公开(公告)号：KR100799246B1

公开(公告)日：2008-01-29

申请号：KR1020060127039

申请日：2006-12-13

Applicant: 재단법인서울대학교산학협력재단

Inventor： 박승범 ,  장환종 ,  고성곤 ,  김은하

IPC: C07D491/048 ,  C07D491/147

CPC classification number: C07D491/052 ,  C07D311/04 ,  C07D491/107 ,  C07D491/147 ,  C07D491/20

Abstract: Compounds with an embedded benzopyran motif as core structures are provided to inhibit growth of cancer cells, so that they are useful for treatment of cancer. A preparation method of the compounds is also provided to improve convenience of preparation by using aqueous phase synthesis and solid phase synthesis. Compounds with an embedded benzopyran motif as core structures, represented by the formula(1) to formula(10) are provided, wherein Y and Z are each independently hydrogen; C1-C6 linear or branched alkyl; hydroxy; protected hydroxy as a C3-C9 linear or branched alkylsilyl ether type; halogen; C1-C6 linear or branched alkoxy; or phenyl optionally substituted by at least one selected from C1-C6 linear or branched alkyl, C1-C6 linear or branched alkoxy, hydroxy, hydroxy protected as a C3-C9 linear or branched alkylsilyl ether type, halogen, amino, C1-C4 alkylamino, C1-C4 dialkylamino, acetyl or benzoyl; R1 is hydrogen; methoxymethyl; C1-C6 linear or branched alkyl; benzyl; C1-C6 linear or branched alkoxy; or phenyl optionally substituted by at least one selected from C1-C6 linear or branched alkyl, C1-C6 linear or branched alkoxy, hydroxy, halogen, amino, C1-C4 alkylamino, C1-C4 dialkylamino, acetyl or benzoyl; and R is methyl or -CH2(CH2)2CH2-.

Abstract translation: 提供具有嵌入的苯并吡喃基序作为核心结构的化合物以抑制癌细胞的生长，使得它们可用于治疗癌症。 还提供了该化合物的制备方法，以通过使用水相合成和固相合成来提高制备的便利性。 提供了由式（1）至式（10）表示的具有嵌入的苯并吡喃基序作为核心结构的化合物，其中Y和Z各自独立地为氢; C1-C6直链或支链烷基; 羟基; 保护的羟基为C 3 -C 9直链或支链烷基甲硅烷基醚型; 卤素; C1-C6直链或支链烷氧基; 或任选被至少一个选自C 1 -C 6直链或支链烷基，C 1 -C 6直链或支链烷氧基，羟基，C 3 -C 9直链或支链烷基甲硅烷基醚保护的羟基取代的苯基，卤素，氨基，C 1 -C 4烷基氨基 ，C 1 -C 4二烷基氨基，乙酰基或苯甲酰基; R1是氢; 甲氧基甲基; C1-C6直链或支链烷基; 苄基; C1-C6直链或支链烷氧基; 或任选被至少一个选自C 1 -C 6直链或支链烷基，C 1 -C 6直链或支链烷氧基，羟基，卤素，氨基，C 1 -C 4烷基氨基，C 1 -C 4二烷基氨基，乙酰基或苯甲酰基取代的苯基; 且R为甲基或-CH 2（CH 2）2 CH 2 - 。