公开(公告)号：KR100552402B1

公开(公告)日：2006-02-20

申请号：KR1020030019712

申请日：2003-03-28

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강봉균 ,  허민정

IPC: C07K14/47

Abstract: 본 발명은 시냅스 가소성(synaptic plasticity) 및 유전자 전달(gene transfer) 연구에 유용한 새로운 기능을 가지는 단백질에 관한 것으로 상기 단백질은 GEF(GDP/GTP exchange 팩터) 활성 의존적인 방법으로 신경돌기 생성과 시냅스 전달을 조절하며, 세포골격 조절을 통하여 신경돌기 생성을 유발하고, GEF 활성 의존적인 방법으로 정맥류(varicosity)를 증가시킨다.
msec7-1, GDP/GTP Exchange 팩터, ADP 리보실레이션 팩터, 신경돌기 생성, 감각-운동 공배양, 시냅스 전달

公开(公告)号：KR1020040084559A

公开(公告)日：2004-10-06

申请号：KR1020030019712

申请日：2003-03-28

Applicant: 재단법인서울대학교산학협력재단

Inventor： 강봉균 ,  허민정

IPC: C07K14/47

CPC classification number: C07K14/4705

Abstract: PURPOSE: Protein msec7 with novel function is provided, which regulates neuritogenesis and synaptic transmission in neuron of Aplysia kurodai, and relates to membrane traffic of the neuron cell and modulation of actin cytoskeleton. Therefore, the protein msec7 is useful in the study on synaptic plasticity and gene transfer. CONSTITUTION: The protein msec7 regulates neuritogenesis and synaptic transmission by GEF(GDP/GTP exchange factor) activity dependent method, wherein the protein msec7 induces neuritogenesis by modulation of actin cytoskeleton; the protein msec7 increases varicosity by GEF(GDP/GTP exchange factor) activity dependent method; the protein msec7 comprises msec7-1 and msec7-2; and the protein msec7-1 is encoded by the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO2, and the protein msec7-2 is encoded by the nucleotide sequence of SEQ ID NO:3.

Abstract translation: 目的：提供具有新功能的蛋白质msec7，其调节神经细胞神经元的神经发生和突触传递，涉及神经元细胞的膜交换和肌动蛋白细胞骨架的调节。 因此，蛋白质msec7在突触可塑性和基因转移研究中是有用的。 构成：蛋白质msec7通过GEF（GDP / GTP交换因子）活性依赖性方法调节神经发生和突触传递，其中蛋白质msec7通过调节肌动蛋白细胞骨架诱导神经发生; 蛋白质msec7通过GEF（GDP / GTP交换因子）活性依赖性方法增加静脉曲张; 蛋白质msec7包括msec7-1和msec7-2; 并且蛋白质msec7-1由SEQ ID NO：1或SEQ ID NO 2的核苷酸序列编码，并且蛋白质msec7-2由SEQ ID NO：3的核苷酸序列编码。