公开(公告)号：KR100953739B1

公开(公告)日：2010-04-19

申请号：KR1020070078301

申请日：2007-08-03

Applicant: 재단법인서울대학교산학협력재단

Inventor： 임창근 ,  박수영

IPC: C12Q1/68 ,  B82Y5/00

Abstract: 본 발명은 피렌의 양쪽에 대칭적으로 올리고데옥시뉴클레오타이드가 도입된 DNA-피렌 복합체를 제공한다. 또한, 상기 복합체를 타겟 올리고데옥시뉴클레오타이드와 하이브리드화하여 만들어진 DNA 나노구조체와 그 제조 방법을 제공한다.
피렌, 올리고데옥시뉴클레오타이드, 엑시머, 하이브리드

公开(公告)号：KR1020090014062A

公开(公告)日：2009-02-06

申请号：KR1020070078301

申请日：2007-08-03

Applicant: 재단법인서울대학교산학협력재단

Inventor： 임창근 ,  박수영

IPC: C12Q1/68 ,  B82Y5/00

CPC classification number: C12Q1/6876 ,  B82Y5/00 ,  C12Q2563/107

Abstract: A DNA-pyrene complex is provided to improve the detection ability based on the fluorescence alteration through the new protocol for making the fluorescent DNA nanostructure, and supply the research basis on the DNA sensor, biocompatible fluorescence probe or label and opticoelectronic material by using the new DNA-pyrene composite. The DNA-pyrene composite has the structure of the oligodeoxynucleotide-pyrene-oligodeoxynucleotide(OPO), wherein the oligodeoxynucleotide has the nucleotide sequence complementary with the 5' to 3' DNA half fragment or 3' to 5' DNA half fragment of target oligodeoxynucleotide. The fluorescent DNA nanostructure is produced by hybridizing the DNA-pyrene composite with the corresponding target oligodeoxynucleotide, and has the core-shell structure including the pyrene core and DNA surrounding the core.

Abstract translation: 提供了一种DNA芘复合物，通过新的荧光DNA纳米结构方案，通过荧光改变提高检测能力，并通过使用新型的DNA传感器，生物相容性荧光探针或标签和光电材料提供研究依据 DNA芘复合物。 DNA-芘复合物具有寡脱氧核苷酸 - 芘 - 寡脱氧核苷酸（OPO）的结构，其中寡脱氧核苷酸具有与靶寡脱氧核苷酸的5'至3'DNA半片段或3'至5'DNA半片段互补的核苷酸序列。 荧光DNA纳米结构是通过将DNA-芘复合物与相应的靶寡脱氧核苷酸杂交产生的，其核 - 壳结构包括芘核和围绕核的DNA。