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    α-시뉴클레인 검출 및 퇴행성신경질환 진단 조성물 및방법
    5.
    发明公开
    α-시뉴클레인 검출 및 퇴행성신경질환 진단 조성물 및방법 无效
    用于检测α-SYNUCLEIN和用于诊断神经损伤性疾病的组合物和方法

    公开(公告)号：KR1020100015038A

    公开(公告)日：2010-02-12

    申请号：KR1020080075919

    申请日：2008-08-04

    Applicant: 재단법인서울대학교산학협력재단

    Inventor： 백승렬 ,  이정호

    IPC: A61K31/416 ,  A61P25/28

    CPC classification number: A61K31/4184 ,  A61K49/0004

    Abstract: PURPOSE: A composition for detecting alpha-synuclein is provided to selectively detect an amyloid which is derived from the alpha-synuclein and diagnose neurodegenerative diseases including synucleinopathies. CONSTITUTION: A composition for detecting alpha-synuclein contains 5,5'6,6'tetrachloro-1,1,3,3'tetraethylbenzimidazolyl carbocyanine](JC-1) of chemical formula 1 or its salt. The composition is able to detect formation of alpha-synuclein fiber, continuously or in real time. A composition for detecting amyloid which is induced from the alpha-synuclein contains the 5,5'6,6'tetrachloro-1,1,3,3'tetraethylbenzimidazolyl carbocyanine](JC-1) or its salt, and thioflavin-T as active ingredients. A composition for detecting neurodegenerative diseases contains the 5,5'6,6'tetrachloro-1,1,3,3'tetraethylbenzimidazolyl carbocyanine](JC-1) or its salt. The neurodegenerative disease is synucleinopathy including Parkinson's disease, Alzheimer disease, and Lewy body dementia.

    Abstract translation: 目的：提供用于检测α-突触核蛋白的组合物以选择性地检测衍生自α-突触核蛋白的淀粉样蛋白，并诊断神经变性疾病，包括突触核蛋白病。 构成：用于检测α-突触核蛋白的组合物含有化学式1或其盐的5,5'6,6'-四氯-1,1,3,3-四乙基苯并咪唑羰花青（JC-1）。 该组合物能够连续或实时地检测α-突触核蛋白纤维的形成。 用于检测由α-突触核蛋白诱导的淀粉样蛋白的组合物含有5,5'6,6'-四氯-1,1,3,3'-四乙基苯并咪唑羰基碳菁（JC-1）或其盐，硫代黄素-T为 有效成分。 用于检测神经变性疾病的组合物含有5,5'6,6'-四氯-1,1,3,3-四乙基苯并咪唑羰基碳菁（JC-1）或其盐。 神经变性疾病是突触核蛋白病，包括帕金森病，阿尔茨海默病和路易体痴呆。

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