 관한 것으로, 보다 구체적으로, 세포내 투과성 펩타이드와 형광표지 자성나노입자를 화학적으로 결합시킴으로써, 내포작용(endocytosis) 없이, 형광표지 자성나노입자를 세포 내로 안정하게 직접 도입시킬 수 있는 세포투과성 펩타이드-형광표지 자성나노입자 복합체 및 이를 함유하는 세포 영상용 조성물에 관한 것이다.
본 발명에 따르면, 기존의 바이러스성 펩타이드 수송체에서 탈피하여 높은 안정성을 보이고, 최적의 표적 지향화를 통한 영상진단용법의 효과를 극대화하며, 부작용을 최소화하여 혁신적인 치료기술을 제시할 수 있다.
수송도메인, 투과기능성, 펩타이드, 자성나노입자, 세포영상, 조영제-
公开(公告)号：KR1020090034240A
公开(公告)日：2009-04-07
申请号：KR1020070099511
申请日：2007-10-02
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K49/1866 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/085 , A61K49/14 , B82Y5/00
Abstract: A composite of cell-penetrating peptides and magnetic nano particles is provided to secure high stability in comparison with existing viral peptide transporters and maximize effects of video diagnosis by aiming optimal targets. A method for preparing a composite of cell-penetrating peptides and magnetic nano particles comprises the following steps of: preparing a magnetic nano particle containing amino groups by reforming a surface of the magnetic nano particle with amino groups; mixing fluorescent materials to the magnetic nano particle containing amino groups to prepare fluorescent marker magnetic nano particle; and coupling a cell-penetrating peptide with the prepared fluorescent marker magnetic nano particle to produce a composite of cell-penetrating peptides and magnetic nano particles.
Abstract translation: 提供细胞穿透肽和磁性纳米颗粒的复合物，以确保与现有的病毒肽转运蛋白相比具有高度的稳定性，并通过瞄准最佳靶标来最大化视频诊断的效果。 一种制备细胞穿透肽和磁性纳米颗粒复合物的方法包括以下步骤：通过用氨基重整磁性纳米颗粒的表面来制备含有氨基的磁性纳米颗粒; 将荧光材料与含有氨基的磁性纳米颗粒混合，制备荧光标记磁性纳米颗粒; 并将细胞穿透肽与制备的荧光标记物磁纳米颗粒偶联，以产生细胞穿透肽和磁性纳米颗粒的复合物。
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