公开(公告)号：KR100809927B1

公开(公告)日：2008-03-06

申请号：KR1020060092901

申请日：2006-09-25

Applicant: 재단법인서울대학교산학협력재단

Inventor： 김상희 ,  이숙진 ,  이태호

IPC: C07C215/10 ,  C07C215/02

CPC classification number: Y02P20/55

Abstract: A method for preparing D-erythro-sphingosine of a natural substance is provided to obtain a sphingosine having trans selectivity and to lower a manufacturing cost by using D-ribo-phytosphingosine. A method for preparing D-erythro-sphingosine comprises the steps of reacting a compound represented by the formula 4 with SOx and oxidizing it, or reacting a compound represented by the formula 4 with SO2X2, thereby preparing a compound represented by the formula 5; cyclic ring opening the compound represented by the formula 5; deprotecting the P2O group of the obtained compound to prepare a compound represented by the formula 3; and deprotecting the compound of the formula 3 to obtain the D-erythro-sphingosine represented by the formula 1, wherein X is a halogen atom; P1 is NH3 or N4; and P2 and P3 are a protecting group.

Abstract translation: 提供了制备天然物质的D-赤式 - 鞘氨醇的方法，以获得具有反式选择性的鞘氨醇，并通过使用D-核糖 - 鞘氨醇作为降低制造成本。 制备D-赤式 - 鞘氨醇的方法包括以下步骤：将式4化合物与SOx反应并使其氧化，或使由式4表示的化合物与SO 2 X 2反应，从而制备由式5表示的化合物; 环式开环由式5表示的化合物; 使所得化合物的P2O基脱保护，制备式3表示的化合物; 并使式3的化合物脱保护，得到式1所示的D-赤式 - 鞘氨醇，其中X为卤素原子; P1是NH3或N4; P2和P3是保护基。