公开(公告)号：KR1020080096091A

公开(公告)日：2008-10-30

申请号：KR1020070041041

申请日：2007-04-27

Applicant: 재단법인서울대학교산학협력재단

Inventor： 이학모 ,  이정렬 ,  이동섭 ,  오병철 ,  이재민

IPC: C12N15/64 ,  C12N15/09 ,  C12N5/00

Abstract: A chemokine receptor 7 is provided to prevent or treat diseases related to immune-adjustment by suppressing or exasperating an immune reaction by adjusting antigen presentation process by an antigen presenting cell by delivering immune controlling factor to a lymph gland and a lymphatic vessel. An expression vector comprises a chemokine receptor 7 gene. The chemokine receptor 7 gene is indicated as a sequence number 1. A cell which is an immunomodulating cell is transformed to the expression vector. The immunomodulating cell is selected from Sertoli cell, mesenchimal stem cell, NK-T cell, ovarian granulosa cell, trophoblast, embryonic stem cell, placenta-derived multipotent stem cell, amniotic epithelial stem cell and cord blood derived stem cell.

Abstract translation: 提供趋化因子受体7以通过将免疫控制因子递送至淋巴管和淋巴管，通过调节抗原呈递细胞的抗原呈递过程来抑制或激怒免疫反应来预防或治疗与免疫调节相关的疾病。 表达载体包含趋化因子受体7基因。 趋化因子受体7基因表示为序列号1.将作为免疫调节细胞的细胞转化为表达载体。 免疫调节细胞选自Sertoli细胞，间充质干细胞，NK-T细胞，卵巢颗粒细胞，滋养层，胚胎干细胞，胎盘衍生的多能干细胞，羊膜上皮干细胞和脐带血干细胞。