公开(公告)号：KR100749115B1

公开(公告)日：2007-08-13

申请号：KR1020060027711

申请日：2006-03-28

Applicant: 재단법인서울대학교산학협력재단

Inventor： 허행전 ,  이동은 ,  이기원 ,  이형주

IPC: A61K31/12 ,  A61K31/201 ,  A61P35/00

Abstract: An anticancer composition containing vitamin K3 and conjugated linoleic acid is provided to improve side effect caused by vitamin K3 such as inhibition of intercellular signal transfer through gap junction channel, and increase MMP(matrix metalloproteinase)-inhibiting effects compared to use of single vitamin K3 by using vitamin K3 and conjugated linoleic acid. The anticancer composition contains 0.1-50 wt.% of effective ingredients including vitamin K3 and conjugated linoleic acid in a weight ratio of 10:1 to 1:10, and pharmaceutically acceptable carriers, diluents or excipients, wherein the cancer is large intestine cancer, breast cancer or liver cancer; the daily dosage of effective ingredients is 0.1-100 mg/kg; and the composition is formulated as plaster, granule, lotion, liniment, lemonade, aromatic water, powder, syrup, ophthalmic ointment, liquid and solution, aerosol, extract, elixir, ointment, fluid extract, emulsion, suspension, decoction, infusion, ophthalmic solution, tablet, suppository, injection, spirit, cataplasma, capsule, cream, troche, tincture, paste, pill or soft or hard gelatin capsule.

Abstract translation: 提供含有维生素K3和共轭亚油酸的抗癌组合物以改善由维生素K3引起的副作用，例如通过间隙连接通道抑制细胞间信号转移，并增加MMP（基质金属蛋白酶）抑制作用，与​​使用单一维生素K3相比， 使用维生素K3和共轭亚油酸。 该抗癌组合物含有重量比为10：1至1:10的包括维生素K3和共轭亚油酸在内的有效成分0.1-50重量％，以及药学上可接受的载体，稀释剂或赋形剂，其中癌症为大肠癌， 乳腺癌或肝癌; 有效成分的日剂量为0.1-100mg / kg; 该组合物配制成膏药，颗粒，洗剂，擦剂，柠檬水，芳香水，粉剂，糖浆，眼膏，液体和溶液，气雾剂，提取物，酏剂，软膏，液体提取物，乳剂，混悬剂，煎剂，输液剂，眼科 溶液剂，片剂，栓剂，注射剂，精神剂，泥敷剂，胶囊剂，霜剂，锭剂，酊剂，糊剂，丸剂或软或硬明胶胶囊。