노화에 관여하는 신호 및 분자종
    2.
    发明授权
    노화에 관여하는 신호 및 분자종 失效
    信号和分子参与感知

    公开(公告)号:KR100734429B1

    公开(公告)日:2007-07-03

    申请号:KR1020047019858

    申请日:2002-06-05

    Abstract: 본 발명은 (a) 신호 전달에 관여하는 시그널 또는 분자종의 어린 세포에 대한 상대적인 변화를 측정하는 단계를 포함하는 노화 세포의 검출방법; 그리고 (b) 아데닐일 시클라아제의 억제제 또는 단백질 키나아제 A의 억제제의 유효량을 노화 세포에 처리하는 단계를 포함하는 세포 노화 조절 방법 및 (c) 조성물에 관한 것이다.

    노화에 관여하는 신호 및 분자종
    4.
    发明公开
    노화에 관여하는 신호 및 분자종 失效
    检测敏感细胞,识别细胞感染的鉴别物质和调节细胞感受参与的信号和分子物种

    公开(公告)号:KR1020050023292A

    公开(公告)日:2005-03-09

    申请号:KR1020047019858

    申请日:2002-06-05

    Abstract: PURPOSE: Signals and molecular species involved in senescence are provided, thereby easily detecting a senescent cell, identifying a substance affecting the cell senescence, and regulating the cell senescence. CONSTITUTION: A method for detecting a senescent cell comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction, wherein the alteration in the signal or molecular species is one or more selected from (a) reduction in Ca2+ oscillation, (b) reduction in expression of F-actin, (c) reduction in activity of phospholipase C, (d) reduction in activity of phospholipase D, (e) reduction in expression or phosphorylation of platelet-derived growth factor receptor, (f) reduction in phosphorylation of phospholipase C-γ1, (g) reduction in expression of phospholipase D1, (h) reduction in expression of EDG-2, (i) reduction in expression of EDG-7, (j) reduction in expression of Gil, (k) reduction in expression of Gi2, (1) reduction in expression of Gi3, (m) increase in activity or expression of adenylyl cyclase, (n) reduction in activity or expression of phophodiesterase, (o) increase in activity of protein kinase C, (p) increase in activity or expression of protein kinase A, (q) increase in phosphorylation of CREB, and (r) increase in cAMP content; the signals or molecular species of (a) to (g) are involved in the signal transduction triggered by a platelet-derived growth factor; and the signals or molecular species of (h) to (r) are involved in the signal transduction triggered by lysophosphatidic acid.

    Abstract translation: 目的:提供参与衰老的信号和分子物质,从而容易地检测衰老细胞,鉴定影响细胞衰老的物质和调节细胞衰老。 构成:用于检测衰老细胞的方法包括测量参与信号转导的信号或分子物种中的年轻细胞的相对变化,其中信号或分子种类的改变是选自(a)Ca2 +振荡降低中的一种或多种 ,(b)F-肌动蛋白的表达降低,(c)磷脂酶C的活性降低,(d)磷脂酶D的活性降低,(e)血小板衍生生长因子受体的表达或磷酸化的降低,(f )减少磷脂酶C-γ1的磷酸化,(g)磷脂酶D1表达的降低,(h)EDG-2表达的降低,(i)EDG-7的表达降低,(j)Gil表达的降低 ,(k)Gi2的表达减少,(1)Gi3表达的降低,(m)腺苷酸环化酶的活性或表达增加,(n)phophodiesterase的活性或表达的降低,(o)蛋白质的活性增加 激酶C,(p)活性增加 或q蛋白激酶A的表达,(q)CREB磷酸化增加,(r)cAMP含量增加; (a)至(g)的信号或分子物质参与由血小板衍生生长因子触发的信号转导; (h)至(r)的信号或分子物质参与由溶血磷脂酸引发的信号转导。

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