公开(公告)号：KR1020020092160A

公开(公告)日：2002-12-11

申请号：KR1020020002032

申请日：2002-01-14

Applicant: 재단법인서울대학교산학협력재단 ,  주식회사 팜트리

Inventor： 서영거 ,  신동윤 ,  박선현 ,  이도상

IPC: C07D311/78

Abstract: PURPOSE: Provided are novel ortho-naphthopyranoquinone derivatives which are excellent in antimicrobial and antifungal activities with less toxicity, and a pharmaceutical composition including an antimicrobial agent and an antifungal agent, using the same. CONSTITUTION: The novel ortho-naphthopyranoquinone derivative is represented by the formula(1), wherein A is as represented in the description; B is O or C; R1 is hydrogen, a C1-C4 alkyl group, an acetyl group, -C(=O)R5, or -C(=O)OR6, wherein R5 and R6 are a C1-C4 alkyl group; R2 is hydrogen, a C1-C6 linear or branched alkyl group; C1-C4 alkoxy group, -C(=O)OR7, wherein R7 is a C1-C4 alkyl group or -CN; R3 and R4 are the same or different each other, and individually represent hydrogen, halogen atom, a halogen atom substituted or unsubstituted C1-C6 linear or branched alkyl group, -C(=O)R8; -CH2C(=O)R9, wherein R8 and R9 are hydrogen or a C1-C4 alkyl group; and R3 and R4 bind together to form 5 or 6 membered hetero cycle, wherein the hetero cycle is selected from N, S or O.

Abstract translation: 目的：提供具有较低毒性的抗微生物和抗真菌活性优异的新型邻萘并芴醌衍生物，以及包含抗微生物剂和抗真菌剂的药物组合物。 构成：新型邻 - 萘并ran醌衍生物由式（1）表示，其中A如说明书所示; B是O或C; R1是氢，C1-C4烷基，乙酰基，-C（= O）R5或-C（= O）OR6，其中R5和R6是C1-C4烷基; R2是氢，C1-C6直链或支链烷基; C 1 -C 4烷氧基，-C（= O）OR 7，其中R 7是C 1 -C 4烷基或-CN; R 3和R 4彼此相同或不同，并分别表示氢，卤素原子，卤素原子取代或未取代的C 1 -C 6直链或支链烷基，-C（= O）R 8; -CH 2 C（= O）R 9，其中R 8和R 9是氢或C 1 -C 4烷基; 并且R3和R4结合在一起形成5或6元杂环，其中杂环选自N，S或O.

公开(公告)号：KR100521841B1

公开(公告)日：2005-10-17

申请号：KR1020020002032

申请日：2002-01-14

Applicant: 재단법인서울대학교산학협력재단 ,  주식회사 팜트리

Inventor： 서영거 ,  신동윤 ,  박선현 ,  이도상

IPC: C07D311/78

Abstract: 본 발명은 하기 화학식 1로 표시되는 오르토-나프토피라노퀴논 유도체, 제조방법 및 이를 포함하는 약학적 조성물에 관한 것으로, 상기 화합물은 항균 및 항진균 효과가 우수하고 독성이 적어 항균제 및 항진균제로 유용하게 사용될 수 있다.
화학식 1

(상기 식에서, A, B, R
1 및 R
2 는 명세서 내에서 정의한 바와 같다)