公开(公告)号：KR1020080002341A

公开(公告)日：2008-01-04

申请号：KR1020060061119

申请日：2006-06-30

Applicant: 재단법인서울대학교산학협력재단

Inventor： 신영기 ,  최윤라 ,  박영우 ,  송경 ,  이승현

IPC: A61K38/17 ,  A61K38/00 ,  A61K39/00 ,  G01N33/574

CPC classification number: A61K38/178 ,  A61K38/00 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6849 ,  A61K49/0008 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/732 ,  C07K2317/734 ,  C12N15/1138 ,  C12N2310/14 ,  A61K2300/00

Abstract: A method for inhibiting cancer is provided to inhibit CD24 which is expressed in most of cancers and hinder the binding between CD24 and P-selectin, so that it is useful for treating cancer by inhibiting CD24-overexpressed various cancers. The CD24-overexpressed cancer is inhibited by targeting CD24 through administration of anti-CD24 antibody to a patient, wherein the anti-CD24 antibody is prepared by specifying the amino acid sequence of SEQ ID NO:5 in CD24 sequence of SEQ ID NO:7 as an epitope, wherein the CD24-overexpressed cancers include ovarian cancer, breast cancer, small cell lung cancer, prostate cancer, pancreatic cancer, colon cancer, bladder cancer, liver cancer, small intestine cancer, large intestine cancer, cervical cancer or bile duct cancer.

Abstract translation: 提供了抑制癌症的方法，以抑制在大多数癌症中表达的CD24，并阻碍CD24和P-选择素之间的结合，从而可用于通过抑制CD24-过量表达的各种癌症来治疗癌症。 通过向患者施用抗CD24抗体来靶向CD24来抑制CD24过表达的癌症，其中通过指定SEQ ID NO：7的CD24序列中SEQ ID NO：5的氨基酸序列来制备抗CD24抗体 作为表位，其中CD24-过表达的癌症包括卵巢癌，乳腺癌，小细胞肺癌，前列腺癌，胰腺癌，结肠癌，膀胱癌，肝癌，小肠癌，大肠癌，子宫颈癌或胆管 癌症。